Implant Surface Characteristics Modulate Differentiation Behavior of Cells in the Osteoblastic Lineage

Advances in dental research - Tập 13 Số 1 - Trang 38-48 - 1999
Zvi Schwartz1, Christoph H. Lohmann2, J. Oefinger3, Lynda F. Bonewald4, David D. Dean3, Barbara D. Boyan3
1Department of Orthopaedics, Hebrew University Jerusalem, Israel
2Department of Orthopaedics, University of Gottingen, Germany
3Department of Orthopaedics,
4Department of Medicine/Endocrinology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio, Texas 78284-7774, USA

Tóm tắt

This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-β1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

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Advances in dental research

Tập 13 Số 1

38-48

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