Inactivation of Eed impedes MLL-AF9–mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model

Experimental Hematology - Tập 43 - Trang 930-935.e6 - 2015
Etienne Danis1,2, Taylor Yamauchi1,2, Kristen Echanique1,2, Jessica Haladyna1,2, Roshni Kalkur1,2, Simone Riedel1,2, Nan Zhu3,4, Huafeng Xie5,6, Kathrin M. Bernt1,2, Stuart H. Orkin5,6, Scott A. Armstrong3,4, Tobias Neff1,2
1Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA
2Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
3Human Oncology and Pathogenesis Program, Memorial Sloan–Kettering Cancer Center, Zuckerman Research Center, New York, NY, USA
4Leukemia Service, Department of Medicine, Memorial Sloan–Kettering Cancer Center, Zuckerman Research Center, New York, NY, USA
5Dana Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA
6Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA

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