In-vitro bactericidal and anti-oxidant efficacy of biosynthesized CuO/Cu2O-NiO nanocomposites against the pathogenic bacteria and DPPH free radical

Springer Science and Business Media LLC - Tập 6 Số 3
Kuldeep Kumar1, Rahul Kumar1, Rohit Jasrotia2, Susheel Kalia3, Vedpriya Arya4, Ashwani Kumar4, Rohit Khargotra5, Tej Singh6, Naveen Thakur7
1Department of Chemistry, Career Point University, Hamirpur, Himachal Pradesh 176041, India
2Faculty of Physics and Material Science, Shoolini University, Solan, Himachal Pradesh, 173229, India
3Department of Chemistry, ACC Wing (Academic Block) Indian Military Academy, Dehradun, Uttarakhand, 248007, India
4Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar, Uttarakhand, 249405, India
5Institute of Materials Engineering, Faculty of Engineering, University of Pannonia, Veszprém, 8200, Hungary
6Savaria Institute of Technology, Faculty of Informatics, ELTE Eötvös Loránd University, Budapest, 1117, Hungary
7Department of Physics, Career Point University, Hamirpur, Himachal Pradesh, 176041, India

Tóm tắt

Abstract

The biosynthesis of CuO/Cu2O-NiO nanocomposites with ratios of 90:10, 80:20, and 70:30 was conducted using Ipomoea carnea leaf extract. This study investigates, for the first time, the antioxidant and antibacterial activities of these nanocomposites against 1,1-diphenyl-2-picryl hydroxyl, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus pathogens. The antibacterial effect of 90:10 nanocomposites (NCs A1) was found to be enhanced compared to 80:20 (NCs B1) and 70:30 (NCs C1) due to particle aggregation, significant reactive oxygen species production, uniform quantum size, and ideal crystalline size. However, 70:30 nanocomposites (NCs C1) exhibited high radical scavenging activity (96.40%), surpassing ascorbic acid (98.63%). The current study revealed that Ipomoea carnea plant extract-based 90:10, 80:20, and 70:30 CuO/Cu2O-NiO NCs work as a new substitute for the currently utilized antibacterial agents, which are answerable for the multi-drug resistance in common bacteria for living beings and also used for biological importance as antibacterial agents in food packaging industries.

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