Implementation of tuberculosis infection control in health facilities in Mukono and Wakiso districts, Uganda

BMC Infectious Diseases - Tập 13 - Trang 1-9 - 2013
Esther Buregyeya1, Fred Nuwaha1, Suzanne Verver2, Bart Criel3, Robert Colebunders3,4, Rhoda Wanyenze1, Joan N Kalyango5, Achilles Katamba5, Ellen MH Mitchell2
1Makerere University College of Health Sciences School of Public Health, Kampala, Uganda
2KNCV Tuberculosis Foundation, The Hague, The Netherlands
3Institute of Tropical Medicine, Antwerp, Belgium
4University of Antwerp, Antwerp, Belgium
5Clinical Epidemiology Unit, College of Health Sciences Makerere University, Kampala, Uganda

Tóm tắt

Tuberculosis infection control (TBIC) is rarely implemented in the health facilities in resource limited settings. Understanding the reasons for low level of implementation is critical. The study aim was to assess TBIC practices and barriers to implementation in two districts in Uganda. We conducted a cross-sectional study in 51 health facilities in districts of Mukono and Wakiso. The study included: a facility survey, observations of practices and eight focus group discussions with health workers. Quantitative: Only 16 facilities (31%) had a TBIC plan. Five facilities (10%) were screening patients for cough. Two facilities (4%) reported providing masks to patients with cough. Ventilation in the waiting areas was inadequate for TBIC in 43% (22/51) of the facilities. No facility possessed N95 particulate respirators. Qualitative: Barriers that hamper implementation of TBIC elicited included: under-staffing, lack of space for patient separation, lack of funds to purchase masks, and health workers not appreciating the importance of TBIC. TBIC measures were not implemented in health facilities in the two Ugandan districts where the survey was done. Health system factors like lack of staff, space and funds are barriers to implement TBIC. Effective implementation of TBIC measures occurs when the fundamental health system building blocks -governance and stewardship, financing, infrastructure, procurement and supply chain management are in place and functioning appropriately.

