Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke
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Adibhatla, 2008, Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies, CNS Neurol. Disord. Drug Targets, 7, 243, 10.2174/187152708784936608
Agrawal, 2008, MMPs in the central nervous system: where the good guys go bad, Semin. Cell Dev. Biol., 19, 42, 10.1016/j.semcdb.2007.06.003
Alcaide, 2009, Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps, Microcirculation, 16, 43, 10.1080/10739680802273892
Amantea, 2014, Early reperfusion injury is associated to MMP2 and IL-1beta elevation in cortical neurons of rats subjected to middle cerebral artery occlusion, Neuroscience, 277, 755, 10.1016/j.neuroscience.2014.07.064
Amantea, 2008, Brain regional and cellular localization of gelatinase activity in rat that have undergone transient middle cerebral artery occlusion, Neuroscience, 152, 8, 10.1016/j.neuroscience.2007.12.030
Anthony, 1997, Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke, Neuropathol. Appl. Neurobiol., 23, 406, 10.1111/j.1365-2990.1997.tb01315.x
Asahi, 2000, Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats, J. Cereb. Blood Flow Metab., 20, 452, 10.1097/00004647-200003000-00002
Asahi, 2001a, Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia, Neuroreport, 12, 3003, 10.1097/00001756-200109170-00050
Asahi, 2001b, Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia, J. Neurosci., 21, 7724, 10.1523/JNEUROSCI.21-19-07724.2001
Bajor, 2013, Proteolytic remodeling of the synaptic cell adhesion molecules (CAMs) by metzincins in synaptic plasticity, Neurochem. Res., 38, 1113, 10.1007/s11064-012-0919-6
Bakowski, 1992, Migration of polymorphonuclear leukocytes through human amnion membrane–a scanning electron microscopic study, Biol. Chem. Hoppe Seyler, 373, 529
Bauer, 2010, Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement, J. Cereb. Blood Flow Metab., 30, 837, 10.1038/jcbfm.2009.248
Benarroch, 2007, Tissue plasminogen activator: beyond thrombolysis, Neurology, 69, 799, 10.1212/01.wnl.0000269668.08747.78
Burk, 2008, Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice, Brain Res., 1226, 248, 10.1016/j.brainres.2008.06.015
Candelario-Jalil, 2009, Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia, Neuroscience, 158, 983, 10.1016/j.neuroscience.2008.06.025
Carbone, 2015, Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways, Vascul. Pharmacol., 64, 16, 10.1016/j.vph.2014.11.007
Castellanos, 2003, Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke, Stroke, 34, 40, 10.1161/01.STR.0000046764.57344.31
Castellanos, 2007, Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study, Stroke, 38, 1855, 10.1161/STROKEAHA.106.481556
Chang, 2003, Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia, J. Cereb. Blood Flow Metab., 23, 1408, 10.1097/01.WCB.0000091765.61714.30
Chesler, 1995, Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1, Blood, 86, 4506, 10.1182/blood.V86.12.4506.bloodjournal86124506
Choi, 2009, Mechanisms of neutrophil transendothelial migration, Front. Biosci., 14, 1596, 10.2741/3327
Clark, 1997, Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia, Neurosci. Lett., 238, 53, 10.1016/S0304-3940(97)00859-8
Clark, 2008, The regulation of matrix metalloproteinases and their inhibitors, Int. J. Biochem. Cell Biol., 40, 1362, 10.1016/j.biocel.2007.12.006
Conant, 2015, Activity dependent CAM cleavage and neurotransmission, Front. Cell. Neurosci., 9, 10.3389/fncel.2015.00305
Copin, 2005, Role of matrix metalloproteinases in apoptosis after transient focal cerebral ischemia in rats and mice, Eur. J. Neurosci., 22, 1597, 10.1111/j.1460-9568.2005.04367.x
