In vitro and in vivo safety studies of cinnamon extract ( Cinnamomum cassia ) on general and genetic toxicology

Akyıl, 2015, Detection of genotoxicity and mutagenicity of chlorthiophos using micronucleus, chromosome aberration, sister chromatid exchange, and ames tests, Environ. Toxicol., 30, 937, 10.1002/tox.21968 Blevins, 2007, Effect of Cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes, Diabetes Care, 30, 2236, 10.2337/dc07-0098 Broadhurst, 2000, Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro, J. Agric. Food Chem., 48, 849, 10.1021/jf9904517 Chen, 2013, Assessment of cisplatin-induced kidney injury using an integrated rodent platform, Toxicol. Appl. Pharmacol., 268, 352, 10.1016/j.taap.2013.01.032 Chung, 2013, Genotoxicity assessment of erythritol by using short-term assay, Toxicol. Res., 29, 249, 10.5487/TR.2013.29.4.249 Crawford, 2009, Effectiveness of Cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial, J. Am. Board Fam. Med., 22, 507, 10.3122/jabfm.2009.05.080093 Dhuley, 1999, Anti-oxidant effects of cinnamon (Cinnamomum verum) bark and greater cardamom (Amomum subulatum) seeds in rats fed high fat diet, Indian J. Exp. Biol., 37, 238 Eidi, 2012, Hepatoprotective activity of cinnamon ethanolic extract against CCl4-induced liver injury in rats, EXCLI J, 11, 495 Gandhi, 2003, Adverse drug events in ambulatory care, N. Engl. J. Med., 348, 1556, 10.1056/NEJMsa020703 Garriott, 2002, A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity, Mutat. Res., 517, 123, 10.1016/S1383-5718(02)00059-1 Hakura, 1999, Advantage of the use of human liver S9 in the Ames test, Mutat. Res., 438, 29, 10.1016/S1383-5718(98)00159-4 Han, 2011, Multienzyme-modified biosensing surface for the electrochemical analysis of aspartate transaminase and alanine transaminase in human plasma, Anal. Bioanal. Chem., 400, 797, 10.1007/s00216-011-4797-6 Heddle, 1984, 441 Iwata, 2016, The relation between hepatotoxicity and the total coumarin intake from traditional Japanese medicines containing cinnamon bark, Front. Pharmacol., 7, 174, 10.3389/fphar.2016.00174 Jain, 2015, Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats, Nutr. Neurosci., 18, 210, 10.1179/1476830514Y.0000000113 Jayaprakasha, 2006, Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity, J. Agric. Food Chem., 54, 1672, 10.1021/jf052736r Julianti, 2017, Antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria, Sci. Pharm., 85, 19, 10.3390/scipharm85020019 Kamei, 2000, The effect of a traditional Chinese prescription for a case of lung carcinoma, J. Altern. Complement Med, 6, 557, 10.1089/acm.2000.6.557 Kannappan, 2006, Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat, Singap. Med. J., 47, 858 Kanuri, 2009, Cinnamon extract protects against acute alcohol-induced liver steatosis in mice, J. Nutr., 139, 482, 10.3945/jn.108.100495 KFDA, 2014 Khan, 2003, Cinnamon improves glucose and lipids of people with type 2 diabetes, Diabetes Care, 26, 3215, 10.2337/diacare.26.12.3215 Kim, 2006, Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice, J. Ethnopharmacol., 104, 119, 10.1016/j.jep.2005.08.059 Kurokawa, 1998, Antipyretic activity of cinnamyl derivatives and related compounds in influenza virus-infected mice, Eur. J. Pharmacol., 348, 45, 10.1016/S0014-2999(98)00121-6 Kwon, 2009, Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells, Canc. Lett., 278, 174, 10.1016/j.canlet.2009.01.015 Kwon, 2010, Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1, BMC Canc., 10, 392, 10.1186/1471-2407-10-392 Lee, 1999, Inhibition of human tumor growth by 2'-hydroxy- and 2'-benzoyloxycinnamaldehydes, Planta Med., 65, 263, 10.1055/s-2006-960772 Lee, 2003, Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats, J. Med. Food, 6, 183, 10.1089/10966200360716599 Lee, 2006, Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells, Phytother Res., 20, 952, 10.1002/ptr.1984 Lee, 2005, Inhibitory effect of 2'-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells, Biochem. Pharmacol., 69, 791, 10.1016/j.bcp.2004.11.013 Lim, 2012, Subacute oral toxicity study of ethanolic leaves extracts of Strobilanthes crispus in rats, Asian Pac. J. Trop. Biomed, 2, 948, 10.1016/S2221-1691(13)60005-2 Liu, 2011, Angelica acutiloba root alleviates advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats, J. Food Sci., 76, H165, 10.1111/j.1750-3841.2011.02310.x Lorge, 2006, SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study, Mutat. Res., 607, 13, 10.1016/j.mrgentox.2006.04.006 Lu, 2011, Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks, Phytomedicine, 18, 298, 10.1016/j.phymed.2010.08.008 Lungarini, 2008, Coumarin and cinnamaldehyde in cinnamon marketed in Italy: a natural chemical hazard?, Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess, 25, 1297, 10.1080/02652030802105274 Mang, 2006, Effects of a Cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2, Eur. J. Clin. Invest., 36, 340, 10.1111/j.1365-2362.2006.01629.x Markman, 2002, Safety issues in using complementary and alternative medicine, J. Clin. Oncol., 20, 39 Maron, 1983, Revised methods for the mutagenicity test, Mutat. Res., 113, 173, 10.1016/0165-1161(83)90010-9 Matan, 2006, Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions, Int. J. Food Microbiol., 107, 180, 10.1016/j.ijfoodmicro.2005.07.007 Mroueh, 2004, Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats, Phytother Res., 18, 431, 10.1002/ptr.1498 Mukinda, 2007, Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents, J. Ethnopharmacol., 112, 138, 10.1016/j.jep.2007.02.011 NIH, 2015 NRC, 2010 OECD, 1997 OECD, 1997 OECD, 1998 OECD, 2008 Qin, 2003, Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats, Diabetes Res. Clin. Pract., 62, 139, 10.1016/S0168-8227(03)00173-6 Reagan-Shaw, 2008, Dose translation from animal to human studies revisited, FASEB J, 22, 659, 10.1096/fj.07-9574LSF Schoene, 2005, Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines, Canc. Lett., 230, 134, 10.1016/j.canlet.2004.12.039 Sheng, 2008, Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors, PPAR Res., 2008, 581348, 10.1155/2008/581348 Shin, 2013, Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague–Dawley rats, Food Chem. Toxicol., 55, 617, 10.1016/j.fct.2013.01.043 Singh, 2007, A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents, Food Chem. Toxicol., 45, 1650, 10.1016/j.fct.2007.02.031 Tomizawa, 2014, Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes, Biomed. Rep, 2, 633, 10.3892/br.2014.309 Tsuji-Naito, 2008, Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation, Bioorg. Med. Chem., 16, 9176, 10.1016/j.bmc.2008.09.036 Vaidya, 2010, Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies, Nat. Biotechnol., 28, 478, 10.1038/nbt.1623 Wojdyło, 2007, Antioxidant activity and phenolic compounds in 32 selected herbs, Food Chem., 105, 940, 10.1016/j.foodchem.2007.04.038 Worasuttayangkurn, 2012, Safety evaluation of longan seed extract: acute and repeated oral administration, Food Chem. Toxicol., 50, 3949, 10.1016/j.fct.2012.07.068 Youn, 2008, Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization, Biochem. Pharmacol., 75, 494, 10.1016/j.bcp.2007.08.033