In vivo optical coherence tomography for the diagnosis of oral malignancy

Lasers in Surgery and Medicine - Tập 35 Số 4 - Trang 269-275 - 2004
Petra Wilder‐Smith1, Woong Gyu Jung1, Matthew Brenner2, Kathryn Osann2, Hamza Beydoun1, Diana V. Messadi3, Zhongping Chen1
1Beckman Laser Institute, University of California, Irvine, California 92612
2University of California, Irvine, California 92612
3#TAB##TAB##TAB##TAB##TAB# University of California, Los Angeles, California 90095

Tóm tắt

AbstractBackground and ObjectiveOral cancer results in 10,000 U.S. deaths annually. Improved highly sensitive diagnostics allowing early detection of oral cancer would benefit patient survival and quality of life. Objective was to investigate in vivo non‐invasive optical coherence tomography (OCT) techniques for imaging and diagnosing neoplasia‐related epithelial, sub‐epithelial changes throughout carcinogenesis.Study Design/Materials and MethodsIn the standard hamster cheek pouch model for oral carcinogenesis (n = 36), in vivo OCT was used to image epithelial and sub‐epithelial change. OCT‐ and histopathology‐based diagnoses on a scale of 0 (healthy) to 6 (squamous cell carcinoma, SCC) were performed at all stages throughout carcinogenesis by two blinded investigators.ResultsEpithelial, sub‐epithelial structures were clearly discernible using OCT. OCT diagnosis agreed with the histopathological gold standard in 80% of readings.ConclusionIn vivo OCT demonstrates excellent potential as a diagnostic tool in the oral cavity. Lasers Surg. Med. 35:269–275, 2004. © 2004 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

American Cancer Society, 2000, American Cancer Society Report, 4

Regezi J, 1993, Oral pathology, 77

California Department of Health Services.Cancer Surveillance Section Annual Report March1999.

10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q

10.1364/OPN.8.5.000041

10.1364/OL.27.000243

10.1126/science.1957169

10.1364/OL.18.001864

10.1117/12.354807

10.1364/OL.20.001486

10.1111/1469-8986.00055

Milner TE, 1996, Optical coherence tomography, 220

10.1117/12.372915

10.1007/s005350050019

Bohorfoush AG, 2000, New diagnostic methods for esophageal carcinoma. Recent results, Cancer Res, 155, 55

10.1055/s-2000-7714

10.1117/1.1629680

10.1067/mge.2003.344

Chen Z, 2000, Phase‐resolved OCT/ODT for imaging tissue microcirculation, Proc SPIE, 3915, 413

10.1364/OL.22.001439

10.1364/OE.1.000424

10.1001/archopht.121.2.235

10.1364/OL.25.000114

10.1016/S0002-9149(99)00825-5

10.1016/S0002-9149(99)00825-5

10.1038/sj.neo.7900071

10.1053/gast.2001.20911

10.1067/mge.2002.120098

10.1364/OE.3.000257

10.1364/AO.37.003582

10.14219/jada.archive.2000.0210

10.1159/000061643

Matheny ES, 2003, Optical coherence tomography of malignant hamster cheek pouches, J Invest Med, 51, S78

10.1111/j.1600-0714.1981.tb01264.x

Wilder‐Smith P, 1999, Laser‐induced fluorescence for detection and diagnosis of oral malignancy, J Dent Res, 78, 820

Wilder‐Smith P, 1999, Topical ALA‐induced fluorescence in oral dysplasia and malignancy, Lasers Surg Med, 69, 39

10.1364/OL.22.001811

10.1364/OE.3.000219

Thông tin
Thông tin xuất bản

Lasers in Surgery and Medicine

Tập 35 Số 4

269-275

Thông tin tác giả