Implementing living‐donor pediatric liver transplantation in Southern Vietnam: 15‐year results and perspectives

Pediatric Transplantation - Tập 28 Số 1 - 2024
Tran Thanh Tri1, Ho Phi Duy1, Nguyễn An Thuận Lưu1, Thi Yen Nhi Truong1, Hong Van Khanh Nguyen1, Hai Trung Bui1, Ngoc Thach Pham2, Dong A. Tran2, Thierry Pirotte3, Michael Gurevich4, Raymond Reding5
1Department of Hepato-Pancreato-Biliary Diseases and Liver Transplant, Children's Hospital 2, Ho Chi Minh City, Vietnam
2Children's Hospital 2, Ho Chi Minh City, Vietnam
3Department of Anesthesiology, Cliniques universitaires Saint-Luc, Brussels, Belgium
4Department of Surgery, Schneider's Children Hospital, Petah Tikva, Israel
5Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Brussels, Belgium

Tóm tắt

AbstractBackgroundND2 in Ho Chi Minh City is currently the only public center that performs PLT in Southern Vietnam. In 2005, the first PLT was successfully performed, with support from Belgian experts. This study reviews the implementation of PLT at our center and evaluates the results and challenges.MethodsImplementation of PLT at ND2 required medico‐surgical team building and extensive improvement of hospital facilities. Records of 13 transplant recipients from 2005 to 2020 were studied retrospectively. Short‐ and long‐term complications, as well as the survival rates, were reported.ResultsThe mean follow‐up time was 8.3 ± 5.7 years. Surgical complications included one case of hepatic artery thrombosis that was successfully repaired, one case of colon perforation resulting in death from sepsis, and two cases of bile leak that were drained surgically. PTLD was observed in five patients, of whom three died. There were no cases of retransplantation. The 1‐year, 5‐year, and 10‐year patient survival rates were 84.6%, 69.2%, and 69.2%, respectively. There were no cases of complication or death among the donors.ConclusionLiving‐donor PLT was developed at ND2 for providing a life‐saving treatment to children with end‐stage liver disease. Early surgical complication rate was low, and the patient survival rate was satisfactory at 1 year. Long‐term survival decreased considerably due to PTLD. Future challenges include surgical autonomy and improvement of long‐term medical follow‐up with a particular emphasis on prevention and management of Epstein–Barr virus‐related disease.

Từ khóa


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Pediatric Transplantation

Tập 28 Số 1

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