In vivo enhancement of angiogenesis by adenoviral transfer of HIF-1α-modified endothelial progenitor cells (Ad-HIF-1α-modified EPC for angiogenesis)

Abbott, 2004, Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury, Circulation, 110, 3300, 10.1161/01.CIR.0000147780.30124.CF Askari, 2003, Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy, Lancet, 362, 697, 10.1016/S0140-6736(03)14232-8 Belanger, 2002, Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (pgar) in cardiomyocytes: role of hypoxia inducible factor 1alpha, J Mol Cell Cardiol, 34, 765, 10.1006/jmcc.2002.2021 Brummelkamp, 2002, A system for stable expression of short interfering RNAs in mammalian cells, Science, 296, 550, 10.1126/science.1068999 Ceradini, 2005, Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue, Trends Cardiovasc Med, 15, 57, 10.1016/j.tcm.2005.02.002 Cosentino, 1998, Endothelial dysfunction in diabetes mellitus, J Cardiovasc Pharmacol, 3, S54 Couffinhal, 1998, Mouse model of angiogenesis, Am J Pathol, 152, 1667 Gerhard, 1996, Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans, Hypertension, 27, 849, 10.1161/01.HYP.27.4.849 Giaccia, 2003, HIF-1 as a target for drug development, Nat Rev Drug Discov, 2, 803, 10.1038/nrd1199 Gill, 2001, Vascular trauma induces rapid but transient mobilization of VEGFr2(+)ac133(+) endothelial precursor cells, Circ Res, 88, 167, 10.1161/01.RES.88.2.167 Jackson, 2001, Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells, J Clin Invest, 107, 1395, 10.1172/JCI12150 Jiang, 2002, Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha, Physiol Genomics, 8, 23, 10.1152/physiolgenomics.00058.2001 Jiang, 2006, Inhibition of hypoxia-inducible factor-1alpha and endothelial progenitor cell differentiation by adenoviral transfer of small interfering rna in vitro, J Vasc Res, 43, 511, 10.1159/000095964 Jiang, 2008, Angiogenesis by transplantation of HIF-1alpha modified EPCs into ischemic limbs, J Cell Biochem, 103, 321, 10.1002/jcb.21416 Kalka, 2000, Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization, Proc Natl Acad Sci USA, 97, 3422, 10.1073/pnas.070046397 Kawamoto, 2001, Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia, Circulation, 103, 634, 10.1161/01.CIR.103.5.634 Kollet, 2003, Hgf, sdf-1, and mmp-9 are involved in stress-induced human cd34+ stem cell recruitment to the liver, J Clin Invest, 112, 160, 10.1172/JCI17902 Lee, 2000, VEGF gene delivery to myocardium: deleterious effects of unregulated expression, Circulation, 102, 898, 10.1161/01.CIR.102.8.898 Lee, 2002, Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells, Nat Biotechnol, 20, 500, 10.1038/nbt0502-500 Lipinski, 2007, Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials, J Am Coll Cardiol, 50, 1761, 10.1016/j.jacc.2007.07.041 Manalo, 2005, Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1, Blood, 105, 659, 10.1182/blood-2004-07-2958 Meluzin J, Janousek S, Mayer J, Groch L, Hornacek I, Hlinomaz O, et al., Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction. Int J Cardiol; 2007. Miyagishi, 2002, U6 promoter-driven sirnas with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells, Nat Biotechnol, 20, 497, 10.1038/nbt0502-497 Miyagishi, 2003, Comparison of the suppressive effects of antisense oligonucleotides and sirnas directed against the same targets in mammalian cells, Antisense Nucleic Acid Drug Dev, 13, 1, 10.1089/108729003764097296 Murry, 2004, Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts, Nature, 428, 664, 10.1038/nature02446 Nwogu, 2001, Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction, Circulation, 104, 2216, 10.1161/hc4301.097193 Paddison, 2002, Short hairpin RNAs (shrnas) induce sequence-specific silencing in mammalian cells, Genes Dev, 16, 948, 10.1101/gad.981002 Paul, 2002, Effective expression of small interfering RNA in human cells, Nat Biotechnol, 20, 505, 10.1038/nbt0502-505 Peled, 1999, Dependence of human stem cell engraftment and repopulation of nod/scid mice on cxcr4, Science, 283, 845, 10.1126/science.283.5403.845 Schatteman, 2000, Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice, J Clin Invest, 106, 571, 10.1172/JCI9087 Semenza, 1994, Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1, J Biol Chem, 269, 23757, 10.1016/S0021-9258(17)31580-6 Shintani, 2001, Mobilization of endothelial progenitor cells in patients with acute myocardial infarction, Circulation, 103, 2776, 10.1161/hc2301.092122 Springer, 1998, VEGF gene delivery to muscle: potential role for vasculogenesis in adults, Mol Cell, 2, 549, 10.1016/S1097-2765(00)80154-9 Su, 2002, Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model, Proc Natl Acad Sci USA, 99, 9480, 10.1073/pnas.132275299 Sui, 2002, A DNA vector-based rnai technology to suppress gene expression in mammalian cells, Proc Natl Acad Sci USA, 99, 5515, 10.1073/pnas.082117599 Talks, 2000, The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages, Am J Pathol, 157, 411, 10.1016/S0002-9440(10)64554-3 Vasa, 2001, Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease, Circ Res, 89, E1, 10.1161/hh1301.093953 Vincent, 2000, Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/vp16 hybrid transcription factor, Circulation, 102, 2255, 10.1161/01.CIR.102.18.2255 Yamaguchi, 2003, Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization, Circulation, 107, 1322, 10.1161/01.CIR.0000055313.77510.22 Yeh, 2003, Transdifferentiation of human peripheral blood cd34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo, Circulation, 108, 2070, 10.1161/01.CIR.0000099501.52718.70 Yu, 2002, Rna interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells, Proc Natl Acad Sci USA, 99, 6047, 10.1073/pnas.092143499