Inappropriate sexual behaviors in cognitively impaired older individuals

Lyketsos, 2000, Mental and behavioral disturbances in dementia: Findings from the Cache County Study on Memory in Aging, Am J Psychiatry, 157, 708, 10.1176/appi.ajp.157.5.708 Margallo-Lana, 2001, Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments, Int J Geriatr Psychiatry, 16, 39, 10.1002/1099-1166(200101)16:1<39::AID-GPS269>3.0.CO;2-F Finkel, 1996, Behavioral and psychological signs and symptoms of dementia: A consensus statement on current knowledge and implications for research and treatment, Int Psychogeriatr, 8, 497 Steele, 1990, Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease, Am J Psychiatry, 147, 1049, 10.1176/ajp.147.8.1049 O'Donnell, 1992, Incontinence and troublesome behaviors predict institutionalization in dementia, J Geriatr Psychiatry Neurol, 5, 45, 10.1177/002383099200500108 Marsiglio, 1991, Sexual relations in later life: A national study of married persons, J Gerontol, 46, S338, 10.1093/geronj/46.6.S338 Comfort, 1991, Sexuality and aging: An overview, Clin Geriatr Med, 7, 1, 10.1016/S0749-0690(18)30561-5 Johnson, 2006, Challenges associated with the definition and assessment of inappropriate sexual behaviour amongst individuals with an acquired neurological impairment, Brain Inj, 20, 687, 10.1080/02699050600744137 Kuhn, 1998, Addressing hypersexuality in Alzheimer's disease, J Gerontol Nurs, 24, 44, 10.3928/0098-9134-19980401-11 Higgins, 2004, Hypersexuality and dementia: Dealing with inappropriate sexual expression, Br J Nurs, 13, 1330, 10.12968/bjon.2004.13.22.17271 Wright, 1993 Derouesné, 1996, Sexual behavioral changes in Alzheimer disease, Alzheimer Dis Assoc Disord, 10, 86, 10.1097/00002093-199601020-00006 Tsai, 1999, Inappropriate sexual behaviors in dementia: A preliminary report, Alzheimer Dis Assoc Disord, 13, 60, 10.1097/00002093-199903000-00009 Alagiakrishnan, 2005, Sexually inappropriate behaviour in demented elderly people, Postgrad Med J, 81, 463, 10.1136/pgmj.2004.028043 Zeiss, 1996, An observational study of sexual behavior in demented male patients, J Gerontol A Biol Sci Med Sci, 51, M325, 10.1093/gerona/51A.6.M325 Lesser, 2005, Sexually inappropriate behaviors. Assessment necessitates careful medical and psychological evaluation and sensitivity, Geriatrics, 60, 34 Sloane, 1993, Sexual behavior in residents with dementia. Guidelines explain how to respond, Contemp Longterm Care, 16, 66 Arnulf, 2005, Kleine-Levin syndrome: A systematic review of 186 cases in the literature, Brain, 128, 2763, 10.1093/brain/awh620 Goscínski, 1997, The Kluver-Bucy syndrome, Acta Neurochir (Wien), 139, 303, 10.1007/BF01808825 Goscínski, 1997, The Kluver-Bucy syndrome, J Neurosurg Sci, 41, 269 Cummings, 1995, Behavioral and psychiatric symptoms associated with Huntington's disease, Adv Neurol, 65, 179 Miller, 1986, Hypersexuality or altered sexual preference following brain injury, J Neurol Neurosurg Psychiatry, 49, 867, 10.1136/jnnp.49.8.867 Klos, 2005, Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy, Parkinsonism Relat Disord, 11, 381, 10.1016/j.parkreldis.2005.06.005 Uitti, 1989, Hypersexuality with antiparkinsonian therapy, Clin Neuropharmacol, 12, 375, 10.1097/00002826-198910000-00002 Markham, 1974, Parkinson's disease and levodopa. A five-year follow-up and review, West J Med, 121, 188 Cannas, 