In vivo efficacy of a unique first-in-class antibiofilm antibiotic for biofilm-related wound infections caused by Acinetobacter baumannii

Malone, 2017, The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data, J Wound Care, 26, 20, 10.12968/jowc.2017.26.1.20 James, 2008, Biofilms in chronic wounds, Wound Repair Regen, 16, 37, 10.1111/j.1524-475X.2007.00321.x Akers, 2014, Biofilms and persistent wound infections in United States military trauma patients: a case-control analysis, BMC Infect Dis, 14, 190, 10.1186/1471-2334-14-190 Sanchez, 2013, Biofilm formation by clinical isolates and the implications in chronic infections, BMC Infect Dis, 13, 47, 10.1186/1471-2334-13-47 Murray, 2008, Epidemiology of infections associated with combat-related injuries in Iraq and Afghanistan, J Trauma, 64, S232 Percival, 2015, Biofilms and wounds: an overview of the evidence, Adv Wound Care, 4, 373, 10.1089/wound.2014.0557 Sen, 2009, Human skin wounds: a major and snowballing threat to public health and the economy, Wound Repair Regen, 17, 763, 10.1111/j.1524-475X.2009.00543.x Bowler, 2003, The 105 bacterial growth guideline: reassessing its clinical relevance in wound healing, Ostomy/Wound Manag, 49, 44 Williams, 2011, Using biofilms as initial inocula in animal models of biofilm-related infections, J Biomed Mater Res B, 100, 1163, 10.1002/jbm.b.31979 Costerton, 2007, The predominance of biofilms in natural and engineered ecosystems, 5 Costerton, 1978, How bacteria stick, Sci Am, 238, 86, 10.1038/scientificamerican0178-86 Golovkine, 2017, Pseudomonas aeruginosa takes a multi-target approach to achieve junction breach, Frontiers in cellular and infection microbiology, 7, 532, 10.3389/fcimb.2017.00532 Borriello, 2004, Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms, Antimicrob Agents Chemother, 48, 2659, 10.1128/AAC.48.7.2659-2664.2004 Walters, 2003, Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin, Antimicrob Agents Chemother, 47, 317, 10.1128/AAC.47.1.317-323.2003 Haussener, 2016, A practical synthesis of N-alkyl- and N,N′-dialkyl-polyamines, Tetrahedron Lett, 57, 2845, 10.1016/j.tetlet.2016.05.034 Ashton, 2019, In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating, Acta Biomater, 93, 25, 10.1016/j.actbio.2019.02.010 Williams, 2019, In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection, Acta Biomater, 10.1016/j.actbio.2019.01.055 Zasloff, 1987, Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor, Proceedings of the National Academy of Sciences of the United States of America, 84, 5449, 10.1073/pnas.84.15.5449 Moore, 1993, Squalamine: an aminosterol antibiotic from the shark, Proc Natl Acad Sci Unit States Am, 90, 1354, 10.1073/pnas.90.4.1354 Dallo, 2010, Insights into acinetobacter war-wound infections, biofilms, and control, Adv Skin Wound Care, 23, 169, 10.1097/01.ASW.0000363527.08501.a3 Hujer, 2006, Analysis of antibiotic resistance genes in multidrug-resistant acinetobacter sp. isolates from military and civilian patients treated at the walter reed Army medical center, Antmicrob Agents Chemother, 50, 4114, 10.1128/AAC.00778-06 Williams, 2019, Growth substrate may influence biofilm susceptibility to antibiotics, PloS One, 14, 10.1371/journal.pone.0206774 Kirketerp-Møller, 2008, Distribution, organization, and ecology of bacteria in chronic wounds, J Clin Microbiol, 46, 2717, 10.1128/JCM.00501-08 Murray, 2006, Bacteriology of war wounds at the time of injury, Mil Med, 171, 826, 10.7205/MILMED.171.9.826 Williams, 2012, In vivo efficacy of a silicone - cationic steroid antimicrobial coating to prevent implant-related infection, Biomaterials, 33, 8641, 10.1016/j.biomaterials.2012.08.003 Williams, 2012, Experimental model of biofilm implant-related osteomyelitis to test combination biomaterials using biofilms as initial inocula, J Biomed Mater Res A, 100, 1888, 10.1002/jbm.a.34123 Marrie, 1982, A scanning and transmission electron microscopic study of an infected endocardial pacemaker lead, Circulation, 66, 1339, 10.1161/01.CIR.66.6.1339 Gristina, 1984, Bacteria-laden biofilms: a hazard to orthopedic prostheses, Infect Surg, 3, 655 Saye, 2007, Recurring and antimicrobial-resistant infections:considering the potential role of biofilms in clinical practice, Ostomy/Wound Manag, 53, 46 Krizek, 1967, Bacterial growth and skin graft survival, Surg Forum, 18, 518