Khía cạnh học tập phản hồi bị suy giảm và được bảo tồn ở aMCI: sự đóng góp của tính kết nối cấu trúc

Brain Structure and Function - Tập 221 - Trang 2831-2846 - 2015
Michèle Wessa1, Andrea V. King2, Patric Meyer3, Lutz Frölich4, Herta Flor, Cyril Poupon5, Michael Hoppstädter, Julia Linke3
1Department of Clinical Psychology and Neuropsychology, Institute for Psychology, Johannes Gutenberg University Mainz, Mainz, Germany
2Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
3Department of Clinical Psychology and Neuropsychology, Institute for Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany
4Department of Gerontopsychiatry, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
5NeuroSpin, I2BM, CEA Saclay & Paris-Saclay University, Gif-Sur-Yvette, France

Tóm tắt

Nhiều nghiên cứu đã chỉ ra rằng bệnh nhân mắc chứng suy giảm nhận thức nhẹ mất trí nhớ (aMCI), một tiền đề tiềm năng của bệnh Alzheimer (AD), đặc biệt gặp khó khăn trong việc nhớ các mối quan hệ giữa các đối tượng và việc sử dụng các mục tiêu cảm xúc có thể hỗ trợ trí nhớ ở bệnh nhân mắc AD. Chúng tôi liên kết những phát hiện này bằng cách kiểm tra việc học thông qua phản hồi tích cực và tiêu cực ở bệnh nhân aMCI, đồng thời khám phá các cơ sở giải phẫu của nó bằng cách sử dụng hình ảnh tensor khuếch tán và phân tích đường đi. So với nhóm chứng khỏe mạnh, bệnh nhân aMCI đơn lĩnh vực bị suy giảm khả năng học hỏi từ phản hồi tích cực, trong khi khả năng học hỏi từ kết quả tiêu cực vẫn được bảo tồn. Trong các đường dẫn trong mạch não liên quan đến học hỏi phản hồi, đã quan sát thấy cấu trúc chất trắng bất thường trong các bó dây nối amygdala bên trái với hồi hippocampus và vỏ não entorhinal. Ở tất cả các tham gia viên, sự giảm tính toàn vẹn của chất trắng trong bó dây bên trái này đặc biệt liên quan đến việc học từ kết quả tích cực. Cấu trúc của các bó dây bên phải giữa amygdala và vỏ não entorhinal có liên quan đến việc học từ phản hồi tiêu cực và không bị ảnh hưởng ở bệnh nhân aMCI. Kết quả của chúng tôi cung cấp cái nhìn mới về cách các kết nối giải phẫu có thể góp phần vào các khía cạnh học hỏi bị suy giảm và được bảo tồn trong quá trình bệnh Alzheimer giai đoạn đầu và chỉ ra các cơ chế bù đắp tiềm năng.

Từ khóa

#Suy giảm nhận thức nhẹ mất trí nhớ #bệnh Alzheimer #học từ phản hồi #kết nối giải phẫu #chất trắng.

