In Vitro Hepatic Oxidative Biotransformation of Trimethoprim

Drug Metabolism and Disposition - Tập 43 Số 9 - Trang 1372-1380 - 2015
Jennifer Goldman1, J. Steven Leeder1, Leon van Haandel1, Robin E. Pearce1
1Divisions of Clinical Pharmacology, Toxicology and Therapeutic Innovation (J.L.G., J.S.L., L.V.H., R.E.P.) and Infectious Diseases (J.L.G.), Departments of Pediatrics (J.L.G., J.S.L., L.V.H., R.E.P.) and Pharmacology (J.S.L. R.E.P.), Children's Mercy Hospital, University of Missouri, Kansas City, Missouri

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1002/jps.2600620849

10.1021/tx900034r

10.2174/138920009789375397

10.1136/adc.87.6.462

10.1542/peds.2010-3465

Cuttle, 2000, Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation, Drug Metab Dispos, 28, 945

10.1021/tx8002593

10.1097/00008571-199902000-00007

10.1111/j.1600-0773.1998.tb01427.x

Hawkins, 1993, Severe trimethoprim induced neutropenia and thrombocytopenia, N Z Med J, 106, 251

10.1001/archinte.168.14.1585

10.1002/jbt.20179

10.1159/000238282

10.1016/j.clpt.2004.08.009

Lai, 1999, Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes, J Pharmacol Exp Ther, 291, 292

10.1002/rcm.4507

10.1124/mol.62.5.1011

Mofenson, 2009, Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics, MMWR Recomm Rep, 58, 1

Mortimer, 2005, Fatal adverse drug reaction to trimethoprim, Aust Fam Physician, 34, 345

10.1124/mol.62.3.628

10.1136/bmj.296.6627.970

Parkinson A (1996) Biotransformation of xenobiotics, in Casarett and Doull's Toxicology ( Klaassen CD ed), McGraw-Hill, New York 113–186.

10.1124/dmd.107.019562

10.1056/NEJM199512143332404

10.1136/adc.60.1.29

10.1093/infdis/128.Supplement_3.S580

10.1021/tx4003325

10.1124/dmd.30.6.631

10.1038/clpt.2014.129