Incidence and relative survival of chordomas

Cancer - Tập 119 Số 11 - Trang 2029-2037 - 2013
Nicolas R. Smoll1, Oliver Gautschi1, Ivan Radovanovic1, Karl Schaller1, Damien C. Weber2
1Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland
2Departement of Radiation Oncology Geneva University Hospital Geneva Switzerland

Tóm tắt

BACKGROUND

Chordomas are rare bone tumors arising from remnants of the embryonic notochord.

METHODS

Data for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (1973‐2009) to calculate the incidence, relative survival (RS), and standardized mortality ratio (SMR) of patients diagnosed with intracranial and extracranial chordomas and to assess the effects of age and sex on this disease.

RESULTS

The overall incidence of extracranial and intracranial chordomas was 8.4 per 10 million population. The median overall survival of patients with chordoma patients was 7.7 years. The median survival was 7.7 years for male patients and 7.8 years for female patients. Younger patients (aged <40 years) survived longer compared with older patients (10‐year RS, 68% vs 43%). The estimated age‐standardized 5‐year, 10‐year, and 20‐year RS rates was 72%, 48%, and 31%, respectively. The SMR in the overall cohort was 4.6 (95% confidence interval, 4.22‐5.0) or 21.0 (95% confidence interval, 16.6‐27.2) in young adult patients and 3.0 (95% confidence interval, 2.6‐3.4) in elderly patients.

CONCLUSIONS

The elderly had a more aggressive form of this disease; and, other than the incidence, sex did not influence outcome in this disease. The study of chordomas presents a good case for the contribution that the SMR can have on measuring the impact of a disease on a population of patients. Although the younger population has better survival rates, the impact (SMR) in the younger age groups is much higher than in older populations. Cancer 2013;119:2029–2037. © 2013 American Cancer Society.

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Tài liệu tham khảo

10.1002/path.1711710404

10.1023/A:1008947301735

10.1002/(SICI)1096-8628(19980123)75:3<335::AID-AJMG23>3.0.CO;2-P

10.1002/(SICI)1097-0215(19990331)81:1<24::AID-IJC5>3.0.CO;2-O

10.1086/321982

10.1302/0301-620X.88B5.17299

10.1038/ng.454

10.1007/s004310000645

10.1002/gcc.20052

10.3171/foc.2001.10.3.3

10.1007/s007010170013

10.3340/jkns.2009.45.4.243

10.1007/s00586-007-0468-x

10.2214/ajr.108.2.333

10.1016/j.ijrobp.2005.02.023

10.1007/s00066-003-1065-5

10.1007/s00066-003-1120-2

10.1016/S1042-3680(18)30088-3

10.1016/0360-3016(94)90550-9

10.1007/BF03038890

10.3171/jns.1989.70.1.0013

10.1002/1097-0142(19941015)74:8<2261::AID-CNCR2820740809>3.0.CO;2-0

10.1227/00006123-199505000-00001

10.1016/j.ijrobp.2006.08.052

10.3171/jns.1999.91.3.0432

10.1016/0360-3016(88)90295-7

10.1016/S0360-3016(97)00041-2

10.1016/0360-3016(95)02014-3

World Health Organization, 2011, International Classification of Diseases for Oncology

10.1002/1097-0142(19951201)76:11<2343::AID-CNCR2820761124>3.0.CO;2-#

AlbrittonK AndersonB NicholsC UlmanD. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer. Report of the Adolescent and Young Adult Oncology Progress Review Group. National Cancer Institute/Lance Armstrong Foundation;2006. Available at:www.cancer.gov/cancertopics/aya/reports. [Accessed February 28 2013]

National Cancer Institute; Surveillance, Epidemiology, and End Results (SEER) Program, 2011, SEER 17 Regs Research Data 1973‐2007

National Cancer Institute; Surveillance, Epidemiology, and End Results (SEER) Program, 2012, SEER*Stat Database: Mortality—All COD, Aggregated with state, Total US (1969‐2007), Katrina/Rita Population Adjustment

10.1016/j.ejca.2011.03.011

10.1002/sim.1597

10.1097/EDE.0b013e3181c1ea43

10.1002/cncr.26387

10.1093/neuonc/nos144

Price R, 1773, Observations on Reversionary Payments; on Schemes for Providing Annuities for Widows, and for Persons in Old Age; on the Method of Calculating the Values of Assurances on Lives; and on the National Debt: to Which Are Added, Four Essays on Different Subjects in the Doctrine of Life‐Annuities and Political Arithmetick

Breslow NE, 1987, Statistical methods in cancer research. Volume II—The design and analysis of cohort studies, IARC Sci Publ., 82, 1

Smoll NR, 2013, Long‐term survivors of glioblastoma multiforme (GBM) [published online ahead of print January 23, 2013], J Clin Neurosci.

Addison J, 1910, English Essays: From Sir Philip Sidney to Macaulay, 77

10.1111/j.1467-985X.2010.00640.x

10.1007/s10143-011-0334-5

10.1016/S0360-3016(01)02827-9

10.1016/S0360-3016(01)01634-0

10.1016/j.ijrobp.2004.05.064

10.1097/BRS.0b013e3181b44387

10.1016/S0895-4356(97)00099-1