Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

Amin-Hanjani, 2015, Effect of age and vascular anatomy on blood flow in major cerebral vessels, J. Cereb. Blood Flow Metab., 35, 312, 10.1038/jcbfm.2014.203

Bailey-Downs, 2012, Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging, J. Gerontol. Biol. Med. Sci., 67, 313, 10.1093/gerona/glr164

Balbi, 2015, Dysfunction of mouse cerebral arteries during early aging, J. Cereb. Blood Flow Metab., 35, 1445, 10.1038/jcbfm.2015.107

Bhat, 2012, Astrocyte senescence as a component of Alzheimer's disease, PLoS One, 7, 10.1371/journal.pone.0045069

Blanco, 2008, Tone-dependent vascular responses to astrocyte-derived signals, Am. J. Physiol. Heart Circ. Physiol., 294, H2855, 10.1152/ajpheart.91451.2007

Bonder, 2014, Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo, J. Neurosci., 34, 13139, 10.1523/JNEUROSCI.2591-14.2014

Bruhn, 2001, Modulation of cerebral blood oxygenation by indomethacin: MRI at rest and functional brain activation, J. Magn. Reson. Imaging, 13, 325, 10.1002/jmri.1047

Chen, 2014, A critical role for the vascular endothelium in functional neurovascular coupling in the brain, J. Am. Heart Assoc., 3, 10.1161/JAHA.114.000787

Corriveau, 2016, The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): a framework for advancing research priorities in the cerebrovascular biology of cognitive decline, Cell. Mol. Neurobiol., 36, 281, 10.1007/s10571-016-0334-7

Csiszar, 2002, Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function, Circ. Res., 90, 1159, 10.1161/01.RES.0000020401.61826.EA

Csiszar, 2008, Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice, Am. J. Physiol. Heart Circ. Physiol., 295, H1882, 10.1152/ajpheart.412.2008

Drew, 2010, Chronic optical access through a polished and reinforced thinned skull, Nat. Methods, 7, 981, 10.1038/nmeth.1530

Enager, 2009, Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex, J. Cereb. Blood Flow Metab., 29, 976, 10.1038/jcbfm.2009.23

Fabiani, 2013, Neurovascular coupling in normal aging: a combined optical, ERP and fMRI study, NeuroImage

Farkas, 2014, Spreading depolarization in the ischemic brain: does aging have an impact?, J. Gerontol. A Biol. Sci. Med. Sci., 69, 1363, 10.1093/gerona/glu066

Fernandes, 2008, IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid, J. Cell Biol., 181, 143, 10.1083/jcb.200712058

Girouard, 2007, Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II, Arterioscler. Thromb. Vasc. Biol., 27, 303, 10.1161/01.ATV.0000253885.41509.25

Gordon, 2008, Brain metabolism dictates the polarity of astrocyte control over arterioles, Nature, 456, 745, 10.1038/nature07525

Gorelick, 2011, Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association, Stroke, 42, 2672, 10.1161/STR.0b013e3182299496

Hartings, 2016, The continuum of spreading depolarizations in acute cortical lesion development: examining Leao's legacy, J. Cereb. Blood Flow Metab.

Hock, 1997, Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)—correlation with simultaneous rCBF-PET measurements, Brain Res., 755, 293, 10.1016/S0006-8993(97)00122-4

Iadecola, 2013, The pathobiology of vascular dementia, Neuron, 80, 844, 10.1016/j.neuron.2013.10.008

Iadecola, 2008, Hypertension and cerebrovascular dysfunction, Cell Metab., 7, 476, 10.1016/j.cmet.2008.03.010

Iadecola, 2009, Threats to the mind: aging, amyloid, and hypertension, Stroke, 40, S40, 10.1161/STROKEAHA.108.533638

Jessen, 2015, Interneuron deficit associates attenuated network synchronization to mismatch of energy supply and demand in aging mouse brains, Cereb. Cortex

Keleshian, 2013, Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex, J. Neurochem., 125, 63, 10.1111/jnc.12153

Kur, 2014, Purinergic control of vascular tone in the retina, J. Physiol., 592, 491, 10.1113/jphysiol.2013.267294

Lind, 2013, Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo, Proc. Natl. Acad. Sci. U. S. A., 110, E4678, 10.1073/pnas.1310065110

Liu, 2012, Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice, Life Sci., 91, 872, 10.1016/j.lfs.2012.08.033

Mathiesen, 1998, Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex, J. Physiol., 512, 555, 10.1111/j.1469-7793.1998.555be.x

Mathiesen, 2013, Spontaneous calcium waves in Bergman glia increase with age and hypoxia and may reduce tissue oxygen, J. Cereb. Blood Flow Metab., 33, 161, 10.1038/jcbfm.2012.175

Menyhart, 2015, High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain, Neurobiol. Aging, 36, 3269, 10.1016/j.neurobiolaging.2015.08.014

Metea, 2006, Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling, J. Neurosci., 26, 2862, 10.1523/JNEUROSCI.4048-05.2006

Nicolakakis, 2008, Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, J. Neurosci., 28, 9287, 10.1523/JNEUROSCI.3348-08.2008

Nilius, 2003, The TRPV4 channel: structure-function relationship and promiscuous gating behaviour, Pflugers Arch., 446, 298, 10.1007/s00424-003-1028-9

Nizar, 2013, In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase, J. Neurosci., 33, 8411, 10.1523/JNEUROSCI.3285-12.2013

Oomen, 2009, Resveratrol preserves cerebrovascular density and cognitive function in aging mice, Front. Aging Neurosci., 1, 4, 10.3389/neuro.24.004.2009

