Improving preclinical models of HIV microbicide efficacy

Abdool Karim, 2010, Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women, Science, 329, 1168, 10.1126/science.1193748 Parrish, 2013, Phenotypic properties of transmitted founder HIV-1, Proc. Natl. Acad. Sci. U.S.A., 110, 6626, 10.1073/pnas.1304288110 Del Prete, 2014, Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins, Cell Host Microbe, 16, 412, 10.1016/j.chom.2014.08.003 Munch, 2007, Semen-derived amyloid fibrils drastically enhance HIV infection, Cell, 131, 1059, 10.1016/j.cell.2007.10.014 Kim, 2010, Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI, Retrovirology, 7, 55, 10.1186/1742-4690-7-55 Roan, 2011, Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection, Cell Host Microbe, 10, 541, 10.1016/j.chom.2011.10.010 Zirafi, 2014, Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides, Sci. Transl. Med., 6, 262ra157, 10.1126/scitranslmed.3009634 Fichorova, 2011, Novel vaginal microflora colonization model providing new insight into microbicide mechanism of action, MBio, 2, 10.1128/mBio.00168-11 Lackman-Smith, 2008, Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides, Antimicrob. Agents Chemother., 52, 1768, 10.1128/AAC.01328-07 Doncel, 2010, Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers, Antiviral Res., 88, S10, 10.1016/j.antiviral.2010.09.018 Denton, 2012, Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice, Trends Microbiol., 20, 268, 10.1016/j.tim.2012.03.007 Sabatte, 2007, Human seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN, J. Virol., 81, 13723, 10.1128/JVI.01079-07 Miller, 1994, Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia, J. Virol., 68, 6391, 10.1128/JVI.68.10.6391-6400.1994 Neildez, 1998, Variation in virological parameters and antibody responses in macaques after atraumatic vaginal exposure to a pathogenic primary isolate of SIVmac251, Res. Virol., 149, 53, 10.1016/S0923-2516(97)86900-2 Munch, 2013, Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus, Retrovirology, 10, 148, 10.1186/1742-4690-10-148