Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue

Aging - Tập 8 Số 10 - Trang 2525-2537 - 2016
Amiya K. Ghosh1, Theresa Mau1, Martin O’Brien1, Sanjay Garg1, Raymond Yung1,2
1Division of Geriatric- and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
2Geriatric Research, Education and Clinical Care Center (GRECC), VA Ann Arbor Health System, University of Michigan, Ann Arbor, MI 48109, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Caruso, 2007, Inflammatory networks in ageing, age-related diseases and longevity., Mech Ageing Dev, 12, 83, 10.1016/j.mad.2006.11.015

Hasty, 2012, Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion., PLoS One, 7, e31508, 10.1371/journal.pone.0031508

Meydani, 2007, Aging up-regulates expression of inflammatory mediators in mouse adipose tissue., J Immunol, 17, 4829, 10.4049/jimmunol.179.7.4829

Yung, 2011, Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue., J Immunol, 18, 6208, 10.4049/jimmunol.1102188

Poehlman, 2001, Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women., Diabetes Care, 2, 925, 10.2337/diacare.24.5.925

Ferrucci, 2010, Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study., J Gerontol A Biol Sci Med Sci, 6, 84, 10.1093/gerona/glp150

Tichansky, 2010, Dexamethasone and the inflammatory response in explants of human omental adipose tissue., Mol Cell Endocrinol, 31, 292, 10.1016/j.mce.2009.10.004

Ferrante, 2003, Obesity is associated with macrophage accumulation in adipose tissue., J Clin Invest, 11, 1796, 10.1172/JCI200319246

Kirkland, 2010, Aging, depot origin, and preadipocyte gene expression., J Gerontol A Biol Sci Med Sci, 6, 242, 10.1093/gerona/glp213

MacDougald, 2012, Adipose tissue stem cells meet preadipocyte commitment: going back to the future., J Lipid Res, 5, 227, 10.1194/jlr.R021089

Yung, 2015, Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging., J Gerontol A Biol Sci Med Sci, 7, 1320

Li, 2015, Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes., Gen Comp Endocrinol, 21, 124, 10.1016/j.ygcen.2014.09.006

Blumberg, 2015, Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease., Curr Opin Gastroenterol, 3, 81, 10.1097/MOG.0000000000000144

Klionsky, 2009, Regulation mechanisms and signaling pathways of autophagy., Annu Rev Genet, 4, 67, 10.1146/annurev-genet-102808-114910

Hotamisligil, 2010, Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance., Cell Metab, 1, 467, 10.1016/j.cmet.2010.04.005

Paolisso, 2004, Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly., J Am Geriatr Soc, 5, 399, 10.1111/j.1532-5415.2004.52112.x

Ferrucci, 2004, Insulin resistance and executive dysfunction in older persons., J Am Geriatr Soc, 5, 1713, 10.1111/j.1532-5415.2004.52466.x

Boscá, 2014, Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD., Cell Death Dis, 5, e1179, 10.1038/cddis.2014.162

Sandri, 2010, Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles., Autophagy, 6, 307, 10.4161/auto.6.2.11137

Abeliovich, 2012, Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway., Mol Neurodegener, 7, 48, 10.1186/1750-1326-7-48

Wyttenbach, 2009, mTOR’s role in ageing: protein synthesis or autophagy?, Aging (Albany NY), 1, 586, 10.18632/aging.100070

Kroemer, 2009, Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol., Aging (Albany NY), 1, 961, 10.18632/aging.100110

Rabinovitch, 2016, Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts., Aging (Albany NY), 8, 314, 10.18632/aging.100881

Gillon, 1994, Effects of age and anatomic site on preadipocyte number in rat fat depots., J Gerontol, 4, B31, 10.1093/geronj/49.1.B31

Walford, 1988, Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice., J Gerontol, 4, B40, 10.1093/geronj/43.2.B40

Masoro, 2006, Caloric restriction and aging: controversial issues., J Gerontol A Biol Sci Med Sci, 6, 14, 10.1093/gerona/61.1.14

Kahn, 2003, Extended longevity in mice lacking the insulin receptor in adipose tissue., Science, 29, 572, 10.1126/science.1078223

Schuster, 2009, Ribosomal protein S6 kinase 1 signaling regulates mammalian life span., Science, 32, 140, 10.1126/science.1177221

Kopchick, 2008, Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models., Growth Horm IGF Res, 1, 455, 10.1016/j.ghir.2008.05.005

Mao, 2009, Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice., J Pharmacol Sci, 10, 496, 10.1254/jphs.08215FP

Miller, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice., Nature, 46, 392

Barzilai, 2008, Visceral adipose tissue modulates mammalian longevity., Aging Cell, 7, 438, 10.1111/j.1474-9726.2008.00391.x

Masternak, 2014, The contribution of visceral fat to improved insulin signaling in Ames dwarf mice., Aging Cell, 1, 497, 10.1111/acel.12201

Sinclair, 2005, Toward a unified theory of caloric restriction and longevity regulation., Mech Ageing Dev, 12, 987, 10.1016/j.mad.2005.03.019

Anderson, 2014, Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys., Nat Commun, 5, 3557, 10.1038/ncomms4557

Leeuwenburgh, 2010, Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise., Exp Gerontol, 4, 138, 10.1016/j.exger.2009.11.002

Rabinovitch, 2015, Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects., Aging Cell, 1, 547, 10.1111/acel.12317

Koya, 2010, Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney., J Clin Invest, 12, 1043, 10.1172/JCI41376

Tsuchida, 2015, Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts., Mol Cell Biochem, 40, 1, 10.1007/s11010-015-2327-0

Ungvari, 2014, Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats., Am J Physiol Heart Circ Physiol, 30, H292, 10.1152/ajpheart.00307.2014

Chen, 2012, Age-related changes in the function of autophagy in rat kidneys., Age (Dordr), 3, 329, 10.1007/s11357-011-9237-1

Isobe, 2012, Autophagic activity in thymus and liver during aging., Age (Dordr), 3, 75, 10.1007/s11357-011-9221-9

Tanaka, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice., Nature, 44, 880, 10.1038/nature04723

Levine, 2003, Autophagy genes are essential for dauer development and life-span extension in C. elegans., Science, 30, 1387, 10.1126/science.1087782

Neufeld, 2007, Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila., Genes Dev, 2, 3061, 10.1101/gad.1600707

Kaarniranta, 2009, Regulation of the aging process by autophagy., Trends Mol Med, 1, 217, 10.1016/j.molmed.2009.03.004

Partridge, 2010, Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster., Cell Metab, 1, 35, 10.1016/j.cmet.2009.11.010

Miller, 2012, Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress., Aging Cell, 1, 668, 10.1111/j.1474-9726.2012.00833.x

Miller, 2014, Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice., Aging (Albany NY), 6, 575, 10.18632/aging.100681