In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds

Aderogba, 2013, Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii, Molecules, 18, 12633, 10.3390/molecules181012633 Altundağ, 2011, Ethnomedicinal studies on the plant resources of East Anatolia, Turkey, Procedia Soc. Behav. Sci., 19, 756, 10.1016/j.sbspro.2011.05.195 Aoudia, 2013, Phenolics, antioxidant and anti-inflammatory activities of Melia azedarach extracts, IJARNP, 6, 19 Barrantes, 2003, Inhibition of collagenase and metalloproteinases by aloins and aloe gel, Life Sci., 72, 843, 10.1016/S0024-3205(02)02308-1 Bani, 1996, Anti-inflammatory effects of an ethyl acetate extract of Euphorbia royleana, Phytother. Res., 10, 285, 10.1002/(SICI)1099-1573(199606)10:4<285::AID-PTR761>3.0.CO;2-P Barla, 2007, Screening of antioxidant activity of three Euphorbia species from Turkey, Fitoterapia, 78, 423, 10.1016/j.fitote.2007.02.021 Basma, 2011, Antioxidant activity and phytochemical screening of the methanol extracts of Euphorbia hirta L, Asian Pac. J. Trop. Med., 386, 10.1016/S1995-7645(11)60109-0 Battu, 2011, Evaluation of antioxidant and anti-inflammatory activity of Euphorbia heyneana Spreng, Asian Pac. J. Trop. Biomed., 201, 191, 10.1016/S2221-1691(11)60154-8 Bigoniya, 2007, Wound healing activity of Euphorbia neriifolia leaf ethanolic extract in rats, JNR, 7, 94 Cateni, 2003, New cerebrosides from Euphorbia peplis L.: antimicrobial activity evaluation, Bioorg. Med. Chem. Lett., 13, 4345, 10.1016/j.bmcl.2003.09.044 Cateni, 2014, Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L, Chem. Phys. Lipids, 181, 90, 10.1016/j.chemphyslip.2014.03.001 Davis, P.H., 1970. Flora of Turkey and the East Aegean Islands, vol. 7, Edinburgh. Değim, 2002, An investigation onskin wound healing in mice with a taurine-chitosan gel formulation, Amino Acids, 22, 187, 10.1007/s007260200007 Demirkıran, 2011, Structure elucidation of two new unusual monoterpene glycosides from Euphorbia decipiens, by 1D and 2D NMR experiments, Magn. Reson. Chem., 49, 673, 10.1002/mrc.2795 Fokialakis, 2003, Composition of the steam volatiles of six Euphorbia spp. from Greece, Flavour Frag. J., 18, 39, 10.1002/ffj.1148 Fraisse, 2000, Quercetin 3-arabinopyranoside, a major flavonoid compound from Alchemilla xanthochlora, Fitoterapia, 71, 463, 10.1016/S0367-326X(00)00145-3 George, 2014, Anti-inflammatory and wound healing properties of Rubus fairholmianus Gard. root-an in vivo study, Ind. Crops Prod., 54, 216, 10.1016/j.indcrop.2014.01.037 Giordani, 2001, Enhanced antifungal activity of ketoconazole by Euphorbia characias latex against Candida albicans, J. Ethnopharmacol., 1, 10.1016/S0378-8741(01)00295-1 Goyal, 2012, Wound healing activity of latex of Euphorbia caducifolia, J. Ethnopharmacol., 144, 786, 10.1016/j.jep.2012.10.006 Jaiprakash, 2006, Burn wound healing activity of Euphorbia hirta, Anc. Sci. Life, 25, 16 Jassbi, 2006, Chemistry and biological activity of secondary metabolites in Euphorbia from Iran, Phytochemistry, 67, 1977, 10.1016/j.phytochem.2006.06.030 Küpeli Akkol, 2011, Enhancement of wound healing by topical application of Scorzonera species: determination of the constituents by HPLC with a new validated reverse phase method, J. Ethnopharmacol., 137, 1018, 10.1016/j.jep.2011.07.029 Küpeli Akkol, 2012, Ethnopharmacological evaluation of some Scorzonera species: In vivo anti-inflammatory and antinociceptive effects, J. Ethnopharmacol., 140, 261, 10.1016/j.jep.2012.01.015 Küpeli Akkol, 2015, Bioassay-guided isolation and characterization of wound healer compounds from Morus nigra L. (Moraceae), Rec. Nat. Prod., 9, 484 Li, 2003, A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants, J. Ethnopharmacol., 85, 25, 10.1016/S0378-8741(02)00336-7 Lin, 1999, Flavonoids from the leaves of Loranthus kaoi (Chao) Kiu, J. Food Drug Anal., 7, 185 Lodhi, 2006, Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats, J. Ethnopharmacol., 108, 204, 10.1016/j.jep.2006.05.011 Lone, 2012, In vitro and in vivo anthelmintic activity of