In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres

Habraken, 2007, Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering, Adv Drug Deliv Rev, 59, 234, 10.1016/j.addr.2007.03.011 Sanzana, 2010, Of the in vivo behavior of calcium phosphate cements and glasses as bone substitutes, Acta Biomater, 4, 1924, 10.1016/j.actbio.2008.04.023 Zhang, 2006, In situ hardening hydroxyapatite-based scaffold for bone repair, J Mater Sci Mater Med, 17, 437, 10.1007/s10856-006-8471-z Takagi, 2001, Formation of macropores in calcium phosphate cement implants, J Mater Sci Mater Med, 12, 135, 10.1023/A:1008917910468 Xu, 2001, Strong and macroporous calcium phosphate cement: effects of porosity and fiber reinforcement on mechanical properties, J Biomed Mater Res, 57, 457, 10.1002/1097-4636(20011205)57:3<457::AID-JBM1189>3.0.CO;2-X Tajima, 2006, Fabrication of biporous low-crystalline apatite based on mannitol dissolution from apatite cement, Dent Mater J, 25, 616, 10.4012/dmj.25.616 Barralet, 2002, Preparation of macroporous calcium phosphate cement tissue engineering scaffold, Biomaterials, 23, 3063, 10.1016/S0142-9612(01)00401-X Gangfeng, 2009, Degradable and bioactive scaffold of calcium phosphate and calcium sulphate from self-setting cement for bone regeneration, J Porous Mater, 17, 605 del Real, 2002, A new method to produce macropores in calcium phosphate cements, Biomaterials, 23, 3673, 10.1016/S0142-9612(02)00101-1 Almirall, 2004, Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an alpha-TCP paste, Biomaterials, 25, 3671, 10.1016/j.biomaterials.2003.10.066 del Valle, 2007, In vivo evaluation of an injectable macroporous calcium phosphate cement, J Mater Sci Mater Med, 18, 353, 10.1007/s10856-006-0700-y del Real, 2003, In vivo bone response to porous calcium phosphate cement, J Biomed Mater Res A, 65, 30, 10.1002/jbm.a.10432 Lian, 2008, Mechanical properties and in vivo performance of calcium phosphate cement–chitosan fibre composite, Proc Inst Mech Eng H, 222, 347, 10.1243/09544119JEIM340 Girod Fullana, 2010, Controlled release properties and final macroporosity of a pectin microspheres–calcium phosphate composite bone cement, Acta Biomater, 6, 2294, 10.1016/j.actbio.2009.11.019 Habraken, 2008, Introduction of enzymatically degradable poly(trimethylene carbonate) microspheres into an injectable calcium phosphate cement, Biomaterials, 29, 2464, 10.1016/j.biomaterials.2008.02.012 LeGeros, 1993, Biodegradation and bioresorption of calcium phosphate ceramics, Clin Mater, 14, 65, 10.1016/0267-6605(93)90049-D Athanasiou, 1996, Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers, Biomaterials, 17, 93, 10.1016/0142-9612(96)85754-1 Iwasaki, 2002, Reduction of surface-induced inflammatory reaction on PLGA/MPC polymer blend, Biomaterials, 18, 3897, 10.1016/S0142-9612(02)00135-7 Kang, 2008, Apatite-coated poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for bone tissue engineering, J Biomed Mater Res A, 85, 747, 10.1002/jbm.a.31572 Li, 2007, Transfer of apatite coating from porogens to scaffolds: uniform apatite coating within porous poly(dl-lactic-co-glycolic acid) scaffold in vitro, J Biomed Mater Res A, 80, 226, 10.1002/jbm.a.31096 Lu, 2000, In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams, Biomaterials, 21, 1837, 10.1016/S0142-9612(00)00047-8 Heller, 2004, Drug delivery systems, 629 Cam, 1995, Degradation of high molecular weight poly(l-lactide) in alkaline medium, Biomaterials, 16, 833, 10.1016/0142-9612(95)94144-A Wu, 