In vitro models for the blood–brain barrier

Artursson, 1996, Caco-2 monolayers in experimental and theoretical predictions of drug transport, Advanced Drug Delivery Reviews, 22, 67, 10.1016/S0169-409X(96)00415-2

Artursson, 1996, Studying transport processes in absorptive epithelia, 111

Brown, 2000, Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer derived epithelial cell line T24/83, Laboratory Investigation; A journal of technical methods and pathology, 80, 37, 10.1038/labinvest.3780006

Cecchelli, 1999, In vitro model for evaluating drug transport across the blood–brain barrier, Advanced Drug Delivery Reviews, 36, 165, 10.1016/S0169-409X(98)00083-0

Cornford, 1999, The carotoid artery single injection technique, 11

Curren, 1995, The role of prevalidation in the development, validation and acceptance of alternative methods, ATLA Alternatives to Laboratory Animals, 26, 211, 10.1177/026119299502300206

Dehouck, 1995, Drug transport to the brain: comparison between in vitro and in vivo models of the blood–brain barrier, European Journal of Biochemistry, 3, 357

Garberg, 1998, In vitro models of the blood–brain barrier, ATLA Alternatives to Laboratory Animals, 26, 821

Garberg, 1999, Automated absorption assessment using Caco-2 cells cultured on both sides of polycarbonate membranes, Pharmaceutical Research, 16, 441, 10.1023/A:1018838121975

Gumbleton, 2001, Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood–brain barrier, Journal of Pharmaceutical Sciencis, 90, 1681, 10.1002/jps.1119

Hurst, 1996, Properties of an immortalised vascular endothelial/Glioma cell co-culture model of the blood–brain barrier, Journal of Cell Physioliology, 167, 81, 10.1002/(SICI)1097-4652(199604)167:1<81::AID-JCP9>3.0.CO;2-8

Hurst, 1998, Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood–brain barrier model system, Brain Research, 802, 232, 10.1016/S0006-8993(98)00634-9

Janzer, 1987, Astrocytes induce blood–brain barrier properties in endothelial cells, Nature, 325, 253, 10.1038/325253a0

Kelder, 1999, Polar surface as a dominating determinant for oral absorption and brain penetration of drugs, Pharmaceutical Research, 16, 1514, 10.1023/A:1015040217741

Kuchler-Bopp, 1999, Astrocytes induce several blood–brain barrier properties in non-neural endothelial cells, Neuroreport, 10, 1347, 10.1097/00001756-199904260-00035

Lennernäs, 1996, Comparison between active and passive drug transport in human intestinal epithelial Caco-2 cell monolayers, International Journal of Pharmaceutics, 127, 103, 10.1016/0378-5173(95)04204-0

Lombardo, 1996, Computation of brain–blood partioning of organic solutes via free energy calculations, Journal of Medical Chemistry, 39, 4750, 10.1021/jm960163r

Lundquist, 2002, Prediction of drug transport through the blood–brain barrier in vivo: a comparison between two in vitro cell models, Pharmaceutical Research, 19, 976, 10.1023/A:1016462205267

Ohno, 1978, Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat, American Journal of Physiology, 235, H299

Österberg, 2001, Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD/logP and ACD/ChemSketch descriptors, European Journal of Pharmaceutical Sciences, 12, 327, 10.1016/S0928-0987(00)00189-5

Pardridge, 1997, Blood–brain barrier transport mechanisms, 21

Polli, 2000, A comparison of Madin–Darby canine kidney cells and bovine brain endothelial cells as a blood–brain barrier screen in early drug discovery, 271

Sjöberg, 1997, MOLSURF––a generator of chemical descriptors for QSAR, 83

Ståhle, 1991, A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis, Journal of Pharmacological Methods, 25, 41, 10.1016/0160-5402(91)90021-V

Stewart, 1981, Developing nervous tissue induces formation of blood–brain barrier characteristics in invading endothelial cells: a study using quail–chick transplantation chimeras, Developmental Biolology, 84, 183, 10.1016/0012-1606(81)90382-1

Taipalensuu, 2001, Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers, The Journal of Pharmacology and Experimental Therapeutics, 299, 164

Tan, 2001, A comparison of the induction of immortalized endothelial cell impermeability by astrocytes, Neuroreport, 12, 329, 10.1097/00001756-200105250-00008

Veronesi, 1996, Characterization of the MDCK cell line for screening of neurotoxicants, Neurotoxicology, 17, 433

Wold, 1984, The collinearity problem in linear regression: The partial least squares approach to generalized inverses. Society for Industrial and Applied Mathematics (SIAM), Journal on Scientific and Statistical Computing, 5, 743

Yamazaki, 2001, In vitro substrate identification studies for P-glycoprotein-mediated transport: species differences and predictability of in vivo results, The Journal of Pharmacology and Experimental Therapeutics, 296, 723

Yee, 1997, In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man––fact or myth, Pharmaceutical Research, 14, 763, 10.1023/A:1012102522787