Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles

C. Bothiraja1, Atmaram Pawar1
1Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, Maharashtra, 411038, India

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Bothiraja C, Shinde MB, Rajalakshmi S, Pawar AP (2009a) Evaluation of molecular pharmaceutical and in vivo properties of spray-dried isolated andrographolide-PVP. J Pharm Pharmacol 61:1465–1472

Bothiraja C, Pawar AP, Shaikh KS, Sher P (2009b) Eudragit EPO based nanoparticles suspension of andrographolide: in vitro and in vivo. Nanosci Nanotechnol Lett 10:156–164

Calabrese C, Berman SH, Babish JG, Ma X, Shinto L, Dorr M, Wells K, Wenner CA, Standish LJ (2000) A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytotherapy Res 14:333–338

El-Shabouri MH (2002) Positively charged nanoparticles for improving the oral bioavailability of cyclosporine A. Int J Pharm 249:101–108

Galindo-Rodriguez S, Allemann E, Fessi H, Doelker E (2004) Physicochemical parameters associated with nanoparticle formation in the salting out, emulsification-diffusion and nanoprecipitation methods. Pharm Res 21:1428–1439

Jaeghere FD, Allemann E, Kubel F, Galli B, Cozens R, Doelker E (2000) Oral bioavailability of a poorly water soluble HIV-I protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state. J Control Release 68: 291–198

Jayanta S (2000) Targeting of liposomal andrographolide to L. donovani-infected macrophages in vivo. Drug Discovery 7:209–213

Jiao Y, Ubrich N, Marchand AM, Vigneron C, Hoffman M, Lecompte T, Maincent P (2002) In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 105:230–235

Klipatein FA, Engert RF, Sherman WT (1983) Peroral immunization with Escherichia coli heat-labile enterotoxin delivery by microspheres. Infect Immun 39:1000–1003

Kocbek P, Baumgartner S, Kristl J (2006) Preparation and evaluation of nanosuspension for enhancing the dissolution of poorly soluble drugs. Int J Pharm 312:179–186

Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A, Nish K (1994) Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo) 42:1216–1225

McClean S, Prosser E, Meehan E, O’Malley D, Clarke N, Ramtoola Z, Brayden D (1998) Binding and uptake of biodegradable poly-dl-lactide micro-and nanoparticles in intestinal epithelia. Eur J Pharm Sci 6:153–163

Morishita I, Morishita M, Takayama K, Machida Y, Nagai T (1993) Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100. Int J Pharm 91:29–37

Panossian A, Hovhannisyan A, Mamikonyan G, Abrahamian H, Hambardzumyan E, Gabrielian E, Goukasova G, Wikman G, Wagner H (2000) Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 7:351–364

Shenv YC, Chen CF, Chiou WF (2002) Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti- inflammatory effect. Br J Pharmacol 135:399–406

Somenath R, Prajjal KS, Satyahari D (2007) Protective activity of andrographolide and arabinogalactan protein from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. J Ethnopharmacol 111:13–21

Suo XB, Zhang H, Wang YQ (2007) HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in liposomes and tablets. Biomed Chromatogr 21:730–734

Thamlikitkul V, Dechatiwongse T, Theerapong S (1991) Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 74:437–442

Thanou M, Verhoef JC, Junginger HE (2001) Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 52:117–126

Ubrich N, Schmidt C, Bodmeier R, Hoffman M, Maincent P (2005) Oral evaluation in rabbits of cyclosporin-loaded Eudragit® RS or RL nanoparticles. Int J Pharm 288:169–175

Zhang XF, Tan BK (2000) Antihyperglycemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clin Exp Pharmacol Physiol 27:358–363

Zhao HY, Fang WY (1991) Antithrombotic effects of Andrographis paniculata Nees in preventing myocardial infarction. Chin Med J 104:770–775

Zhao DY, Liao KJ, Ma XY, Yan XH (2002) Computational study on the molecular inclusion of andrographolide by cyclodextrin. J Incl Phenom 43:259–264

Zhao YH, Abraham MH, Le J, Hersey A, Luscombe CN, Beck G, Sherborne B, Cooper I (2003) Evaluation of intestinal absorption data and correlation with human intestinal absorption. Eur J Med Chem 38:233–243