In vivo demyelination by antimyelin antibodies
Tóm tắt
Central nervous system (CNS) myelinspecific antiserum was capable of initiating primary demyelination within 24 h following injection into the dorsal column of guinea pig spinal cord. Control serum injected in the same manner did not produce demyelination. The demyelinating lesions occurred as local linear plaques of completely denuded intact axons surrounded by partially demyelinated and myelinated normal axons. Antiserum-mediated demyelination was followed by mononuclear cell infiltration 7–10 days later. Ultrastructural examination revealed vesiculation of myelin followed by cleavage of myelin lamellae at the intraperiod line. Remyelination began between 7 and 10 days following injection and correlated well with clinical evidence of recovery. The results of this study point to the importance of circulating autimyelin antibodies in the pathogenesis of demyelinating encephalitis. The model represents an in vivo approach to the study of the pathogenesis of immune-mediated myelinolysis in demyelinating disorders like multiple sclerosis (MS), subacute sclerosing panencephalitis (SSPE), and canine distemper encephalitis (CDE).
Tài liệu tham khảo
Appel MGJ, Gillespie JJ (1972) Canine distemper virus. Virol Monogr 11:1
Bornstein MB (1963) A tissue culture approach to demyelinative disorders. Natl Cancer Inst Monograph 11:197
Bornstein MB, Appel SH (1961) The application of tissue culture to the study of experimental “allergic” encephalomyelitis. Part I (Patterns of demyelination). J Neuropathol Exp Neurol 20:141–157
Bornstein MB, Appei SH (1965) Tissue culture studies of demyelination. Ann NY Acad Sci 122:280
Bornstein MB, Iwanami H (1971) Experimental allergic encephalomyelitis. Demyelination activity of serum and sensitized lymph node cells on cultured nerve tissues. J Neuropathol Exp Neurol 30:240–248
Broman T (1949) The permeability of the cerebrospinal vessels in normal and pathological conditions. Munkogaard, Copenhagen
Dowling PC, Kim SU, Murray MR, Cook SD (1968) Serum 19S and 7S demyelinating antibodies in multiple sclerosis. J Immunol 101:1101–1104
Greenfield JG, Norman RM (1977) Demyelinating diseases. In: Blackwood W (ed.) Greenfield's neuropathology, 3rd edn. Amolil, London, pp 470–487
Hughes D, Field EJ (1967) Myelotoxicity of serum and spinal fluid in multiple sclerosis: A critical assessment. Clin Exp Immunol 2:295–298
Koestner A, McCullough B, Krakowka S, Long J, Olsen R (1974) Canine distemper: A virus induced demyelinating encephalomyelitis, in slow viruses. Zeman W, Lennette E, Brunson J (eds) Williams and Wilkins, Baltimore
Kristensson K, Wisniewski HM (1977) Chronic relapsing experimental allergic encephalomyelitis studies in vascular permeability changes. Acta Neuropathol (Berl) 39:189–194
Kristensson K, Wisniewski HM, Bornstein MB (1976) About demyelinating properties of humoral antibodies in experimental allergic encephalomyelitis. In vivo and in vitro studies. Acta Neuropathol (Berlin) 36:307–314
Krakowka GS, McCullough B, Koestner A, Olsen RG (1973) Myelin specific autoantibodies associated with central nervous system demyelination in canine distemper infection. Infect Immun 8:819–827
Lassman H, Wisniewski HM (1978) Chronic relapsing eae, time course of neurological symptoms and pathology. Acta Neuropathol 43:35–42
Lowry O, Rosenbrough N, Tarr A, Randall R (1971) J Biol Chem 193:265–275
Lumsden CE (1970) The neuropathology of multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 9. North Holland, Amsterdam, p 217
Lumsden CD (1971) The immunogenesis of the multiple sclerosis plaque. Brain Res 28:365–390
McCullough B, Krakowka S, Koestner A (1974) Experimental canine distemper virusinduced demyelination. Lab Invest 31:216–222
Pabst H, Dupuy JM (1970) Transfer of allergic encephalomyelitis with plasma factors (Abstract). Fed Proc 29:692
Parker JC, Klintworth GK, Graham DG, Griffith OF (1970) Uncommon morphologic features in subacute sclerosing panencephalitis (SSPE). Am J Pathol 61:275–291
Paterson PY (1960) Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J Exp Med 111:119–136
Prineas J (1972) Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis. Science 178:760–763
Prineas JW (1975) Pathology of the early lesion in multiple sclerosis. Human Pathol 6(s):531–534
Prineas JW, Raine CS (1976) Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions. Neurology (Minneap) 26:29–32
Prineas J, Raine CS, Wisniewski HM (1969) An ultrastructural study of experimental demyelination and remyelination, Part 3 (Chronic experimental allergic encephalomyelitis in the central nervous system). Lab Invest 21:472–483
Raine CS (1976) On the development of CNS lesions in natural canine distemper encephalomyelitis. J Neurol Sci 30:13–28
Raine CS, Bornstein MB (1970a) Experimental allergic encephalomyelitis. An ultrastructural study of experimental demyelination in vitro. J Neuropathol Exp Neurol 29:177–191
Raine CS, Bornstein MB (1970b) Experimental allergic encephalomyelitis. A light and electron microscope study of remyelination and “sclerosis” in vitro. J Neuropathol Exp Neurol 29:552–574
Raine CS, Hummelgard A, Swanson E, Bornstein MB (1973) Multiple sclerosis: Seruminduced demyelination in vitro. J Neurol Sci 20:127–148
Ross LL, Bornstein MB (1962) The application of tissue cultures to the study of experimental “allergic” encephalomyelitis, Part 3 (Electron microscopic observations of demyelination and remyelinization). Proceedings of the 4th International Congress of Neuropathologists, vol 2. Thieme, Stuttgart
Saida K, Saida T, Brown M, et al. (1978) Antiserum-mediated demyelination in vivo. Lab Invest 39:449–461
Toews A, Horrocks L, King J (1976) Simultaneous isolation of purified microsomal and myelin fractions from rat spinal cord. J Neurochem 27:25–31
Tourtilliote WW (1972) Interaction of local central nervous system immunity in the spread of multiple sclerosis demyelination. In: Wolegram F, Ellison GW, Stevens JG, Andrews JM (eds) Multiple sclerosis. Academic Press, New York, NY, pp 285–332
Wisniewski HM (1977) Immunopathology of demyelination. Br Med Bull 33:55–59
Wisniewski HM, Keith AB (1976) Chronic relapsing experimental allergic encephalomyelitis: An experimental model of multiple sclerosis. Ann Neurol 1:144–148
Wisniewski H, Prineas J, Raine CS (1969) An ultrastructural study of demyelination and remyelination, Part I. Lab Invest 21:105–118
Wisniewski HM, Raine CS, Kay WJ (1972) Observations on viral demyelinating encephalomyelitis canine distemper. Lab Invest 26:589–599
Zimmerman HM, Neisky MN (1950) The pathology of multiple sclerosis. Ass Res Nerv Ment Dis Proc 28:371–375