Incomplete Kawasaki Disease as Presentation of COVID-19 Infection in an Infant: A Case Report

Journal of Tropical Pediatrics - Tập 67 Số 3 - 2021
Sumantra Raut1, Satyabrata Roychowdhoury1, Subhajit Bhakta1, Mihir Sarkar1, Madhumita Nandi1
1Department of Pediatrics, Medical College, Kolkata, West Bengal 700073, India

Tóm tắt

ABSTRACT Background Recently a severe form of COVID-19 infection has been described in a cluster of children presenting as multisystem inflammatory condition. One of the important spectrum of this condition is incomplete Kawasaki disease (KD). Case report A 5-month-old male child presented with high-spiking fever for 5 days with skin rash, bilateral non-purulent conjunctivitis and irritability. His C-reactive protein was markedly elevated (215.4 mg/l). Echocardiography revealed dilated left main coronary artery (3.0 mm, Z score +4.30) and left anterior descending artery (2.37 mm, Z score +3.76). Concomitantly Reverse Transcription- Polymerase Chain Reaction for COVID-19 was positive on fifth day sample. He was diagnosed as incomplete KD with COVID-19 infection and treated with intravenous immunoglobulin (IVIG) (2 g/kg), oral aspirin and azithromycin. Patient improved after 48 h and was discharged on oral aspirin. Conclusion Incomplete KD may co-exist with COVID-19 infection in infant. Early institution of IVIG may lead to better outcome.

Từ khóa


Tài liệu tham khảo

Hang, 2006, Characteristics of Kawasaki disease in infants younger than six months of age, Pediatr Infect Dis J, 25, 241, 10.1097/01.inf.0000202067.50975.90

2020, Coronavirus Disease 2019 in children—United States, February 12–April 2, 2020, MMWR Morb Mortal Wkly Rep, 69, 422, 10.15585/mmwr.mm6914e4

Docherty, 2020, 10.1101/2020.04.23.20076042 (preprint)

Verdoni, 2020, An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study, Lancet, 395, 1771, 10.1016/S0140-6736(20)31103-X

Toubiana

Jones, 2020, COVID-19 and Kawasaki Disease: Novel Virus and Novel Case, Hospital Pediatrics, 10, 537, 10.1542/hpeds.2020-0123

McCrindle, 2017, Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association, Circulation, 135, e927, 10.1161/CIR.0000000000000484

Minich, 2007, Pediatric Heart Network Investigators. Delayed diagnosis of Kawasaki disease: what are the risk factors?, Pediatrics, 120, e1434, 10.1542/peds.2007-0815

Riphagen, 2020, Hyperinflammatory shock in children during COVID-19 pandemic, Lancet (London, England), 395, 1607, 10.1016/S0140-6736(20)31094-1

2020

Thông tin
Thông tin xuất bản

Journal of Tropical Pediatrics

Tập 67 Số 3

Thông tin tác giả