In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts

Dennis Imhof1,2, Nicoleta Anghel1,2, Pablo Winzer1,2, Vreni Balmer1, Jessica Ramseier1, Kai Hänggeli1,2, Ryan Choi3, Matthew A. Hulverson3, Grant R. Whitman3, Samuel L.M. Arnold3,4, Kayode K. Ojo3, Wesley C. Van Voorhis3,5, J. Stone Doggett6, Luis M. Ortega-Mora7, Andrew Hemphill1
1Institute of Parasitology, Vetsuisse Faculty, University of Bern, Switzerland
2Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Switzerland
3Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
4Department of Pharmaceutics, University of Washington, Seattle, WA, USA
5Departments of Global Health and Microbiology, University of Washington, Seattle, WA, USA
6VA Portland Health Care System, Research and Development Service, Portland, OR, USA
7SALUVET, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, Madrid, Spain

Tài liệu tham khảo

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