Improved hemodialysis with hemocompatible polyethersulfone hollow fiber membranes: In vitro performance

Journal of Biomedical Materials Research - Part B Applied Biomaterials - Tập 106 Số 3 - Trang 1286-1298 - 2018
Surendra Kumar Verma1, Akshay Modi1, Atul Kumar Singh2, Rohit Teotia3, Jayesh Bellare1
1Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India
2Centre for Research in Nanotechnology and Science, Indian Institute of Technology Bombay, Mumbai 400076, India
3Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India

Tóm tắt

AbstractWe show that addition of nanozeolite (NZ) and vitamin E D‐α‐Tocopherol polyethylene glycol succinate (TPGS or T) considerably improves the performance of polyethersulfone (PES or P) hollow fiber membrane (HFM) for hemodialysis. Nanocomposite HFMs were manufactured using PES as a polymer, TPGS as an additive and NZ as a filler to give a composite membrane called PT‐NZ. HFMs were spun by dry‐wet spinning principle based on liquid‐liquid phase separation. TPGS and NZ were successfully incorporated in HFMs, as confirmed by EDX elemental mapping. The resultant PT‐NZ HFMs had improved hemocompatibility: lower percent hemolysis (0.28% in batch mode and 0.32% in continuous mode), lower platelet adhesion, higher coagulation time and lower protein adsorption (16.34 µg/cm2), compared with P, PT, and commercial (F60S) HFMs. The ultrafiltration coefficient of PT‐NZ HFM‐based module (274.59 mL/m2/h/mmHg) was ∼1.5‐times higher than that of F60S membranes (151.67 mL/m2/h/mmHg), and the solute rejection of both the membranes was comparable. The toxin clearance performance of lab‐scale PT‐NZ HFM‐based hemodialyzer with uremic toxin spiked goat blood was remarkably higher (five times) than that of F60S. Hence, the synthesized PT‐NZ HFMs are a potentially attractive membrane material for hemodialysis application, particularly due to decreased treatment time and minimal side reactions. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1286–1298, 2018.

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Tài liệu tham khảo

10.1016/S0140-6736(11)60178-5

10.1053/j.ackd.2011.09.001

10.1016/j.memsci.2007.05.012

10.1007/s10856-007-3006-9

Saito A, 2012, High‐performance membrane dialyzers, Kidney Blood Press Res, 35, 299

10.1007/978-3-319-12478-0

10.1159/000328954

10.1016/j.memsci.2006.03.010

10.1007/s10047-008-0417-4

Idris A, 2008, Effect of monosodium glutamate additive on performance of dialysis membrane, J Eng Sci Technol, 3, 172

Li S, 2011, Preparation and characteristics of polysulfone dialysis composite membranes modified with nanocrystalline cellulose, Bioresources, 6, 1670, 10.15376/biores.6.2.1670-1680

Idris A, 2012, Preparation of cellulose acetate dialysis membrane using D–glucose monohydrate as additive, J. Teknol., 51, 67

10.1016/j.biomaterials.2010.09.005

10.1016/j.cej.2012.05.037

10.1002/app.34998

10.1039/C4RA13460E

10.1007/s00396-015-3801-7

10.1046/j.1537-2995.2001.41121606.x

10.1016/S0376-7388(00)00340-9

Peinemann K.‐V, 2011, Membrane Technology, Volume 1: Membranes for Life Sciences

10.3109/00365513.2011.558106

10.1016/j.biomaterials.2003.08.027

10.1016/j.biomaterials.2004.04.039

10.1016/j.memsci.2012.03.015

10.1039/C5RA16515F

10.1039/C6RA13293F

10.1007/s12221-009-0001-4

GuytonAC.Human physiology and mechanisms of disease. WB Saunders Co 1992.

10.1111/j.1749-6632.1987.tb33038.x

10.1146/annurev.ms.26.080196.002053

10.1097/00002480-199339040-00027

10.17795/nmsjournal21764

Mandelbrot D. High‐flux dialysis. The kidney transplant/dialysis association patient handbook.1999.

10.1002/app.1994.070540313

10.1021/ie9018963

10.3390/membranes5010120

10.3390/membranes6040045

10.1080/00914030903081521

10.1002/jbm.a.35986

Mashita T, 1997, Short‐term hemodialysis treatment in dogs and cats with total uretic obstruction, Jpn J Vet Res, 45, 59

Stanley SW, 2008, Hemodialysis in a dog with acute renal failure from currant toxicity, Can Vet J, 49, 63

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Journal of Biomedical Materials Research - Part B Applied Biomaterials

Tập 106 Số 3

1286-1298

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