2001, Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers. Part II: Biodegradation, J Biomater Sci Polym Ed, 12, 21, 10.1163/156856201744425 Houchin, 2008, Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms, J Pharm Sci, 97, 2395, 10.1002/jps.21176 Tracy, 1999, Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro, Biomaterials, 20, 1057, 10.1016/S0142-9612(99)00002-2 Shive, 1997, Biodegradation and biocompatibility of PLA and PLGA microspheres, Adv Drug Deliv Rev, 28, 5, 10.1016/S0169-409X(97)00048-3 Alexis, 2005, Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly[(lactic acid)-co-(glycolic acid)], Polym Int, 54, 36, 10.1002/pi.1697 Komlev, 2002, Porous hydroxyapatite ceramics of bi-modal pore size distribution, J Mater Sci Mater Med, 13, 295, 10.1023/A:1014015002331 Simon, 2008, microCT analysis of hydroxyapatite bone repair scaffolds created via three-dimensional printing for evaluating the effects of scaffold architecture on bone ingrowth, J Biomed Mater Res A, 85, 371, 10.1002/jbm.a.31484 Liao, 2011, Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect, Acta Biomater, 7, 1752, 10.1016/j.actbio.2010.12.020 Habraken, 2006, Injectable PLGA microsphere/calcium phosphate cements: physical properties and degradation characteristics, J Biomater Sci Polym Ed, 17, 1057, 10.1163/156856206778366004 Spenlehauer, 1989, In vitro and in vivo degradation of poly(d,l lactide/glycolide) type microspheres made by solvent evaporation method, Biomaterials, 10, 557, 10.1016/0142-9612(89)90063-X Vert, 1998, Something new in the field of PLA/GA bioresorbable polymers?, J Control Release, 30, 85, 10.1016/S0168-3659(97)00240-X Wang, 1988, Tailored polymeric materials for controlled delivery systems, ACS Symp Ser, 709, 242, 10.1021/bk-1998-0709.ch019 Park, 1994, Degradation of poly(d,l-lactic acid) microspheres: effect of molecular weight, J Control Release, 30, 161, 10.1016/0168-3659(94)90263-1 Wiggins, 2006, Hydrolytic degradation of poly(d,l-lactide) as a function of end group: carboxylic acid vs. hydroxyl, Polymer, 47, 1960, 10.1016/j.polymer.2006.01.021 Qi, 2008, Improved injectability and in vitro degradation of a calcium phosphate cement containing poly(lactide-co-glycolide) microspheres, Acta Biomater, 4, 1837, 10.1016/j.actbio.2008.05.009 Fei, 2008, Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement, J Mater Sci: Mater Med, 19, 1109 Plachokova, 2007, Bone regenerative properties of injectable PGLA-CaP composite with TGF-beta1 in a rat augmentation model, J Tissue Eng Regen Med, 1, 457, 10.1002/term.59 Ruhé, 2005, Biocompatibility and degradation of poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites, J Biomed Mater Res A, 74, 533, 10.1002/jbm.a.30341 Bodde, 2008, The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats, J Biomed Mater Res A, 87, 780, 10.1002/jbm.a.31830 Bodde, 2009, Effect of polymer molecular weight on the bone biological activity of biodegradable polymer/calcium phosphate cement composites, Tissue Eng Part A, 15, 3183, 10.1089/ten.tea.2008.0694 Zolnik, 2007, Effect of acidic pH on PLGA microsphere degradation and release, J Control Release, 122, 338, 10.1016/j.jconrel.2007.05.034 Liu, 2006, Less harmful acidic degradation of poly(lactic-co-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition, Int J Nanomed, 1, 541, 10.2147/nano.2006.1.4.541 Yoon, 2008, Reduction of inflammatory reaction of poly(d,l-lactic-co-glycolic acid) using demineralized bone particles, Tissue Eng Part A, 14, 539, 10.1089/tea.2007.0129