2006, Hypersexual behaviour, frotteurism, and delusional jealousy in a young parkinsonian patient during dopaminergic therapy with pergolide: A rare case of iatrogenic paraphilia, Prog Neuropsychopharmacol Biol Psychiatry, 30, 1539, 10.1016/j.pnpbp.2006.05.012 Lam, 2007, Sexual disinhibition in schizophrenia possibly induced by risperidone and quetiapine, Psychiatry Clin Neurosci, 61, 333, 10.1111/j.1440-1819.2007.01667.x Nickel, 2007, Cabergoline treatment in men with psychogenic erectile dysfunction: A randomized, double-blind, placebo-controlled study, Int J Impot Res, 19, 104, 10.1038/sj.ijir.3901483 Wittstock, 2002, Cabergoline can increase penile erections and libido, Neurology, 58, 831, 10.1212/WNL.58.5.831 Fernandez, 1998, Clozapine for dopaminergicinduced paraphilias in Parkinson's disease, Mov Disord, 13, 597, 10.1002/mds.870130338 Schober, 2007, The neurophysiology of sexual arousal, Best Prac Res Clin Endocrinol Metab, 21, 445, 10.1016/j.beem.2007.04.006 Kafka, 2003, The monoamine hypothesis for the pathophysiology of paraphilic disorders: An update, Ann NY Acad Sci, 989, 86, 10.1111/j.1749-6632.2003.tb07295.x Saleh, 2003, Sex hormones, neurotransmitters, and psychopharmacological treatments in men with paraphilic disorders, J Child Sex Abus, 12, 233, 10.1300/J070v12n03_09 Loosen, 1994, Effects on behavior of modulation of gonadal function in men with gonadotropin-releasing hormone antagonists, Am J Psychiatry, 151, 271, 10.1176/ajp.151.2.271 Guay DR. Drug treatment of paraphilias. Clin Ther. In press. Neumann, 1975, Discovery, development, mode of action, and clinical use of cyproterone acetate, J Int Med Res, 3, 1 Stitch, 1975, Steroid chemistry, J Int Med Res, 3, 10 Neumann, 1970, Aspects of androgen-dependent events as studied by antiandrogens, Rec Prog Hormone Res, 26, 337 Bohl, 2007, Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design, J Biol Chem, 282, 13648, 10.1074/jbc.M611711200 Vosbeck, 1971, The influence of antiandrogens on the excretion of FSH, LH, and 17-ketosteroids in males, Hormone Metab Res, 3, 273, 10.1055/s-0028-1094147 Laschet, 1975, Antiandrogens in the treatment of sexual deviations of men, J Steroid Biochem, 6, 821, 10.1016/0022-4731(75)90310-6 2007, Cyproterone acetate, medroxyprogesterone acetate, leuprolide, triptorelin, 1644 Jurzyk, 1992, Antiandrogens in the treatment of acne and hirsutism, Am Fam Physician, 45, 1803 Jungers, 1985, Hormone modulation in systemic lupus erythematosus. Preliminary clinical and hormone results with cyproterone acetate, Arthritis Rheum, 28, 1243, 10.1002/art.1780281108 Eriksson, 1998, Irradiation therapy prevents gynecomastia in sex offenders treated with antiandrogens, J Clin Psychiatry, 59, 432, 10.4088/JCP.v59n0806e Heinemann, 1997, Safety of cyproterone acetate: Report of active surveillance, Pharmacoepidemiol Drug Saf, 6, 169, 10.1002/(SICI)1099-1557(199705)6:3<169::AID-PDS263>3.0.CO;2-3 Miguel, 2007, Suspected cross-hepatotoxicity of flutamide and cyproterone acetate, Liver Int, 27, 1144, 10.1111/j.1478-3231.2007.01549.x Seaman, 2007, Venous thromboembolism and cyproterone acetate in men with prostate cancer: A study using the General Practice Research Database, BJU Int, 99, 1398, 10.1111/j.1464-410X.2007.06859.x Grasswick, 2003, Osteoporosis associated with the treatment of paraphilias: A clinical review of seven case reports, J Forensic