Đề xuất bằng in silico để dự đoán cụm epitope của tế bào B và T nhằm thiết kế vắc xin từ các protein xâm nhập, độc lực và liên kết màng của C. jejuni
Tóm tắt
Trong nghiên cứu hiện tại, nhiều phương pháp miễn dịch thông tin đã được áp dụng để thiết kế một loại vắc xin dựa vào epitope tiềm năng chống lại
Các peptit “EINKN”, “TGSRLN”, “KSNPDI”, “LDENGCE” lần lượt từ các protein FlaA, MOMP, PEB3, CadF được phát hiện là những epitope tế bào B tiềm năng nhất, trong khi các peptit “FRINTNVAA”, “NYFEGNLDM”, “YKYSPKLNF”, “YQDAIGLLV”, “FRNNIVAFV” và “LIMPVFHEL” lần lượt từ Fla, CadF, MOMP, PEB1A, PEB3 và Cia có thể kích thích miễn dịch tế bào và “IFYTTGSRL” từ protein MOMP có thể kích thích cả miễn dịch dịch thể và tế bào. Tất cả các epitope peptid tiềm năng này đều cho thấy sự bảo tồn gần như 80–100% ở các chủng khác nhau của
Dựa trên nghiên cứu hiện tại, có thể kết luận rằng các epitope được dự đoán này có thể được sử dụng để thiết kế một loại vắc xin chống lại vi khuẩn
Từ khóa
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