In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [14C]Procyanidin B2 in Male Rats

Drug Metabolism and Disposition - Tập 38 Số 2 - Trang 287-291 - 2010
Stavroula Stoupi1, Gary Williamson2, Florian Viton3, Denís Barron3, Laurence J. King4, Jonathan E. Brown4, Michael N. Clifford4
1Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.
2University of Leeds
3Nestlé Research Center
4#N#University of Surrey#N#

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10.1021/jf010965h

Baba, 2001, In vivo comparison of the bioavailability of (+)-catechin, (−)-epicatechin and their mixture in orally administered rats, J Nutr, 131, 2885, 10.1093/jn/131.11.2885

10.1016/S0891-5849(02)00871-7

Benet LZ Massoud N (1984) Pharmacokinetics, in Pharmacokinetic Basis for Drug Treatment ( Benet LZ Massoud N Gambertoglio JG eds) pp. 1–28, Raven, New York.

10.1080/0049825031000108315

10.1055/s-2004-835835

10.1006/taap.2000.8902

De Bruyne, 1999, Biological evaluation of proanthocyanidin dimers and related polyphenols, J Nat Prod, 62, 954, 10.1021/np980481o

Déprez, 2000, Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids, J Nutr, 130, 2733, 10.1093/jn/130.11.2733

10.1039/b008741f

Gonthier, 2003, Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols, J Nutr, 133, 461, 10.1093/jn/133.2.461

10.1016/S0891-5849(03)00394-0

10.3109/00498258709043949

Gu, 2004, Concentrations of proanthocyanidins in common foods and estimations of normal consumption, J Nutr, 134, 613, 10.1093/jn/134.3.613

10.3109/00498258209052486

10.1271/bbb.63.973

Harmand, 1978, The fate of total flavanolic oligomers (oft) extracted from Vitis vinifera l. in the rat, Eur J Drug Met Pharm, 3, 15, 10.1007/BF03189365

Holt, 2002, Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa, Am J Clin Nutr, 76, 798, 10.1093/ajcn/76.4.798

Rios, 2002, Cocoa procyanidins are stable during gastric transit in humans, Am J Clin Nutr, 76, 1106, 10.1093/ajcn/76.5.1106

10.1271/bbb.67.1140

10.1021/jf052260b

10.1007/s00394-005-0568-5

10.1006/bbrc.2001.5211

Stoupi, 2009, A comparison of the biotransformation of (−)-epicatechin and procyanidin B2 by human colonic bacteria, Mol Nutr Food Res, 53, 1

10.1079/BJN20051480

Viton, 2008, First total synthesis of 14C-labeled procyanidin B2—a milestone toward understanding cocoa polyphenol metabolism, Eur J Org Chem, 36, 6069, 10.1002/ejoc.200800886

Williamson, 2005, Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies, Am J Clin Nutr, 81, 243S, 10.1093/ajcn/81.1.243S