Tài liệu tham khảo

Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4:316–329 Ashburner J (2007) A fast diffeomorphic image registration algorithm. NeuroImage 38:95–113 Bach M, Laun FB, Leemans A, Tax CM, Biessels GJ, Stieltjes B, Maier-Hein KH (2014) Methodological considerations on tract-based spatial statistics (TBSS). Neuroimage 100:358–369 Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Yuan Y (2009) Abnormal white matter independent of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett 462:147–151 Baker KB, Kim JJ (2004) Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. Behav Neurosci 118:15–23 Bartzokis G (2004) Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease. Neurobiol Aging 25:5–18 Baxter MG, Parker A, Lindner CC, Izquierdo AD, Murray EA (2000) Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. J Neurosci 20:4311–4319 Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system—a technical review. NMR Biomed 15:435–455 Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, Thompson AJ, Brady JM, Matthews PM (2003) Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750–757 Boller F, El Massioui F, Devouche E, Traykov L, Pomati S, Starkstein SE (2002) Processing emotional information in Alzheimer’s disease: effects on memory performance and neurophysiological correlates. Dement Geriatr Cogn Disord 14:104–112 Bosch B, Arenaza-Urquijo EM, Rami L, Sala-Llonch R, Junqué C, Solé-Padullés C, Peña-Gómez C, Bargalló N, Molinuevo JL, Bartrés-Faz D (2012) Multiple DTI index analysis in normal aging, amnestic MCI and AD Relationship with neuropsychological performance. Neurobiol Aging 33:61–74 Brambati SM, Belleville S, Kergoat MJ, Chayer C, Gauthier S, Joubert S (2009) Single- and multiple-domain amnestic mild cognitive impairment: two sides of the same coin? Dement Geriatr Cogn Disord 28:541–549 Brandt J, Spencer M, Folstein M (1988) The telephone interview for cognitive status. Neuropsychiatry Neuropsychol Behav Neurol 1:111–117 Budde M, Xie M, Cross A, Song S (2009) Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci 29:2805–2813 Busatto GF, Diniz BS, Zanetti MV (2008) Voxel-based morphometry in Alzheimer’s disease. Expert Rev Neurother 8:1691–1702 Caffarra P, Ghetti C, Concari L, Venneri A (2008) Differential patterns of hypoperfusion in subtypes of mild cognitive impairment. Open Neuroimag J 2:20–28 Cahill L, McGaugh JL (1998) Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 21:294–299 Carretié L, Albert J, Lopéz-Martín S, Tapia M (2009) Negative brain: an integrative review on the neural processes activated by unpleasant stimuli. Int J Psychophys 71:57–63 Cohen MX, Elger CE, Weber B (2008) Amygdala tractography predicts functional connectivity and learning during feedback-guided decision-making. Neuroimage 39:1396–1407 Coleman-Mesches K, McGaugh JL (1995) Differential involvement of the right and left amygdalae in expression of memory for aversively motivated training. Brain Res 670:75–81 Cortés R, Probst A, Palacios JM (1988) Decreased densities of dopamine D1 receptors in the putamen and hippocampus in senile dementia of the Alzheimer type. Brain Res 475:164–167 Döhnel K, Sommer M, Ibach B, Rothmayr C, Meinhardt J, Hajak G (2008) Neural correlates of emotional working memory in patients with mild cognitive impairment. Neuropsychologia 46:37–48 Eckerström C, Olsson E, Borga M, Ekholm S, Ribbelin S, Rolstad S, Starck G, Edman A, Wallin A, Malmgren H (2008) Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study. J Neurol Sci 272:48–59 Ennis D, Kindlmann G (2006) Orthogonal tensor invariants and the analysis of diffusion tensor magnetic resonance images. Magn Reson Med 55:136–146 Fellgiebel A, Wille P, Müller MJ, Winterer G, Scheurich A, Vucurevic G, Schmidt LG, Stoeter P (2004) Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study. Dement Geriatr Cogn Disord 18:101–108 Fellgiebel A, Müller MJ, Wille P, Dellani PR, Scheurich A, Schmidt LG, Stoeter P (2005) Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiol Aging 26:1193–1198 First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version, nonpatient edition SCID-I/NP. New York State Psychiatric Institute, New York Fischer P, Jungwirth S, Zehetmayer S, Weissgram S, Hoenigschnabl S, Gelpi E, Krampla W, Tragl KH (2007) Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology 68:288–291 Fleming K, Kim SH, Doo M, Maguire G, Potkin SG (2003) Memory for emotional stimuli in patients with Alzheimer’s disease. Am J Alzheimers Dis Other Demen 18:340–342 Frank MJ, Kong L (2008) Learning to avoid in older age. Psychol Aging 23:392–398 Frank MJ, Seeberger LC, O’Reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306:1940–1943 Good CD, Johnsrude IS, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 14:21–36 Gordon EM, Lee PS, Maisog JM, Foss-Feig J, Billington ME, VanMeter J, Vaidya CJ (2010) Strength of default mode resting-state connectivity relates to white matter integrity in children. Dev Sci 14:738–751 Grambaite R, Reinvang I, Selnes P, Fjell AM, Walhovd KB, Stenset V, Fladby T (2011) Pre-dementia memory impairment is associated with white matter tract affection. J Int Neuropsychol Soc 17:143–153 Hahn T, Dresler T, Plichta MM, Ehlis AC, Ernst LH, Markulin F, Polak T, Blaimer M, Deckert J, Lesch KP, Jakob PM, Fallgatter AJ (2010) Functional amygdala-hippocampus connectivity during anticipation of aversive events is associated with Gray’s trait “sensitivity to punishment”. Biol Psychiatry 68:459–464 Hamann S (2001) Cognitive and neural mechanisms of emotional memory. Trends Cogn Sci 5:394–400 Harsan LA, Poulet P, Guignard B, Steibel J, Parizel N, de Sousa PL, Boehm N, Grucker D, Ghandour MS (2006) Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging. J Neurosci Res 