In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo

Current Opinion in Toxicology - Tập 25 - Trang 15-22 - 2021
Jelle Vriend1, Keith R. Pye1, Colin Brown1
1Newcells Biotech, The Biosphere, Drayman’s Way, Newcastle Helix, Newcastle Upon Tyne, NE4 5BX, UK

Tài liệu tham khảo

Morrissey, 2013, Renal transporters in drug development, Annu Rev Pharmacol Toxicol, 53, 503, 10.1146/annurev-pharmtox-011112-140317 Cook, 2014, Lessons learned from the fate of astrazeneca's drug pipeline: a five-dimensional framework, Nat Rev Drug Discov, 13, 419, 10.1038/nrd4309 Ghane Shahrbaf, 2015, Drug-induced renal disorders, J Ren Inj Prev, 4, 57 Awdishu, 2017, The 6r's of drug induced nephrotoxicity, BMC Nephrol, 18, 124, 10.1186/s12882-017-0536-3 Paul, 2010, How to improve r&d productivity: the pharmaceutical industry's grand challenge, Nat Rev Drug Discov, 9, 203, 10.1038/nrd3078 Magee, 2013, Discovery of dap-3 polymyxin analogues for the treatment of multidrug-resistant gram-negative nosocomial infections, J Med Chem, 56, 5079, 10.1021/jm400416u 2020 2012 2018 Parvez, 2017, Evaluation of para-aminosalicylic acid as a substrate of multiple solute carrier uptake transporters and possible drug interactions with nonsteroidal anti-inflammatory drugs in vitro, Antimicrob Agents Chemother, 61, 10.1128/AAC.02392-16 Muller, 2017, Contribution of mate1 to renal secretion of the nmda receptor antagonist memantine, Mol Pharm, 14, 2991, 10.1021/acs.molpharmaceut.7b00179 Hotchkiss, 2015, Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines, Front Pharmacol, 6, 216, 10.3389/fphar.2015.00216 Li, 2013, Kinetic analysis of human and canine p-glycoprotein-mediated drug transport in mdr1-mdck cell model: approaches to reduce false-negative substrate classification, J Pharmaceut Sci, 102, 3436, 10.1002/jps.23523 Tahara, 2008, Directional transcellular transport of bisoprolol in p-glycoprotein-expressed llc-ga5-col150 cells, but not in renal epithelial llc-pk1 cells, Drug Metabol Pharmacokinet, 23, 340, 10.2133/dmpk.23.340 Jenkinson, 2012, The limitations of renal epithelial cell line hk-2 as a model of drug transporter expression and function in the proximal tubule, Pflügers Archiv, 464, 601, 10.1007/s00424-012-1163-2 Wilmer, 2010, Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters, Cell Tissue Res, 339, 449, 10.1007/s00441-009-0882-y Jansen, 2015, Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations, Sci Rep, 5, 16702, 10.1038/srep16702 Jansen, 2014, A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue, Exp Cell Res, 323, 87, 10.1016/j.yexcr.2014.02.011 Secker, 2019, Functional transepithelial transport measurements to detect nephrotoxicity in vitro using the rptec/tert1 cell line, Arch Toxicol, 93, 1965, 10.1007/s00204-019-02469-8 Nieskens, 2016, A human renal proximal tubule cell line with stable organic anion transporter 1 and 3 expression predictive for antiviral-induced toxicity, AAPS J, 18, 465, 10.1208/s12248-016-9871-8 Nieskens, 2018, Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity, Drug Metab Dispos, 46, 592, 10.1124/dmd.117.079384 Kuteykin-Teplyakov, 2010, Differences in the expression of endogenous efflux transporters in mdr1-transfected versus wildtype cell lines affect p-glycoprotein mediated drug transport, Br J Pharmacol, 160, 1453, 10.1111/j.1476-5381.2010.00801.x Jonker, 2003, Deficiency in the organic cation transporters 1 and 2 (oct1/oct2 [slc22a1/slc22a2]) in mice abolishes renal secretion of organic cations, Mol Cell Biol, 23, 7902, 10.1128/MCB.23.21.7902-7908.2003 Yonezawa, 2011, Importance of the multidrug and toxin extrusion mate/slc47a family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics, Br J Pharmacol, 164, 1817, 10.1111/j.1476-5381.2011.01394.x Basit, 2019, Kidney cortical transporter expression across species using quantitative proteomics, Drug Metab Dispos, 47, 802, 10.1124/dmd.119.086579 Brown, 2008, Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling, Toxicol Appl Pharmacol, 233, 428, 10.1016/j.taap.2008.09.018 Sanchez-Romero, 2020, A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy, Int J Artif Organs, 43, 45, 10.1177/0391398819866458 Bajaj, 2020, Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity, Toxicology, 442, 152535, 10.1016/j.tox.2020.152535 Bartels, 2020, Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: impact on safety assessments, Regul Toxicol Pharmacol, 116, 104714, 10.1016/j.yrtph.2020.104714 Little, 2019, Generating kidney from stem cells, Annu Rev Physiol, 81, 335, 10.1146/annurev-physiol-020518-114331 Takasato, 2015, Kidney organoids from human ips cells contain multiple lineages and model human nephrogenesis, Nature, 526, 564, 10.1038/nature15695 Hiratsuka, 2019, Induction