Sci, 48, 849, 10.1520/JFS2002089 Unger, 1977, Cyproterone and hypersexuality, N Z Med J, 86, 39 2004 1998 2004 Løber, 1981, Pharmacokinetics of medroxyprogesterone acetate administered by oral and intramuscular route, Acta Obstet Gynecol Scand Suppl, 101, 71, 10.3109/00016348109157816 Camaggi, 1983, Medroxyprogesterone acetate (MPA) plasma levels after multiple high-dose administration in advanced cancer patients, Cancer Chemother Pharmacol, 11, 19, 10.1007/BF00257410 Antal, 1983, Influence of route of administration on the pharmacokinetics of medroxyprogesterone, J Pharmacokinet Biopharm, 11, 561, 10.1007/BF01059057 Kobayashi, 2000, Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate, Clin Cancer Res, 6, 3297 Blossey, 1982, The pharmacokinetics of high-dose medroxyprogesterone acetate (MPA) in the therapy of advanced breast cancer, Cancer Chemother Pharmacol, 8, 77, 10.1007/BF00292875 Stockdale, 1987, Medroxyprogesterone acetate: Variation in serum concentrations achieved with three commercially available preparations, Cancer Treat Rep, 71, 813 Rautio, 1984, Liver function and medroxyprogesterone acetate elimination in man, Biomed Pharmacother, 38, 199 Lønning, 1992, Clinical pharmacokinetics of endocrine agents used in advanced breast cancer, Clin Pharmacokinet, 22, 327, 10.2165/00003088-199222050-00002 Zhang, 2006, Inhibitory effects of medroxyprogesterone acetate on human liver cytochrome P450 enzymes, Eur J Clin Pharmacol, 62, 497, 10.1007/s00228-006-0128-9 Westhoff, 2007, Changes in weight with depot medroxyprogesterone acetate subcutaneous injection 104 mg/0.65 mL, Contraception, 75, 261, 10.1016/j.contraception.2006.12.009 Deen, 2007, Retinal venous occlusion associated with depot medroxyprogesterone acetate, Br J Ophthalmol, 91, 1254, 10.1136/bjo.2007.114322 Goldstein, 2007, Effect of depomedroxyprogesterone acetate on coagulation parameters: A pilot study, Fertil Steril, 87, 1267, 10.1016/j.fertnstert.2006.11.040 2008, 1136 2000 2006 2006 1993, Triptorelin pamoate, Phase III Drug Profiles, 3, 1 Geisthoevel, 1989, Monthly administration of the LH-RH analogue decapeptyl for longterm treatment of ovarian dysfunctions and estrogen-dependent disorders, Int J Fertil, 34, 262 Müller, 1997, Pharmacokinetics of triptorelin after intravenous bolus administration in healthy males and in males with renal or hepatic insufficiency, Br J Clin Pharmacol, 44, 335, 10.1046/j.1365-2125.1997.t01-1-00592.x Sennello, 1986, Single-dose pharmacokinetics of leuprolide in humans following intravenous and subcutaneous administration, J Pharm Sci, 75, 158, 10.1002/jps.2600750211 Potocnik, 1992, Successful treatment of hypersexuality in AIDS dementia with cyproterone acetate, S Afr Med J, 81, 433 Haussermann, 2003, Lowdose cyproterone acetate treatment of sexual acting out in men with dementia, Int Psychogeriatr, 15, 181, 10.1017/S104161020300886X Byrne, 1992, Cyproterone acetate therapy and aggression, Br J Psychiatry, 160, 282, 10.1192/bjp.160.2.282 Stewart, 2005, Optimizing antilibidinal treatment with medroxyprogesterone acetate, J Am Geriatr Soc, 53, 359, 10.1111/j.1532-5415.2005.53126_9.x Cooper, 1988, Medroxyprogesterone acetate as a treatment for sexual acting out in organic brain syndrome, Am J Psychiatry, 145, 1179, 10.1176/ajp.145.9.1179 Light, 2006, The use of medroxyprogesterone acetate for the treatment of sexually