Euphorbia helioscopia L, Vet. Parasitol., 189, 317, 10.1016/j.vetpar.2012.04.023 Madureira, 2003, Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis, Nat. Prod. Res., 17, 375, 10.1080/14786410310001605841 Melzig, 2001, Inhibition of neutrophil elastase activity by phenolic compounds from plants, Pharmazie, 56, 967 Natarajan, 2005, Anti­bacterial activity of Euphorbia fusiformis-a rare medicinal herb, J. Ethnopharmacol., 123, 10.1016/j.jep.2005.04.023 Noori, 2009, Flavonoids of 17 species of Euphorbia (Euphorbiaceae) in Iran, Toxicol. Environ. Chem., 91, 631, 10.1080/02772240802389936 Patil, 2009, Review on phytochemistry and pharmacological aspects of Euphorbia hirta Linn, JPRHC, 1, 113 Pereira, 2012, Flavonoids and neolignan glucoside from Guarea macrophylla (Meliaceae), Quim. Nova, 35, 1123, 10.1590/S0100-40422012000600010 Polat, 2012, An ethnobotanical survey of medicinal plants in Edremit Gulf (Balıkesir- Turkey), J. Ethnopharmacol., 139, 626, 10.1016/j.jep.2011.12.004 Ramezani, 2008, Antiviral activity of Euphorbia helioscopia extract, J. Biol. Sci., 8, 809, 10.3923/jbs.2008.809.813 Sadaf, 2006, Healing potential of cream containing extract of Sphaeranthus indicuson dermal wounds in guinea pigs, J. Ethnopharmacol., 107, 161, 10.1016/j.jep.2006.02.022 Sahasrabudhe, 2010, Anti-hyaluronidase, anti-elastase activity of Garcinia indica, Int. J. Bot., 6, 299, 10.3923/ijb.2010.299.303 Sezik, 2001, Traditional medicine in Turkey X. Folk medicine in Central Anatolia, J. Ethnopharmacol., 75, 95, 10.1016/S0378-8741(00)00399-8 Sharma, 2014, Evaluation of the antioxidant, anti-Inflammatory, and anticancer activities of Euphorbia hirta ethanolic extract, Molecules, 19, 14567, 10.3390/molecules190914567 Shi, 2008, Chemical and pharmacological research of the plants in genus Euphorbia, Chem. Rev., 108, 4295, 10.1021/cr078350s Shih, 2010, A molecular pharmacology study into the anti-inflammatory actions of Euphorbia hirta L. on the LPS-induced RAW 264.7 cells through selective iNOS protein inhibition, J. Nat. Med., 64, 330, 10.1007/s11418-010-0417-6 Sudhakar, 2006, Antimicrobial activity of Caesalpinia pulcherrima, Euphorbia hirta and Asystasia gangeticum, Fitoterapia, 77, 378, 10.1016/j.fitote.2006.02.011 Suguna, 2002, Influence of Terminalia chebula on dermal wound healing in rats, Phytother. Res., 16, 227, 10.1002/ptr.827 Sulyok, 2011, New premyrsinane-type diterpene polyesters from Euphorbia falcata, Tetrahedron, 67, 7289, 10.1016/j.tet.2011.07.051 Süntar, 2010, Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin-3-O-glucoside, J. Ethnopharmacol., 129, 106, 10.1016/j.jep.2010.01.051 Süntar, 2012, Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: stepwise isolation of an active component by in vivo bioassay and its mode of activity, J. Ethnopharmacol., 143, 299, 10.1016/j.jep.2012.06.036 Süntar, 2013, Exploration of the wound healing potential of Helichrysum graveolens (Bieb.) sweet: isolation of apigenin as an active component, J. Ethnopharmacol., 149, 103, 10.1016/j.jep.2013.06.006 Tang, 2012, LC-MS method for detecting prostratin in plant extracts and identification of a high-yielding population of Euphorbia fischeriana, Phytochem. Lett., 214, 10.1016/j.phytol.2011.12.011 Tramontina, 2002, Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. histological and histometric findings, Braz. Dent. J., 13, 11 Whittle, 1964, The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics, Br. J. Pharmacol. Chemother., 22, 246, 10.1111/j.1476-5381.1964.tb02030.x Yasukawa, 2000, Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-o-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin, J. Pharm. Pharmacol., 52, 119, 10.1211/0022357001773607 Yesilada, 2007, Clematis vitalba L. aerial parts exhibit potent anti-inflammatory, antinociceptive and antipyretic effects, J. Ethnopharmacol., 110, 504, 10.1016/j.jep.2006.10.016 Yeşilada, 1999, Traditional medicine in Turkey IX: folk medicine in North-West Anatolia, J. Ethnopharmacol., 64, 195, 10.1016/S0378-8741(98)00133-0