Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate

Olivier Barbier1, Alain Bélanger
1Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center, Laval University, Québec, Canada.

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Tài liệu tham khảo

Hunter J. Observations on certain parts of the animal oeconomy. 1786;37.

White, 1895, I. The results of double castration in hypertrophy of the prostate, Annals of Surgery, 22, 1, 10.1097/00000658-189507000-00001

Ruzicka, 2001, The artificial preparation of the male sex hormone, Current Science, 80

Huggins, 1943, Endocrine control of prostatic cancer, Science, 97, 541, 10.1126/science.97.2529.541

Perez, 1985, Cancer of the prostate, 929

Labrie, 1982, New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen, Clinical and Investigative Medicine, 5, 267

Bruchovsky, 1968, The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate, The Journal of Biological Chemistry, 243, 5953, 10.1016/S0021-9258(18)94513-8

Labrie, 2005, Is dehydroepiandrosterone a hormone?, The Journal of Endocrinolology, 187, 169, 10.1677/joe.1.06264

1980

Mackenzie, 1997, The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence, Pharmacogenetics, 7, 255, 10.1097/00008571-199708000-00001

Tukey, 2000, Human UDP-glucuronosyltransferases: metabolism, expression, and disease, Annual Review of Pharmacology and Toxicology, 40, 581, 10.1146/annurev.pharmtox.40.1.581

Guillemette, 2004, Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview, Breast Cancer Research, 6, 246, 10.1186/bcr936

Belanger, 2003, Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans, Trends in Endocrinology and Metabolism, 14, 473, 10.1016/j.tem.2003.10.005

Turgeon, 2000, Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4, Journal of Molecular Biology, 295, 489, 10.1006/jmbi.1999.3374

Turgeon, 2001, Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members, Endocrinology, 142, 778, 10.1210/en.142.2.778

Chouinard, 2004, Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium, Endocrine Research, 30, 717, 10.1081/ERC-200044014

Belanger, 1994, Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men, The Journal of Clinical Endocrinology and Metabolism, 79, 1086, 10.1210/jc.79.4.1086

Vermeulen, 1991, Physiopathology of plasma androstanediol-glucuronide, The Journal of Steroid Biochemistry and Molecular Biology, 39, 829, 10.1016/0960-0760(91)90032-Z

Belanger, 1991, Steroid glucuronides: human circulatory levels and formation by LNCaP cells, The Journal of Steroid Biochemistry and Molecular Biology, 40, 593, 10.1016/0960-0760(91)90281-9

Pang, 1991, 3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion, The Journal of Clinical Endocrinology and Metabolism, 73, 166, 10.1210/jcem-73-1-166

Vexiau, 1990, Increase in plasma 5 alpha-androstane-3 alpha,17 beta-diol glucuronide as a marker of peripheral androgen action in hirsutism: a side-effect induced by cyclosporine A, Journal of Steroid Biochemistry, 35, 133, 10.1016/0022-4731(90)90157-N

Moghissi, 1984, Origin of plasma androstanediol glucuronide in men, Journal of Clinical Endocrinology & Metabolism, 59, 417, 10.1210/jcem-59-3-417

Labrie, 2006, Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women, The Journal of Steroid Biochemistry and Molecular Biology, 99, 182, 10.1016/j.jsbmb.2006.02.004

Vandenput, 2007, Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men, Journal of Bone and Mineral Research, 22, 220, 10.1359/jbmr.061018

Barbier, 2000, Cellular localization of uridine diphosphoglucuronosyltransferase 2B enzymes in the human prostate by in situ hybridization and immunohistochemistry, The Journal of Clinical Endocrinology and Metabolism, 85, 4819, 10.1210/jc.85.12.4819

Hum, 1999, Characterization of UDP-glucuronosyltransferases active on steroid hormones, The Journal of Steroid Biochemistry and Molecular Biology, 69, 413, 10.1016/S0960-0760(99)00061-8

Chouinard, 2006, Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation, Endocrinology, 147, 5431, 10.1210/en.2006-0229

Guillemette, 1996, Evidence for a role of glucuronosyltransferase in the regulation of androgen action in the human prostatic cancer cell line LNCaP, The Journal of Steroid Biochemistry and Molecular Biology, 57, 225, 10.1016/0960-0760(95)00258-8

Chouinard, 2007, UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells, The Journal of Biological Chemistry, 282, 33466, 10.1074/jbc.M703370200

Chen, 1993, Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms, Biochemistry, 32, 10648, 10.1021/bi00091a015

Levesque, 1997, Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene, Pharmacogenetics, 7, 317, 10.1097/00008571-199708000-00007

MacLeod, 2000, An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer, Annals of Surgical Oncology, 7, 777, 10.1007/s10434-000-0777-3

Hajdinjak, 2004, Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: Frequency of DD homozygotes increases with Gleason Score, Prostate, 59, 436, 10.1002/pros.20024

Park, 2004, Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer, The Journal of Urology, 171, 2484, 10.1097/01.ju.0000117748.44313.43

Okugi, 2006, Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population, Cancer Detection and Prevention, 30, 262, 10.1016/j.cdp.2006.04.004

Jakobsson, 2006, Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism, The Journal of Clinical Endocrinology and Metabolism, 91, 687, 10.1210/jc.2005-1643

Swanson, 2007, The UDP Glucuronosyltransferase 2B15 D85Y and 2B17 Deletion Polymorphisms Predict the Glucuronidation Pattern of Androgens and Fat Mass in Men, The Journal of Clinical Endocrinology and Metabolism, 92, 4878, 10.1210/jc.2007-0359

Park, 2007, Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk, Urology, 70, 374, 10.1016/j.urology.2007.03.001

Karypidis, 2007, Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate, The Pharmacogenomics Journal

Gallagher, 2007, The UGT2B17 gene deletion polymorphism and risk of prostate cancer A case-control study in Caucasians, Cancer Detection and Prevention, 31, 310, 10.1016/j.cdp.2007.07.005