Cuadrado, 2008, Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release, J. Leukoc. Biol., 84, 207, 10.1189/jlb.0907606
Cuadrado, 2009, Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia, J. Cereb. Blood Flow Metab., 29, 398, 10.1038/jcbfm.2008.130
Cunningham, 2005, Multiple roles for MMPs and TIMPs in cerebral ischemia, Glia, 50, 329, 10.1002/glia.20169
Dejonckheere, 2011, Matrix metalloproteinases as drug targets in ischemia/reperfusion injury, Drug Discov. Today, 16, 762, 10.1016/j.drudis.2011.06.009
Fanjul-Fernández, 2010, Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models, Biochim. Biophys. Acta, 1803, 3, 10.1016/j.bbamcr.2009.07.004
Fernandez-Patron, 2001, Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32], FASEB J., 15, 2230, 10.1096/fj.01-0178com
Ferry, 1997, Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury, FEBS Lett., 402, 111, 10.1016/S0014-5793(96)01508-6
Fiorelli, 1999, Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort, Strok, 30, 2280, 10.1161/01.STR.30.11.2280
Fujimoto, 2008, Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia, J. Cereb. Blood Flow Metab., 28, 1674, 10.1038/jcbfm.2008.59
Fujimura, 1999, Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion, Brain Res., 842, 92, 10.1016/S0006-8993(99)01843-0
Fujimura, 2009, Increased expression of serum Matrix Metalloproteinase-9 in patients with moyamoya disease, Surg. Neurol., 72, 476, 10.1016/j.surneu.2008.10.009
Gasche, 2001, Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia, J. Cereb. Blood Flow Metab., 21, 1393, 10.1097/00004647-200112000-00003
Gasche, 1999, Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction, J. Cereb. Blood Flow Metab., 19, 1020, 10.1097/00004647-199909000-00010
Gasche, 2006, Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain, Front. Biosci., 11, 1289, 10.2741/1883
Gautier, 2009, Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia, Br. J. Pharmacol., 156, 673, 10.1111/j.1476-5381.2009.00068.x
Gidday, 2005, Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia, Am. J. Physiol. Heart Circ. Physiol., 289, H558, 10.1152/ajpheart.01275.2004
Golab, 2014, The rtPA increases MMP-9 activity in serum during ischaemic stroke, Neurol. Neurochir. Pol., 48, 309, 10.1016/j.pjnns.2014.07.012
Gu, 2002, S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death, Science, 297, 1186, 10.1126/science.1073634
Gurney, 2006, Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation, Neurobiol. Dis., 23, 87, 10.1016/j.nbd.2006.02.006
Gürsoy-Ozdemir, 2000, Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia, Stroke, 31, 1974, 10.1161/01.STR.31.8.1974
Hacke, 1996, ‘Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs, Arch. Neurol., 53, 309, 10.1001/archneur.1996.00550040037012
Harris, 2005, Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke, BMC Neurosci., 6, 49, 10.1186/1471-2202-6-49
Heo, 2003, Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure, Stroken, 34, e48, 10.1161/01.str.0000073788.81170.1c
Heo, 1999, Matrix metalloproteinases increase very early during experimental focal cerebral ischemia, J. Cereb. Blood Flow Metab., 19, 624, 10.1097/00004647-199906000-00005
Horstmann, 2003, Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: influence of different therapies, Stroken, 34, 2165, 10.1161/01.STR.0000088062.86084.F2
Hu, 2009, Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model, Exp. Neurol., 216, 35, 10.1016/j.expneurol.2008.11.007
Inzitari, 2013, MMP9 variation after thrombolysis is associated with hemorrhagic transformation of lesion and death, Stroke, 44, 2901, 10.1161/STROKEAHA.113.002274
