Đánh giá tính sinh khả dụng và dược động học thuốc in silico của các sản phẩm tự nhiên từ cây thuốc ở vùng lưu vực Congo
Tóm tắt
Đánh giá chuyển hóa thuốc và dược động học (DMPK) đã trở thành một lĩnh vực quan tâm trong giai đoạn đầu của quá trình phát hiện thuốc hiện nay. Việc sử dụng mô hình hóa bằng máy tính để dự đoán các thuộc tính DMPK và độc tính của thư viện sản phẩm tự nhiên từ cây thuốc ở Trung Phi (được gọi là ConMedNP). Chất liệu từ một số nguồn cây hiện nay được sử dụng trong Y học cổ truyền châu Phi.
Các phương pháp dựa trên máy tính đang từ từ chiếm ưu thế trong lĩnh vực này và thường được sử dụng như là tiêu chí sơ bộ để loại bỏ các hợp chất có khả năng trình bày các hồ sơ dược động học không thú vị và mức độ độc tính không chấp nhận được trong danh sách các ứng viên thuốc tiềm năng, từ đó giảm chi phí phát hiện thuốc.
Trong nghiên cứu hiện tại, chúng tôi trình bày một đánh giá
Từ khóa
#Dược động học #chuyển hóa thuốc #sản phẩm tự nhiên #y học cổ truyền #cây thuốc #mô hình hóa máy tính.Tài liệu tham khảo
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