Inactivation of Eed impedes MLL-AF9–mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model
Tài liệu tham khảo
Simon, 2012, A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia, Genes Dev, 26, 651, 10.1101/gad.186411.111
Muto, 2013, Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders, J Exp Med, 210, 2627, 10.1084/jem.20131144
Ntziachristos, 2012, Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia, Nat Med, 18, 298, 10.1038/nm.2651
Zhang, 2012, The genetic basis of early T-cell precursor acute lymphoblastic leukaemia, Nature, 481, 157, 10.1038/nature10725
Ernst, 2010, Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders, Nat Genet, 42, 722, 10.1038/ng.621
Nikoloski, 2010, Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes, Nat Genet, 42, 665, 10.1038/ng.620
Guglielmelli, 2011, EZH2 mutational status predicts poor survival in myelofibrosis, Blood, 118, 5227, 10.1182/blood-2011-06-363424
Shen, 2008, EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency, Mol Cell, 32, 491, 10.1016/j.molcel.2008.10.016
Neff, 2012, Polycomb repressive complex 2 is required for MLL-AF9 leukemia, Proc Natl Acad Sci U S A, 109, 5028, 10.1073/pnas.1202258109
Tanaka, 2012, Ezh2 augments leukemogenecity by reinforcing differentiation blockage in acute myeloid leukemia, Blood, 120, 1107, 10.1182/blood-2011-11-394932
Shi, 2012, The polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia, Oncogene, 32, 930, 10.1038/onc.2012.110
Kim, 2013, Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer, Nat Chem Biol, 9, 643, 10.1038/nchembio.1331
Xu, 2014, Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia, Blood, 125, 346, 10.1182/blood-2014-06-581082
Srinivas, 2001, Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus, BMC Dev Biol, 1, 4, 10.1186/1471-213X-1-4
Silver, 2001, Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity, Mol Cell, 8, 233, 10.1016/S1097-2765(01)00295-7
Subramanian, 2005, Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci U S A, 102, 15545, 10.1073/pnas.0506580102
Kim, 2010, A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs, Cell, 143, 313, 10.1016/j.cell.2010.09.010
Riddell, 2014, Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors, Cell, 157, 549, 10.1016/j.cell.2014.04.006
Bernt, 2011, MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L, Cancer Cell, 20, 66, 10.1016/j.ccr.2011.06.010
Wang, 2011, MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome, Blood, 117, 6895, 10.1182/blood-2010-12-324699
Bonadies, 2011, Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia, PLoS One, 6, e16330, 10.1371/journal.pone.0016330
Shih, 2015, Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia, Cancer Cell, 27, 502, 10.1016/j.ccell.2015.03.009
Tipping, 2009, High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle, Blood, 113, 2661, 10.1182/blood-2008-06-161117
Krivtsov, 2006, Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9, Nature, 442, 818, 10.1038/nature04980
Krivtsov, 2006, Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9, Nature, 442, 818, 10.1038/nature04980
Silver, 2001, Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity, Mol Cell, 8, 233, 10.1016/S1097-2765(01)00295-7
Naviaux, 1996, The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses, J Virol, 70, 5701, 10.1128/JVI.70.8.5701-5705.1996
Xie, 2014, Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner, Cell Stem Cell, 14, 68, 10.1016/j.stem.2013.10.001
Srinivas, 2001, Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus, BMC Dev Biol, 1, 4, 10.1186/1471-213X-1-4
Serrano, 1996, Role of the INK4a locus in tumor suppression and cell mortality, Cell, 85, 27, 10.1016/S0092-8674(00)81079-X
Pfaffl, 2001, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res, 29, e45, 10.1093/nar/29.9.e45
Wu, 2010, Fast and SNP-tolerant detection of complex variants and splicing in short reads, Bioinformatics, 26, 873, 10.1093/bioinformatics/btq057
Trapnell, 2013, Differential analysis of gene regulation at transcript resolution with RNA-seq, Nat Biotechnol, 31, 46, 10.1038/nbt.2450