Jickling, 2014, Hemorrhagic transformation after ischemic stroke in animals and humans, J. Cereb. Blood Flow Metab., 34, 185, 10.1038/jcbfm.2013.203
Justicia, 2003, Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats, J. Cereb. Blood Flow Metab., 23, 1430, 10.1097/01.WCB.0000090680.07515.C8
Keck, 2002, Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat, Gastroenterology, 122, 188, 10.1053/gast.2002.30348
Kelly, 2006, Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis, Exp. Neurol., 200, 38, 10.1016/j.expneurol.2006.01.032
Khandoga, 2006, Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver, J. Leukoc. Biol., 79, 1295, 10.1189/jlb.0805468
Kim, 2005, Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia, J. Neurosci., 25, 3701, 10.1523/JNEUROSCI.4346-04.2005
Kuroiwa, 1985, Role of extracellular proteins in the dynamics of vasogenic brain edema, Acta Neuropathol., 66, 3, 10.1007/BF00698288
Kurzepa, 2006, Simvastatin could prevent increase of the serum MMP-9/TIMP-1 ratio in acute ischaemic stroke, Folia Biol., 52, 181
Lapchak, 2000, Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke, Stroke, 31, 3034, 10.1161/01.STR.31.12.3034
Lee, 2003, Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma, J. Allergy Clin. Immunol., 111, 1278, 10.1067/mai.2003.1501
Lenglet, 2015, Role of matrix metalloproteinases in animal models of ischemic stroke, Curr. Vasc. Pharmacol., 13, 161, 10.2174/15701611113116660161
Lenglet, 2014, Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke, Thromb. Haemost., 112, 363, 10.1160/TH14-01-0007
Li, 2013, The roles of MMP-9/TIMP-1 in cerebral edema following experimental acute cerebral infarction in rats, Neurosci. Lett., 550, 168, 10.1016/j.neulet.2013.06.034
Lucivero, 2007, Different roles of matrix metalloproteinases-2 and -9 after human ischaemic stroke, Neurol. Sci., 28, 165, 10.1007/s10072-007-0814-0
Lukes, 1999, Extracellular matrix degradation by metalloproteinases and central nervous system diseases, Mol. Neurobiol., 19, 267, 10.1007/BF02821717
Lynch, 2004, Novel diagnostic test for acute stroke, Stroke, 35, 57, 10.1161/01.STR.0000105927.62344.4C
Machado, 2009, Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential, Stroke, 40, 3028, 10.1161/STROKEAHA.109.556852
Maier, 2004, Matrix metalloproteinase-9 and myeloperoxidase expression: quantitative analysis by antigen immunohistochemistry in a model of transient focal cerebral ischemia, Stroke, 35, 1169, 10.1161/01.STR.0000125861.55804.f2
Manabe, 2005, Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death, Invest. Ophthalmol. Vis. Sci., 46, 4747, 10.1167/iovs.05-0128
McCarthy, 2008, Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch, Biochemistry, 47, 5832, 10.1021/bi702496v
Moldes, 2008, High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA, Stroke, 39, 2006, 10.1161/STROKEAHA.107.495044
Montaner, 2001a, [Correlation between the expression of proinflammatory cytokines and matrix metalloproteinases in the acute phase of an ischemic stroke], Rev. Neurol., 33, 115
Montaner, 2001b, Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment, Stroke, 32, 1759, 10.1161/01.STR.32.8.1759
Montaner, 2001c, Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke, Stroke, 32, 2762, 10.1161/hs1201.99512
Montaner, 2003a, Safety profile of tissue plasminogen activator treatment among stroke patients carrying a common polymorphism (C-1562T) in the promoter region of the matrix metalloproteinase-9 gene, Stroke, 34, 2851, 10.1161/01.STR.0000098648.54429.1C
Montaner, 2003b, Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke, Circulation, 107, 598, 10.1161/01.CIR.0000046451.38849.90
