Importance of TLR2 on Hepatic Immune and Non-Immune Cells to Attenuate the Strong Inflammatory Liver Response During Trypanosoma cruzi Acute Infection

E Seki, 2008, Toll-like receptors and adaptor molecules in liver disease: update., Hepatology, 48, 322, 10.1002/hep.22306

B Gao, 2008, Liver: An organ with predominant innate immunity., Hepatology, 47, 729, 10.1002/hep.22034

IN Crispe, 2009, The liver as a lymphoid organ., Annu Rev Immunol, 27, 147, 10.1146/annurev.immunol.021908.132629

H Jaeschke, 2006, Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions., Am J Physiol Gastrointest Liver Physiol, 290, G1083, 10.1152/ajpgi.00568.2005

MJ Scott, 2009, Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism., Hepatology, 49, 1695, 10.1002/hep.22839

E Seki, 2007, TLR4 enhances TGF-beta signaling and hepatic fibrosis., Nat Med, 13, 1324, 10.1038/nm1663

S Liu, 2002, Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide., Infect Immun, 70, 3433, 10.1128/IAI.70.7.3433-3442.2002

MS Duthie, 2005, Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection., Infect Immun, 73, 181, 10.1128/IAI.73.1.181-192.2005

GA Garcia, 2006, Immunological and pathological responses in BALB/c mice induced by genetic administration of Tc 13 Tul antigen of Trypanosoma cruzi., Parasitology, 132, 855, 10.1017/S0031182005009753

B Bouzahzah, 2006, Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection., Cell Cycle, 5, 2396, 10.4161/cc.5.20.3380

LR Sardinha, 2006, Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi., Infect Immun, 74, 2031, 10.1128/IAI.74.4.2031-2042.2006

MT Ronco, 2010, Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice., Cytokine, 49, 64, 10.1016/j.cyto.2009.09.012

EA Carrera-Silva, 2008, TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection., Mol Immunol, 45, 3580, 10.1016/j.molimm.2008.05.004

OM Grauer, 2008, TLR ligands in the local treatment of established intracerebral murine gliomas., J Immunol, 181, 6720, 10.4049/jimmunol.181.10.6720

RT Gazzinelli, 2006, Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism., Nat Rev Immunol, 6, 895, 10.1038/nri1978

AM Padilla, 2009, Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection., J Immunol, 183, 1245, 10.4049/jimmunol.0901178

A Cauwels, 2007, Nitric oxide in shock., Kidney Int, 72, 557, 10.1038/sj.ki.5002340

W Niedbala, 2007, Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40., Proc Natl Acad Sci U S A, 104, 15478, 10.1073/pnas.0703725104

FR Gutierrez, 2008, Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection., J Infect Dis, 197, 1468, 10.1086/587487

C Ropert, 2004, Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi., J Endotoxin Res, 10, 425, 10.1179/096805104225006507

H Cuervo, 2008, Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages., J Infect Dis, 197, 1772, 10.1086/529527

C Bogdan, 2001, Nitric oxide and the immune response., Nat Immunol, 2, 907, 10.1038/ni1001-907

A Cauwels, 2007, Survival of TNF toxicity: dependence on caspases and NO., Arch Biochem Biophys, 462, 132, 10.1016/j.abb.2007.01.021

J Bultinck, 2006, Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock., FASEB J, 20, 2363, 10.1096/fj.06-5798fje

R Singh, 2007, Regulation of hepatocyte apoptosis by oxidative stress., J Gastroenterol Hepatol, 22, S45, 10.1111/j.1440-1746.2006.04646.x

RL Conde de la, 2006, Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases., J Hepatol, 44, 918, 10.1016/j.jhep.2005.07.034

A Bafica, 2006, Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection., J Immunol, 177, 3515, 10.4049/jimmunol.177.6.3515

S Preiss, 2008, Characterization of the innate immune signalling pathways in hepatocyte cell lines., J Viral Hepat, 15, 888, 10.1111/j.1365-2893.2008.01001.x

X Zhang, 2009, Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways., Cell Microbiol, 11, 1624, 10.1111/j.1462-5822.2009.01353.x

J Wu, 2009, Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells., Hepatology, 49, 1132, 10.1002/hep.22751

FM Frank, 2003, Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes., Vaccine, 22, 77, 10.1016/S0264-410X(03)00541-3

SI Cazorla, 2008, Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model., Vaccine, 26, 1999, 10.1016/j.vaccine.2008.02.011

K Schroder, 2010, The inflammasomes., Cell, 140, 821, 10.1016/j.cell.2010.01.040