Incidence and 10-Year Survival of Intracerebral Hemorrhage in a Population-Based Registry

Stroke - Tập 40 Số 2 - Trang 394-399 - 2009
Simona Sacco1, Carmine Marini1, Danilo Toni1, Luigi Olivieri1, Antonio Carolei1,2
1From the Department of Neurology (S.S., C.M., L.O., A.C.), University of L'Aquila, L'Aquila, Italy; and the Department of Neurological Sciences (D.T.), Università La Sapienza, Rome, Italy.
2Universita' La Sapienza, Rome, Italy

Tóm tắt

Background and Purpose— The purpose of this study was to evaluate the incidence and prognosis of intracerebral hemorrhage. Methods— We analyzed data referring to our prospective population-based registry, including patients with a first-ever stroke followed up to 10 years. Results— In a 5-year period, we included 549 patients (247 men and 302 women; mean age±SD, 73.6±12.5 years) with an intracerebral hemorrhage. The crude annual incidence rate was 36.9 per 100000 (95% CI, 33.8 to 40.0), 32.9 per 100000 when standardized to the 2006 European population, and 15.9 per 100000 when standardized to the world population. The case-fatality rate was 34.6% (95% CI, 30.6 to 38.6) at 7 days; it increased to 50.3% (95% CI, 46.1 to 54.5) at 30 days and to 59.0% (95% CI, 54.9 to 63.1) at 1 year. Diabetes mellitus and posterior fossa hemorrhage were associated with an increased risk of 7- and 30-day mortality, whereas older age was associated with an increased risk of 30-day mortality only. At the Kaplan-Meier analysis, the 10-year survival rate was 24.1% (95% CI, 20.1 to 28.1). Conclusions— Intracerebral hemorrhage is characterized by a severe prognosis, mostly in the short term. Because of the high proportion of fatal events that occurs early after the stroke, it is mandatory to identify and apply specific therapeutic strategies for patients with intracerebral hemorrhage.

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Tài liệu tham khảo

10.1016/S1474-4422(03)00266-7

10.1161/str.28.12.2500

10.1159/000054766

10.1161/01.STR.0000199147.30016.74

Stroke Prevention and Educational Awareness Diffusion. Italian Guidelines for Stroke Prevention and Management: Syntheses and Recommendations. Milan Italy: Stroke Prevention and Educational Awareness Diffusion; 2007.

10.1161/01.str.0000082382.42061.ee

10.1161/str.28.3.491

Istituto Centrale di Statistica. Popolazione e abitazioni. 13° Censimento generale della popolazione e delle abitazioni 20 ottobre 1991 Fascicolo provinciale 66 L'Aquila Roma 1993:1–300.

ISTAT. 14° censimento generale della popolazione e delle abitazioni 21 ottobre 2001. Available at: http://dawinci.istat.it/daWinci/jsp/MD/misc.jsp?p=2. Accessed September 1 2007.

World Health Organization. Manual of the International Statistical Classification of Diseases Injuries and Causes of Death 9th Revision Vol 1. Geneva: World Health Organization; 1977.

10.1212/WNL.28.8.754

10.1161/str.17.2.3961838

World Health Organization. Application of the International Classification of Diseases to Neurology (ICD-10 NA). II ed. Geneva: World Health Organization; 1997.

EUROSTAT. Population and social conditions. Available at: http://epp.eurostat.ec.europa.eu/portal/page?_pageid=0 1136184 0_45572595&_dad=portal&_schema=PORTAL. Accessed September 1 2007.

Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat World Population Prospects: The 2006 Revision and World Urbanization Prospects: The 2005 Revision. Available at: http://esa.un.org/unpp. Accessed May 28 2008.

10.1136/jnnp.54.7.595

10.1161/01.str.0000221714.96986.5f

10.1016/S0140-6736(05)67702-1

10.1161/str.32.8.1732

10.1136/jnnp.57.8.936

10.1136/jnnp.53.1.16

10.1161/str.29.12.2501

10.1212/01.wnl.0000172915.71933.00

10.1016/S1474-4422(05)70325-2

10.1136/jnnp.2006.089292

10.1159/000107814

10.1159/000008177

10.1161/hyp.31.6.1223

10.1056/NEJM198904063201405

10.1016/S0140-6736(00)04213-6

10.1056/NEJMoa061894

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Stroke

Tập 40 Số 2

394-399

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