Otsu, 2015, Calcium dynamics in astrocyte processes during neurovascular coupling, Nat. Neurosci., 18, 210, 10.1038/nn.3906

Pardo, 2016, Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats, Eur. J. Neurosci., 44, 2120, 10.1111/ejn.13278

Park, 2005, NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide, J. Neurosci., 25, 1769, 10.1523/JNEUROSCI.5207-04.2005

Park, 2007, Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain, J. Cereb. Blood Flow Metab., 27, 1908, 10.1038/sj.jcbfm.9600491

Park, 2008, Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein, Proc. Natl. Acad. Sci. U. S. A., 105, 1347, 10.1073/pnas.0711568105

Petzold, 2011, Role of astrocytes in neurovascular coupling, Neuron, 71, 782, 10.1016/j.neuron.2011.08.009

Rombouts, 2000, Functional MR imaging in Alzheimer's disease during memory encoding, AJNR Am. J. Neuroradiol., 21, 1869

Rosenegger, 2015, Tonic local brain blood flow control by astrocytes independent of phasic neurovascular coupling, J. Neurosci., 35, 13463, 10.1523/JNEUROSCI.1780-15.2015

Shin, 2007, Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy, Brain, 130, 2310, 10.1093/brain/awm156

Snyder, 2015, Vascular contributions to cognitive impairment and dementia including Alzheimer's disease, Alzheimers Dement., 11, 710, 10.1016/j.jalz.2014.10.008

Snyder, 2015, Vascular contributions to cognitive impairment and dementia including Alzheimer's disease, Alzheimers Dement., 11, 710, 10.1016/j.jalz.2014.10.008

Sonntag, 2013, Insulin-like growth factor-1 in CNS and cerebrovascular aging, Front. Aging Neurosci., 5, 27, 10.3389/fnagi.2013.00027

Sorond, 2008, Cerebral blood flow regulation during cognitive tasks: effects of healthy aging, Cortex, 44, 179, 10.1016/j.cortex.2006.01.003

Sorond, 2010, Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston Study, Neurology, 74, 1627, 10.1212/WNL.0b013e3181df0982

Sorond, 2011, Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study, Ann. Neurol., 70, 213, 10.1002/ana.22433

Sorond, 2013, Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people, Neurology, 10.1212/WNL.0b013e3182a351aa

Stefanova, 2013, Age-related changes of blood-oxygen-level-dependent signal dynamics during optokinetic stimulation, Neurobiol. Aging, 34, 2277, 10.1016/j.neurobiolaging.2013.03.031

Stobart, 2013, Astrocyte-induced cortical vasodilation is mediated by d-serine and endothelial nitric oxide synthase, Proc. Natl. Acad. Sci. U. S. A., 110, 3149, 10.1073/pnas.1215929110

Szabo, 2014, Effect of non-steroid anti-inflammatory drugs on neurovascular coupling in humans, J. Neurol. Sci., 336, 227, 10.1016/j.jns.2013.10.048

Takata, 2013, Cerebral blood flow modulation by basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes, PLoS One, 8, 10.1371/journal.pone.0066525

Tarantini, 2015, Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice, J. Cereb. Blood Flow Metab., 35, 1871, 10.1038/jcbfm.2015.162

Tong, 2012, Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits, J. Neurosci., 32, 4705, 10.1523/JNEUROSCI.0169-12.2012

Topcuoglu, 2009, Occipital cortex activation studied with simultaneous recordings of functional transcranial Doppler ultrasound (fTCD) and visual evoked potential (VEP) in cognitively normal human subjects: effect of healthy aging, Neurosci. Lett., 452, 17, 10.1016/j.neulet.2009.01.030

Toth, 2014, Resveratrol treatment rescues neurovascular coupling in aged mice:role of improved cerebromicrovascular endothelial function and down-regulation of NADPH oxidas, Am. J. Physiol. Heart Circ. Physiol., 306, H299, 10.1152/ajpheart.00744.2013

Toth, 2015, IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging, Aging Cell, 14, 1034, 10.1111/acel.12372

Toth, 2015, Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex, Am. J. Physiol. Heart Circ. Physiol., 309, H1837, 10.1152/ajpheart.00463.2015

Tran, 2015, Acute two-photon imaging of the neurovascular unit in the cortex of active mice, Front. Cell. Neurosci., 9, 11, 10.3389/fncel.2015.00011

Tran, 2015, Astrocyte and microvascular imaging in awake animals using two-photon microscopy, Microcirculation, 22, 219, 10.1111/micc.12188

Tucsek, 2014, Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice, J. Gerontol. A Biol. Sci. Med. Sci., 69, 1339, 10.1093/gerona/glu080

Ungvari, 2012, The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances, J. Gerontol. A Biol. Sci. Med. Sci., 67, 599, 10.1093/gerona/gls072

Ungvari, 2010, Mechanisms of vascular aging: new perspectives, J. Gerontol. A Biol. Sci. Med. Sci., 65, 1028, 10.1093/gerona/glq113

Wells, 2015, A critical role for purinergic signalling in the mechanisms underlying generation of BOLD fMRI responses, J. Neurosci., 35, 5284, 10.1523/JNEUROSCI.3787-14.2015

Zaletel, 2005, Age-related changes in the relationship between visual evoked potentials and visually evoked cerebral blood flow velocity response, Funct. Neurol., 20, 115

Zhao, 2013, Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway, Biochem. Biophys. Res. Commun., 435, 597, 10.1016/j.bbrc.2013.05.025

Zonta, 2003, Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation, Nat. Neurosci., 6, 43, 10.1038/nn980