Montaner, 2008, Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers, Stroken, 39, 2280, 10.1161/STROKEAHA.107.505354
Mun-Bryce, 1998, Matrix metalloproteinases in cerebrovascular disease, J. Cereb. Blood Flow Metab., 18, 1163, 10.1097/00004647-199811000-00001
Murata, 2008, Extension of the thrombolytic time window with minocycline in experimental stroke, Stroke, 39, 3372, 10.1161/STROKEAHA.108.514026
Nguyen, 2007, Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha, J. Neurochem., 102, 900, 10.1111/j.1471-4159.2007.04643.x
Ning, 2006, Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke, Neurology, 66, 1550, 10.1212/01.wnl.0000216133.98416.b4
Oda, 1995, Inhibition of neutrophil migration by a selective inhibitor of matrix metalloproteinase: analysis by intravital microscopy, Mediators Inflamm., 4, 133, 10.1155/S0962935195000238
Opdenakker, 2001, Gelatinase B functions as regulator and effector in leukocyte biology, J. Leukoc. Biol., 69, 851, 10.1189/jlb.69.6.851
Orbe, 2011, Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism, Circulation, 124, 2909, 10.1161/CIRCULATIONAHA.111.047100
Piccardi, 2015, Unbalanced metalloproteinase-9 and tissue inhibitors of metalloproteinases ratios predict hemorrhagic transformation of lesion in ischemic stroke patients treated with thrombolysis: results from the MAGIC study, Front. Neurol., 6, 10.3389/fneur.2015.00121
Planas, 2001, Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia, Neurobiol. Dis., 8, 834, 10.1006/nbdi.2001.0435
Ra, 2007, Control of matrix metalloproteinase catalytic activity, Matrix Biol., 26, 587, 10.1016/j.matbio.2007.07.001
Ramos-Fernandez, 2011, Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review, J. Stroke Cerebrovasc. Dis., 20, 47, 10.1016/j.jstrokecerebrovasdis.2009.10.008
Ranasinghe, 2012, Inhibition of MMP-9 activity following hypoxic ischemia in the developing brain using a highly specific inhibitor, Dev. Neurosci., 34, 417, 10.1159/000343257
Rivera, 2002, Gelatinase, B., and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia, Eur. J. Neurosci., 15, 19, 10.1046/j.0953-816x.2001.01838.x
Rodríguez, 2013, proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke, J. Thromb. Haemost., 11, 1464, 10.1111/jth.12312
Rodrigues, 2015, Blood cells and endothelial barrier function, Tissue Barriers, 3, e978720, 10.4161/21688370.2014.978720
Rodríguez-Yáñez, 2006, New-onset hypertension and inflammatory response/poor outcome in acute ischemic stroke, Neurology, 67, 1973, 10.1212/01.wnl.0000247064.53130.91
Romanic, 1998, Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size, Stroke, 29, 1020, 10.1161/01.STR.29.5.1020
Rosell, 2005, A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke, Stroke, 36, 1415, 10.1161/01.STR.0000170641.01047.cc
Rosell, 2008, MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke, Stroke, 39, 1121, 10.1161/STROKEAHA.107.500868
Rosell, 2006, Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke, Stroke, 37, 1399, 10.1161/01.STR.0000223001.06264.af
Rosenberg, 2001, Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures, Brain Res., 893, 104, 10.1016/S0006-8993(00)03294-7
Rosenberg, 1998, Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain, Stroke, 29, 2189, 10.1161/01.STR.29.10.2189
Rosenberg, 2007, Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia, Neurosurg. Focus, 22, E4, 10.3171/foc.2007.22.5.5
Sandoval, 2008, Blood-brain barrier tight junction permeability and ischemic stroke, Neurobiol. Dis., 32, 200, 10.1016/j.nbd.2008.08.005
Schnoor, 2008, Disassembly of endothelial and epithelial junctions during leukocyte transmigration, Front. Biosci., 13, 6638, 10.2741/3178
