Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
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Krude, H. et al. Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155–157 ( 1998).
Chagnon, Y.C. et al. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the quebec family study. Mol. Med. 3, 663–673 ( 1997).
Yeo, G.S.H. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genet. 20, 111–112 (1998).
Vaisse, C., Clement, K., Guy-Grand, B. & Froguel, P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet. 20, 113– 114 (1998).
Michaud, E.J. et al. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc. Natl Acad. Sci. USA 91, 2562–2566 (1994).
Ollmann, M.M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135–138 (1997).
Graham, M., Shutter, J.R., Sarmiento, U., Sarosi, I. & Stark, K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nature Genet. 17, 273–274 (1997).
Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131– 141 (1997).
Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165–168 (1997).
Lu, D. et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799– 802 (1994).
Marsh, D.J. et al. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nature Genet. 21, 119–122 (1999).
Chen, A.S. et al. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res. (in press).
Roselli-Rehfuss, L. et al. Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl Acad. Sci. USA 90, 8856– 8860 (1993).
Johnson, P.R. & Hirsch, J. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res. 13, 2–11 (1972).
Yen, T.T., Allan, J.A., Yu, P.-L., Acton, M.A. & Pearson, D.V. Triacylglycerol contents and in vivo lipogenesis of ob/ob, db/db and Avy/a mice. Biochem. Biophys. Acta 441, 213–220 ( 1976).
Yen, T.T., Steinmetz, J. & Wolff, G.L. Lipolysis in genetically obese and diabetes-prone mice. Horm. Metab. Res. 2, 200– 203 (1970).
Jones, B.H. et al. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am. J. Physiol. 270, E192–E196 (1996).
Xue, B., Moustaid-Moussa, N., Wilkison, W.O. & Zemel, M.B. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB 12, 1391–1396 (1998).
Fekete, C. et al. α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J. Neurosci. 20, 1550–1558 ( 2000).
Kim, M.S. et al. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J. Clin. Invest. 105, 1005–1011 ( 2000).
Frigeri, L.G., Wolff, G.L. & Teguh, C. Differential responses of yellow Avy/A and agouti A/a (BALB/c×VY) F1 hybrid mice to the same diets: glucose tolerance, weight gain, and adipocyte cellularity. Int. J. Obes. 12, 305–320 ( 1988).
Shimizu, H., Shargill, N.S., Bray, G.A., Yen, T.T. & Geselichen, P.D. Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci. 45, 543–552 ( 1989).
Hruby, V.J. et al. Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7, Lys10] α-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38 , 3454–3461 (1995).
Bagnol, D. et al. Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J. Neurosci. 19, RC26 (1–7) (1999).
Gantz, I. et al. Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268, 8246–8250 (1993).
Chhajlani, V. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem. Mol. Biol. Int. 38, 73–80 (1996).
Lembertas, A.V. et al. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J. Clin. Invest. 100, 1240–1247 (1997).
Guan, X.-M., Yu, H. & Van der Ploeg, L.H.T. Evidence of altered hypothalamic pro-opiomelanocortin/neuropeptide Y mRNA expression in tubby mice. Mol. Brain Res. 59 , 273–279 (1998).
Kelly, T.L., Berger, N. & Richardson, T.L. DXA body composition: theory and practice. Appl. Radiat. Isot. 49, 511–513 (1998).