inappropriate behaviour in patients with dementia, J Psychiatry Neurosci, 31, 132 Amadeo, 1996, Antiandrogen treatment of aggressivity in men suffering from dementia, J Geriatr Psychiatry Neurol, 9, 142, 10.1177/089198879600900307 Cooper, 1987, Medroxyprogesterone acetate (MPA) treatment of sexual acting out in men suffering from dementia, J Clin Psychiatry, 48, 368 Weiner, 1992, Intramuscular medroxyprogesterone acetate for sexual aggression in elderly men, Lancet, 339, 1121, 10.1016/0140-6736(92)90723-G Kay, 1995, Transdermal estradiol in the management of aggressive behaviors in male patients with dementia, Clin Gerontol, 15, 54 Shelton, 1999, Estrogen for dementia-related aggression in elderly men, Ann Pharmacother, 33, 808, 10.1345/aph.18237 Kyomen, 1991, The use of estrogen to decrease aggressive physical behavior in elderly men with dementia, J Am Geriatr Soc, 39, 1110, 10.1111/j.1532-5415.1991.tb02878.x Rosenthal, 2003, Urethral masturbation and sexual disinhibition in dementia: A case report, Isr J Psychiatry Relat Sci, 40, 67 MacKnight, 2000, Quetiapine for sexually inappropriate behavior in dementia, J Am Geriatr Soc, 48, 707, 10.1111/j.1532-5415.2000.tb04737.x Stewart, 1997, Paroxetine treatment of sexual disinhibition in dementia, Am J Psychiatry, 154, 1474, 10.1176/ajp.154.10.1474a Leo, 1995, Clomipramine treatment of paraphilias in elderly demented patients, J Geriatr Psychiatry Neurol, 8, 123, 10.1177/089198879500800210 Simpson, 1986, Improvement in organically disturbed behavior with trazodone treatment, J Clin Psychiatry, 47, 191 Tiller, 1998, Short-term buspirone treatment in disinhibition with dementia, Lancet, 2, 510 Jensen, 1989, Hypersexual agitation in Alzheimer's disease, J Am Geriatr Soc, 37, 917, 10.1111/j.1532-5415.1989.tb02278.x Alkhalil, 2003, Can gabapentin be a safe alternative to hormonal therapy in the treatment of inappropriate sexual behavior in demented patients?, Int Urol Nephrol, 35, 299, 10.1023/B:UROL.0000020338.21912.c2 Freymann, 2005, Successful treatment of sexual disinhibition in dementia with carbamazepine\3-a case report, Pharmacopsychiatry, 38, 144, 10.1055/s-2005-864127 Alagiakrishnan, 2003, Role of cholinesterase inhibitor in the management of sexual aggression in an elderly demented woman, J Am Geriatr Soc, 51, 1326, 10.1046/j.1532-5415.2003.514204.x Wiseman, 2000, Hypersexuality in patients with dementia: Possible response to cimetidine, Neurology, 54, 2024, 10.1212/WNL.54.10.2024 Kyomen, 1997, Estrogen therapy decreases physically aggressive behaviors in elderly long-term care facility dementia patients: Results from a double-blind, placebo-controlled clinical trial, J Neuropsychiatry Clin Neurosci, 9, 174 Brantley, 1985, Antiandrogenic treatment of a gender-dysphoric transvestite, J Sex Marital Ther, 11, 109, 10.1080/00926238508406076 Huertas, 2007, Antiaggressive effect of cyproterone versus haloperidol in Alzheimer's disease: A randomized double-blind pilot study, J Clin Psychiatry, 68, 439, 10.4088/JCP.v68n0314 Clayton, 1993, Fetishism and clomipramine, Am J Psychiatry, 150, 673, 10.1176/ajp.150.4.673b Ward, 2007, Human rights and the treatment of sex offenders, Sex Abuse, 19, 195, 10.1177/107906320701900302 Weinberger, 2005, The impact of surgical castration on sexual recidivism risk among sexually violent predatory offenders, J Am Acad Psychiatry Law, 33, 16