Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis

Aslan, 2013, A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies, J. Infect. Dis., 207, 1328, 10.1093/infdis/jis932 Cojean, 2012, Leishmania resistance to miltefosine associated with genetic marker, Emerg. Infect. Dis., 18, 704, 10.3201/eid1804.110841 Dorlo, 2012, Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis, J. Antimicrob. Chemother., 67, 2576, 10.1093/jac/dks275 Dvorak, 2018, Parasite biology: the vectors, 31 Eberhardt, 2019, Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain, J Antimicrob. Chemother., 74, 395, 10.1093/jac/dky450 Fernandez-Prada, 2016, Different mutations in a P-type ATPase transporter in Leishmania parasites are associated with cross-resistance to two leading drugs by distinct mechanisms, PLoS Neglected Trop. Dis., 10, 10.1371/journal.pntd.0005171 Garcia-Sanchez, 2014, Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit, Biochem. J., 459, 83, 10.1042/BJ20131318 Hendrickx, 2016, Evidence of a drug-specific impact of experimentally selected paromomycin and miltefosine resistance on parasite fitness in Leishmania infantum, J. Antimicrob. Chemother., 71, 1914, 10.1093/jac/dkw096 Hendrickx, 2014, Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum, Parasitol. Res., 113, 1875, 10.1007/s00436-014-3835-7 Hendrickx, 2015, Intracellular amastigote replication may not be required for successful in vitro selection of miltefosine resistance in Leishmania infantum, Parasitol. Res., 114, 2561, 10.1007/s00436-015-4460-9 Kamhawi, 2006, Phlebotomine sand flies and Leishmania parasites: friends or foes?, Trends Parasitol., 22, 439, 10.1016/j.pt.2006.06.012 Mondelaers, 2016, Genomic and molecular characterization of miltefosine resistance in Leishmania infantum strains with either natural or acquired resistance through experimental selection of intracellular amastigotes, PLoS One, 11, 10.1371/journal.pone.0154101 Pandey, 2016, Pharmacovigilance of miltefosine in treatment of visceral leishmaniasis in endemic areas of Bihar, India, Am. J. Trop. Med. Hyg., 95, 1100, 10.4269/ajtmh.16-0242 Perez-Victoria, 2006, Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites, J. Biol. Chem., 281, 23766, 10.1074/jbc.M605214200 Perez-Victoria, 2006, Mechanisms of experimental resistance of Leishmania to miltefosine: implications for clinical use, Drug Resist. Updates, 9, 26, 10.1016/j.drup.2006.04.001 Rakotomanga, 2005, Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions, Antimicrob. Agents Chemother., 49, 2677, 10.1128/AAC.49.7.2677-2686.2005 Ready, 2014, Epidemiology of visceral leishmaniasis, Clin. Epidemiol., 6, 147, 10.2147/CLEP.S44267 Rijal, 2013, Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance, Clin. Infect. Dis., 56, 1530, 10.1093/cid/cit102 Rogers, 2007, Leishmania manipulation of sand fly feeding behavior results in enhanced transmission, PLoS Pathog., 3, 10.1371/journal.ppat.0030091 Rogers, 2008, Leishmania chitinase facilitates colonization of sand fly vectors and enhances transmission to mice, Cell Microbiol., 10, 1363, 10.1111/j.1462-5822.2008.01132.x Sacks, 2001, Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis, Annu. Rev. Microbiol., 55, 453, 10.1146/annurev.micro.55.1.453 Schneider, 2012, NIH Image to ImageJ: 25 years of Image Analysis, Nat Methods, 9, 671, 10.1038/nmeth.2089 Secundino, 2012, The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates, Parasites Vectors, 5, 20, 10.1186/1756-3305-5-20 Serafim, 2018, Sequential blood meals promote Leishmania replication and reverse metacyclogenesis augmenting vector infectivity, Nat Microbiol, 3, 548, 10.1038/s41564-018-0125-7 Srivastava, 2017, Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from India, Parasites Vectors, 10, 49, 10.1186/s13071-017-1969-z Sundar, 2012, Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use, Clin. Infect. Dis., 55, 543, 10.1093/cid/cis474 Vermeersch, 2009, In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences, Antimicrob. Agents Chemother., 53, 3855, 10.1128/AAC.00548-09 Volf, 2004, Blocked stomodeal valve of the insect vector: similar mechanism of transmission in two trypanosomatid models, Int. J. Parasitol., 34, 1221, 10.1016/j.ijpara.2004.07.010 Volf, 2011, Establishment and maintenance of sand fly colonies, J. Vector Ecol., 36, S1, 10.1111/j.1948-7134.2011.00106.x Zakai, 1998, In vitro stimulation of metacyclogenesis in Leishmania braziliensis, L. donovani, L. major and L. mexicana, Parasitology, 116, 305, 10.1017/S0031182097002382