of human pluripotent stem cells into kidney tissues by synthetic mrnas encoding transcription factors, Sci Rep, 9, 913, 10.1038/s41598-018-37485-8 Bajaj, 2018, Human pluripotent stem cell-derived kidney model for nephrotoxicity studies, Drug Metab Dispos, 46, 1703, 10.1124/dmd.118.082727 Czerniecki, 2018, High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping, Cell Stem Cell, 22, 929, 10.1016/j.stem.2018.04.022 Garreta, 2019, Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells, Nat Mater, 18, 397, 10.1038/s41563-019-0287-6 Schutgens, 2019, Tubuloids derived from human adult kidney and urine for personalized disease modeling, Nat Biotechnol, 37, 303, 10.1038/s41587-019-0048-8 Soo, 2018, Advances in predictive in vitro models of drug-induced nephrotoxicity, Nat Rev Nephrol, 14, 378, 10.1038/s41581-018-0003-9 Wilmer, 2016, Kidney-on-a-chip technology for drug-induced nephrotoxicity screening, Trends Biotechnol, 34, 156, 10.1016/j.tibtech.2015.11.001 Orosz, 2004, Growth, immortalization, and differentiation potential of normal adult human proximal tubule cells, In Vitro Cell Dev Biol Anim, 40, 22, 10.1290/1543-706X(2004)40<22:GIADPO>2.0.CO;2 Kaminski, 2016, Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors, Nat Cell Biol, 18, 1269, 10.1038/ncb3437 Jang, 2013, Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment, Integr Biol (Camb), 5, 1119, 10.1039/c3ib40049b Homan, 2016, Bioprinting of 3d convoluted renal proximal tubules on perfusable chips, Sci Rep, 6, 34845, 10.1038/srep34845 Lin, 2019, Renal reabsorption in 3d vascularized proximal tubule models, Proc Natl Acad Sci U S A, 116, 5399, 10.1073/pnas.1815208116 Jansen, 2016, Bioengineered kidney tubules efficiently excrete uremic toxins, Sci Rep, 6, 26715, 10.1038/srep26715 Weber, 2016, Development of a microphysiological model of human kidney proximal tubule function, Kidney Int, 90, 627, 10.1016/j.kint.2016.06.011 Chapron, 2020, An improved vascularized, dual-channel microphysiological system facilitates modeling of proximal tubular solute secretion, ACS Pharmacol Transl Sci, 3, 496, 10.1021/acsptsci.9b00078 Bhargava, 2017, Mitochondrial energetics in the kidney, Nat Rev Nephrol, 13, 629, 10.1038/nrneph.2017.107 Vormann, 2018, Nephrotoxicity and kidney transport assessment on 3d perfused proximal tubules, AAPS J, 20, 90, 10.1208/s12248-018-0248-z Vriend, 2018, Screening of drug-transporter interactions in a 3d microfluidic renal proximal tubule on a chip, AAPS J, 20, 87, 10.1208/s12248-018-0247-0 Vriend, 2020, Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia, Biochim Biophys Acta Gen Subj, 1864, 129433, 10.1016/j.bbagen.2019.129433 Sakolish, 2018, Technology transfer of the microphysiological systems: a case study of the human proximal tubule tissue chip, Sci Rep, 8, 14882, 10.1038/s41598-018-33099-2 Sakolish, 2020, Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling, Toxicol In Vitro, 63, 104752, 10.1016/j.tiv.2019.104752 van der Made, 2019, Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease, Mol Pharm, 16, 4551, 10.1021/acs.molpharmaceut.9b00681 Probst, 2018, High-throughput organ-on-a-chip systems: current status and remaining challenges, Curr Opin Biomed Eng, 6, 33, 10.1016/j.cobme.2018.02.004 Prasad, 2019, Toward a consensus on applying quantitative liquid chromatography-tandem mass spectrometry proteomics in translational pharmacology research: a white paper, Clin Pharmacol Ther, 106, 525, 10.1002/cpt.1537 Prasad, 2016, Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics, Drug Metab Dispos, 44, 1920, 10.1124/dmd.116.072066 Kumar, 2018, The importance of incorporating oct2 plasma membrane expression and membrane potential in ivive of metformin renal secretory clearance, Drug Metab Dispos, 46, 1441, 10.1124/dmd.118.082313 Scotcher, 2017, Microsomal and cytosolic scaling factors in dog and human kidney cortex and application for in vitro-in vivo extrapolation of renal metabolic clearance, Drug Metab Dispos, 45, 556, 10.1124/dmd.117.075242 Rodrigues, 2018, Endogenous probes for drug transporters: balancing vision with reality, Clin Pharmacol Ther, 103, 434, 10.1002/cpt.749 Chan, 2019, Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing, ALTEX, 36, 597 Arafa, 2015, Tmigd1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury, Am J Pathol, 185, 2757, 10.1016/j.ajpath.2015.06.006 Alvarez, 2016, Comparative characterization of shiga toxin type 2 and subtilase cytotoxin effects on human renal epithelial and endothelial cells grown in monolayer and bilayer conditions, PloS One, 11, 10.1371/journal.pone.0158180 Wieser, 2008, Htert alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics, Am J Physiol Ren Physiol, 295, F1365, 10.1152/ajprenal.90405.2008