Tài liệu tham khảo

WHO: WHO policy on TB infection control in health-care facilities, congregate settings and households. 2009, Geneva: World Health Organization, 11-15. Bucher HC, Griffith LE, Guyatt GH, Sudre P, Naef M, et al: Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. AIDS. 1999, 13: 501-507. 10.1097/00002030-199903110-00009. Daley CL, Small PM, Schecter GF: An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus: an analysis using restriction-fragment-length polymorphisms. N Engl J Med. 1992, 326: 231-251. 10.1056/NEJM199201233260404. Shafer RW, Singh SP, Larkin C, Small PM: Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient. Tuber Lung Dis. 1995, 76: 575-577. 10.1016/0962-8479(95)90537-5. Alonso-Echanove J, Granich RM, Laszlo A, Chu G, Borja N, et al: Occupational transmission of Mycobacterium tuberculosis to health care workers in a university hospital in Lima, Peru. Clin Infect Dis. 2001, 33: 589-596. 10.1086/321892. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al: Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006, 368: 1575-1580. 10.1016/S0140-6736(06)69573-1. Joshi R, Reingold AL, Menzies D, Pai M: Tuberculosis among health-care workers in low- and middle-income countries: A systematic review. PloS Medicine. 2006, 3: e494-10.1371/journal.pmed.0030494. Kassim S, Zuber P, Wiktor SZ, Diomande FV, Coulibaly IM, et al: Tuberculin skin testing to assess the occupational risk of Mycobacterium tuberculosis infection among health care workers in Abidjan, Cote d'Ivoire. Int J Tuberc Lung Dis. 2000, 4: 321-326. O'Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, et al: High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med. 2010, 153: 516-522. 10.7326/0003-4819-153-8-201010190-00008. WHO: Guidelines for the prevention of tuberculosis in health care facilities in resource -limited settings. 1999, Geneva: World Health Organization FMOH: Guidelines for prevention of transmission of tuberculosis in health care facilities, congregate and community settings in Ethiopia. 2009, Ethiopia: Federal Ministry of Health Menzies D, Joshi R, Pai M: Risk of tuberculosis infection and disease associated with work in health care settings. Int J Tuberc Lung Dis. 2007, 11: 593-605. Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, et al: Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection. PLoS One. 2011, 6: e16130-10.1371/journal.pone.0016130. WHO: WHO Policy on TB Infection Controlin Health-Care Facilities, Congregate Settings and Households. 2009, In: Department WST, editor Albuquerque da Costa P, Trajman A, de Queiroz C, Mello F, Goudinho S, Monteiro Vieira Silva MA, et al: Administrative measures for preventing Mycobacterium tuberculosis infection among healthcare workers in a teaching hospital in Rio de Janeiro, Brazil. J Hosp Infect. 2009, 72: 57-64. 10.1016/j.jhin.2009.01.016. Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, et al: Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012, 185: 1104-1109. 10.1164/rccm.201107-1190OC. Shenoi SV, Escombe AR, Friedland G: Transmission of drug-susceptible and drug-resistant tuberculosis and the critical importance of airborne infection control in the era of HIV infection and highly active antiretroviral therapy rollouts. Clin Infect Dis. 2010, 50 (Suppl 3): S231-S237. Jensen PA, Lambert LA, Iademarco MF, Ridzon R: Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR Recomm Rep. 2005, 54: 1-141. Jelip J, Mathew GG, Yusin T, Dony JF, Singh N, et al: Risk factors of tuberculosis among health care workers in Sabah, Malaysia. Tuberculosis (Edinb). 2004, 84: 19-23. 10.1016/j.tube.2003.08.015. Luksamijarulkul P, Supapvanit C, Loosereewanich P, Aiumlaor P: Risk assessment towards tuberculosis among hospital personnel: administrative control, risk exposure, use of protective barriers and microbial air quality. Southeast Asian J Trop Med Public Health. 2004, 35: 1005-1011. Menzies D, Fanning A, Yuan L, Fitzgerald M: Tuberculosis among health care workers. N Engl J Med. 1995, 332: 92-98. 10.1056/NEJM199501123320206. Biscotto CR, Pedroso ER, Starling CE, Roth VR: Evaluation of N95 respirator use as a tuberculosis control measure in a resource-limited setting. Int J Tuberc Lung Dis. 2005, 9: 545-549. Alvaran MS, Butz A, Larson E: Opinions, knowledge, and self-reported practices related to infection control among nursing personnel in long-term care settings. Am J Infect Control. 1994, 22: 367-370. 10.1016/0196-6553(94)90036-1. Madan AK, Raafat A, Hunt JP, Rentz D, Wahle MJ, et al: Barrier precautions in trauma: is knowledge enough?. J Trauma. 2002, 52: 540-543. 10.1097/00005373-200203000-00020. WHO: Global Tuberculosis control. 2012, World Health Organization, http://www.who.int/tb/publications/global_report/gtbr12_main.pdf, UBOS (2009/10): Uganda national household survey. Kampala. 2009, Uganda: Bureau of Statistics MOH: Uganda AIDS indicator survey 2011. 2012, Kampala: Ministry of Health Uganda Buregyeya E, Nuwaha F, Wanyenze RK, Mitchell EMH, Criel B: Utilization of HIV and Tuberculosis Services by Health Care Workers in Uganda. 2012, Uganda: Implications for Occupational Health Policies and Implementation, PloS ONE In press MOH: Uganda health sector strategic plan;. 2000, /01-2004/05 MOH: Uganda national guidelines for tuberculosis infection control in health care facilities, congregate settings and households. 2011, Kampala: Ministry of Health RHRU: Implementing TB infection control in health care facilities. 2009, Johannesburg: Reproductive Health & HIV Research Unit of the University of the Witwatersrand, South Africa Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH: Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. J Hosp Infect. 2011, 79: 333-338. 10.1016/j.jhin.2011.06.017. Ogbonnaya LU, Chukwu JN, Uwakwe KA, Oyibo PG, Ndukwe CD: The status of tuberculosis infection control measures in health care facilities rendering joint TB/HIV services in "German Leprosy and Tuberculosis Relief Association" supported states in Nigeria. Niger J Clin Pract. 2011, 14: 270-275. 10.4103/1119-3077.86765. Adams AS, Soumerai SB, Lomas J, Ross-Degnan D: Evidence of self-report bias in assessing adherence to guidelines. Int J Qual Health Care. 1999, 11: 187-192. 10.1093/intqhc/11.3.187. Naikoba S, Hayward A: The effectiveness of interventions aimed at increasing handwashing in healthcare workers - a systematic review. J Hosp Infect. 2001, 47: 173-180. 10.1053/jhin.2000.0882. WHO: Everybody business: strengthening health systems to improve health outcomes: WHO’s framework for action. 2007, Geneva: World Health Organization Pittet D, Simon A, Hugonnet S, Pessoa-Silva CL, Sauvan V, et al: Hand hygiene among physicians: performance, beliefs, and perceptions. Ann Intern Med. 2004, 141: 1-8. 10.7326/0003-4819-141-1-200407060-00008. Woith W, Volchenkov G, Larson J: Barriers and motivators affecting tuberculosis infection control practices of Russian health care workers. Int J Tuberc Lung Dis. 2012, 16: 1092-1096. 10.5588/ijtld.10.0779. Robins CS, Ware NC, dosReis S, Willging CE, Chung JY, et al: Dialogues on mixed-methods and mental health services research: anticipating challenges, building solutions. Psychiatr Serv. 2008, 59: 727-731. 10.1176/appi.ps.59.7.727. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/360/prepub