In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment

Schaffner, 1982, Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes, J. Clin. Invest., 69, 617, 10.1172/JCI110489 Morgenstern, 1997, Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus, J. Exp. Med., 185, 207, 10.1084/jem.185.2.207 Mehrad, 1999, CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis, J. Immunol., 163, 6086, 10.4049/jimmunol.163.11.6086 Latge, 1999, Aspergillus fumigatus and aspergillosis, Clin. Microbiol. Rev., 12, 310, 10.1128/CMR.12.2.310 Gil-Lamaignere, 2005, Inteferon gamma and granulocyte-macrophage colony-stimulating factor augment the antifungal activity of human polymorphonuclear leukocytes against Scedosporium spp.: comparison with Aspergillus spp, Med. Mycol., 43, 253, 10.1080/13693780412331271072 Gordon, 2005, Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses, Infect. Immun., 73, 3445, 10.1128/IAI.73.6.3445-3452.2005 Hebart, 2002, Analysis of T-cell responses to Aspergillus fumigatus antigens in healthy individuals and patients with hematologic malignancies, Blood, 100, 4521, 10.1182/blood-2002-01-0265 Grazziutti, 1997, Aspergillus fumigatus conidia induce a Th1-type cytokine response, J. Infect. Dis., 176, 1579, 10.1086/514157 Bozza, 2003, A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation, Blood, 102, 3807, 10.1182/blood-2003-03-0748 Cenci, 1998, Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis, J. Infect. Dis., 178, 1750, 10.1086/314493 Schelenz, 1999, Cytokine and chemokine responses following pulmonary challenge with Aspergillus fumigatus: obligatory role of TNF-alpha and GM-CSF in neutrophil recruitment, Med. Mycol., 37, 183, 10.1046/j.1365-280X.1999.00219.x Morrison, 2003, Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis, J. Clin. Invest., 112, 1862, 10.1172/JCI18125 Mehrad, 2000, Macrophage inflammatory protein-1 alpha is a critical mediator of host defense against invasive pulmonary aspergillosis in neutropenic hosts, J. Immunol., 165, 962, 10.4049/jimmunol.165.2.962 Nessa, 1997, Reaction of human alveolar macrophages to exposure to Aspergillus fumigatus and inert particles, Environ. Res., 75, 141, 10.1006/enrs.1997.3788 Pylkkanen, 2004, Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages, Toxicology, 200, 255, 10.1016/j.tox.2004.03.019 Romani, 2004, Immunity to fungal infections, Nat. Rev. Immunol., 4, 1, 10.1038/nri1255 Bozza, 2002, Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus, J. Immunol., 168, 1362, 10.4049/jimmunol.168.3.1362 Gafa, 2006, Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response, Infect. Immun., 74, 1480, 10.1128/IAI.74.3.1480-1489.2006 Serrano-Gomez, 2005, DC-SIGN mediates the binding of Aspergillus fumigatus and keratinophylic fungi by human dendritic cells, Immunobiology, 210, 175, 10.1016/j.imbio.2005.05.011 Scimone, 2005, Migration of polymorphonuclear leucocytes is influenced by dendritic cells, Immunology, 114, 375, 10.1111/j.1365-2567.2005.02104.x Torosantucci, 1997, Responsiveness of human polymorphonuclear cells (PMNL) to stimulation by a mannoprotein fraction (MP-F2) of Candida albicans; enhanced production of IL-6 and tumour necrosis factor-alpha (TNF-alpha) by MP-F2-stimulated PMNL from HIV-infected subjects, Clin. Exp. Immunol., 107, 451, 10.1046/j.1365-2249.1997.2851176.x Pastor, 2006, Intracellular oxidative response of human monocytes and granulocytes to different strains of Aspergillus fumigatus, Mycoses, 49, 73, 10.1111/j.1439-0507.2006.01188.x Lande, 2003, IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells, J. Immunol., 170, 1174, 10.4049/jimmunol.170.3.1174 Ginis, 1997, Protection from apoptosis in human neutrophils is determined by the surface of adhesion, Am. J. Physiol., 272, C295, 10.1152/ajpcell.1997.272.1.C295 Walzog, 1997, Beta2 integrins (CD11/CD18) promote apoptosis of human neutrophils, FASEB J., 11, 1177, 10.1096/fasebj.11.13.9367353 Webb, 2005, The phenotype and function of lung dendritic cells, Crit. Rev. Immunol., 25, 465, 10.1615/CritRevImmunol.v25.i6.20 Lambrecht, 2001, Lung dendritic cells and host immunity to infection, Eur. Respir. J., 18, 692, 10.1183/09031936.01.18040692 Reynolds, 2000, Advances in understanding pulmonary host defense mechanisms: dendritic cell function and immunomodulation, Curr. Opin. Pulm. Med., 6, 209, 10.1097/00063198-200005000-00008 Cortez, 2006, Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus, Infect. Immun., 74, 2353, 10.1128/IAI.74.4.2353-2365.2006 Scapini, 2000, The neutrophil as a cellular source of chemokines, Immunol. Rev., 177, 195, 10.1034/j.1600-065X.2000.17706.x Kasama, 1993, Expression and regulation of human neutrophil-derived macrophage inflammatory protein 1 alpha, J. Exp. Med., 178, 63, 10.1084/jem.178.1.63 Akahoshi, 2003, Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens, Infect. Immun., 71, 524, 10.1128/IAI.71.1.524-526.2003 Scapini, 2002, CCL20/macrophage inflammatory protein-3alpha production in LPS-stimulated neutrophils is enhanced by the chemoattractant formyl-methionyl-leucyl-phenylalanine and IFN-gamma through independent mechanisms, Eur. J. Immunol., 32, 3515, 10.1002/1521-4141(200212)32:12<3515::AID-IMMU3515>3.0.CO;2-3 Bennouna, 2003, Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection, J. Immunol., 171, 6052, 10.4049/jimmunol.171.11.6052 Megiovanni, 2006, Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes, J. Leukoc. Biol., 79, 977, 10.1189/jlb.0905526 van Gisbergen, 2005, Y. van Kooyk, Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN, J. Exp. Med., 201, 1281, 10.1084/jem.20041276 Marr, 2002, Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients, Clin. Infect. Dis., 34, 909, 10.1086/339202 Mehrad, 1999, Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis, J. Immunol., 162, 1633, 10.4049/jimmunol.162.3.1633 de Jong, 2005, Dendritic cell-mediated T cell polarization, Springer Semin. Immunopathol., 26, 289, 10.1007/s00281-004-0167-1 Schutyser, 2003, The CC chemokine CCL20 and its receptor CCR6, Cytokine Growth Factor Rev., 14, 409, 10.1016/S1359-6101(03)00049-2 Fahy, 2004, Control of Salmonella dissemination in vivo by macrophage inflammatory protein (MIP)-3alpha/CCL20, Lab. Invest., 84, 1501, 10.1038/labinvest.3700176 Yang, 2003, Many chemokines including CCL20/MIP-3alpha display antimicrobial activity, J. Leukoc. Biol., 74, 448, 10.1189/jlb.0103024