Shigemori, 2006, Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats, Acta Neurochir. Suppl., 96, 130, 10.1007/3-211-30714-1_29
Si-Tayeb, 2006, Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis, Am. J. Pathol., 169, 1390, 10.2353/ajpath.2006.060005
Sotgiu, 2006, Inflammatory biomarkers in blood of patients with acute brain ischemia, Eur. J. Neurol., 13, 505, 10.1111/j.1468-1331.2006.01280.x
Steadman, 1997, Human neutrophils do not degrade major basement membrane components during chemotactic migration, Int. J. Biochem. Cell Biol., 29, 993, 10.1016/S1357-2725(97)00038-1
Sternlicht, 2001, How matrix metalloproteinases regulate cell behavior, Annu. Rev. Cell Dev. Biol., 17, 463, 10.1146/annurev.cellbio.17.1.463
Sumii, 2002, Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats, Stroke, 33, 831, 10.1161/hs0302.104542
Svedin, 2007, Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia, J. Neurosci., 27, 1511, 10.1523/JNEUROSCI.4391-06.2007
Tan, 2003, Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons, Mol. Cell. Neurosci., 22, 98, 10.1016/S1044-7431(02)00024-6
Tang, 2006, Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study, J. Cereb. Blood Flow Metab., 26, 1089, 10.1038/sj.jcbfm.9600264
Tsuji, 2005, Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia, Stroke, 36, 1954, 10.1161/01.STR.0000177517.01203.eb
Tsuruoka, 2014, Effects of edaravone, a free radical scavenger, on circulating levels of MMP-9 and hemorrhagic transformation in patients with intravenous thrombolysis using low-dose alteplase, J. Stroke Cerebrovasc. Dis., 23, 2894, 10.1016/j.jstrokecerebrovasdis.2014.07.022
Turba, 2007, Recruited leukocytes and local synthesis account for increased matrix metalloproteinase-9 activity in cerebrospinal fluid of dogs with central nervous system neoplasm, J. Neurooncol., 81, 123, 10.1007/s11060-006-9213-2
Van den Steen, 2002, Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9), Crit. Rev. Biochem. Mol. Biol., 37, 375, 10.1080/10409230290771546
Vandooren, 2013, Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade, Crit. Rev. Biochem. Mol. Biol., 48, 222, 10.3109/10409238.2013.770819
Vukasovic, 2006, Matrix metalloproteinases and their inhibitors in different acute stroke subtypes, Clin. Chem. Lab. Med., 44, 428, 10.1515/cclm.2006.079
Wang, 2009, Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats, J. Cereb. Blood Flow Metab., 29, 1683, 10.1038/jcbfm.2009.87
Wang, 2002, The signaling pathways induced by neutrophil-endothelial cell adhesion, Antioxid. Redox Signal., 4, 39, 10.1089/152308602753625843
Wang, 2003, Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator, Nat. Med., 9, 1313, 10.1038/nm926
Yan, 2007, Regulation of matrix metalloproteinase gene expression, J. Cell. Physiol., 211, 19, 10.1002/jcp.20948
Yang, 2007, Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat, J. Cereb. Blood Flow Metab., 27, 697, 10.1515/CCLM.2006.079
Yang, 2011, Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-alpha/TACE in focal cerebral ischemia in mice, J. Neuroinflammation, 8, 108, 10.1186/1742-2094-8-108
Yushchenko, 2000, Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count, J. Neuroimmunol., 110, 244, 10.1016/S0165-5728(00)00339-8
Zhao, 2007, Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke, Stroke, 38, 748, 10.1161/01.STR.0000253500.32979.d1
Zhao, 2006, Role of matrix metalloproteinases in delayed cortical responses after stroke, Nat. Med., 12, 441, 10.1038/nm1387
Zhao, 2013, Effect of focal mild hypothermia on expression of MMP-9, TIMP-1, Tau-1 and beta-APP in rats with cerebral ischaemia/reperfusion injury, Brain Inj., 27, 1190, 10.3109/02699052.2013.804206