83:392–402 Johnson SC, Schmitz TW, Asthana S, Gluck MA, Myers C (2008) Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:129–145 Kalus P, Slotboom J, Gallinat J, Mahlberg R, Cattapan-Ludewig K, Wiest R, Nyffeler T, Buri C, Federspiel A, Kunz D, Schroth G, Kiefer C (2006) Examining the gateway to the limbic system with diffusion tensor imaging: the perforant pathway in dementia. Neuroimage 30:713–720 Karas G, Sluimer J, Goekoop R, van der Flier W, Rombouts SA, Vrenken H, Scheltens P, Fox N, Barkhof F (2008) Amnestic mild cognitive impairment: structural MR imaging findings predictive of conversion to Alzheimer disease. Am J Neuroradiol 29:944–949 Kazui H, Mori E, Hashimoto M, Hirono N, Imamura T, Tanimukai S, Hanihara T, Cahill L (2000) Impact of emotion on memory controlled study of the influence of emotionally charged material on declarative memory in Alzheimer’s disease. Br J Psychiatry 177:343–347 Kazui H, Mori E, Hashimoto M, Hirono N (2003) Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer’s disease. J Neuropsychiatry Clin Neurosci 15:221–226 Kemppainen N, Laine M, Laakso MP, Kaasinen V, Någren K, Vahlberg T, Kurki T, Rinne JO (2003) Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer’s disease. Eur J Neurosci 18:149–154 Kiuchi K, Morikawa M, Taoka T, Nagashima T, Yamauchi T, Makinodan M, Norimoto K, Hashimoto K, Kosaka J, Inoue Y, Inoue M, Kichikawa K, Kishimoto T (2009) Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer’s disease: a diffusion tensor tractography study. Brain Res 1287:184–191 Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M (2007) Genetically determined differences in learning from errors. Science 318:1642–1645 Klingberg T, Roland PE, Kawashima R (1994) The human entorhinal cortex participates in associative memory. Neuroreport 6:57–60 Knutson B, Adams CM, Fong GW, Hommer D (2001) Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21:RC159 Leube DT, Weis S, Freymann K, Erb M, Jessen F, Heun R, Grodd W, Kircher TT (2008) Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease—a VBM study. Int J Geriatr Psychiatry 23: 1114–1118 Linke J, Kirsch P, King AV, Gass A, Hennerici MG, Bongers A, Wessa M (2010) Motivational orientation modulates the neural response to reward. Neuroimage 49:2618–2625 Manly JJ, Bell-McGinty S, Tang MX, Schupf N, Stern Y, Mayeux R (2005) Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community. Arch Neurol 62:1739–1746 Moayeri SE, Cahill L, Jin Y, Potkin SG (2000) Relative sparing of emotionally influenced memory in Alzheimer’s disease. Neuroreport 11:653–655 Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer’s Disease CERAD Part I clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 39:1159–1165 Morris JC (1993) The clinical dementia rating CDR: current version and scoring rules. Neurology 43:2412–2414 Müller MJ, Greverus D, Weibrich C, Dellani PR, Scheurich A, Stoeter P, Fellgiebel A (2007) Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI. Neurobiol Aging 28:398–403 O’Doherty JP (2004) Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol 14:769–776 Paz R, Pelletier JG, Bauer EP, Paré D (2006) Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions. Nat Neurosci 9:1321–1329 Peper M, Karcher S, Wohlfarth R, Reinshagen G, LeDoux JE (2001) Aversive learning in patients with unilateral lesions of the amygdala and hippocampus. Biol Psychol 58:1–23 Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56:303–308 Pierpaoli C, Basser PJ (1996) Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893–906 Prigatano GP, Fordyce DJ, Zeiner HK, Roueche JR, Pepping M, Wood BC (1986) Neuropsychological rehabilitation after brain injury. John Hopkins University Press, Baltimore Ravaglia G, Forti P, Maioli F, Martelli M, Servadei L, Brunetti N, Pantieri G, Mariani E (2006) Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement Geriatr Cogn Disord 21:51–58 Rogalski EJ, Murphy CM, deToledo-Morrell L, Shah RC, Moseley ME, Bammer R, Stebbins GT (2009) Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study. Behav Neurol 21:51–61 Rose SE, McMahon KL, Janke AL, O’Dowd B, de Zubicaray G, Strudwick MW, Chalk JB (2006) Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment. J Neurol Neurosurg Psychiatry 77:1122–1128 Rueckert D, Sonoda LI, Hayes C, Hill DLG, Leach MO, Hawkes DJ (1999) Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans Med Imag 18:712–721 Seo SW, Im K, Lee JM, Kim YH, Kim ST, Kim SY, Yang DW, Kim SI, Cho YS, Na DL (2007) Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment. Neuroimage 36:289–297 Sexton CE, Kalu UG, Filippini N, Mackay CE, Ebmeier KP (2011) A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer’s disease. Neurobiol Aging 32:2322.e5–2322.e18 Shi F, Liu B, Zhou Y, Yu C, Jiang T (2009) Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer’s disease: meta-analyses of MRI studies. Hippocampus 19:1055–1064 Simon JR, Howard JH, Howard DV (2010) Adult age differences in learning from positive and negative probabilistic feedback. Neuropsychology 24:534–541 Slavin MJ, Sandstrom CK, Tran TT, Doraiswamy PM, Petrella JR (2007) Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment. Am J Roentgenol 188:1404–1410 Smith SM, Nichols TE (2009) Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 44:83–98 Smith S (2002) Fast robust automated brain extraction. Human Brain Mapping 17:143–155 Smith S, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols T, Mackay C, Watkins K, Ciccarelli O, Cader M, Matthews P (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31:1487–1505 Song S, Sun S, Ramsbottom M, Chang C, Russell J, Cross A (2002) Dysmyelination revealed through MRI as increased radial but unchanged axial diffusion of water. Neuroimage 17:1429–1436 Stebbins GT, Murphy CM (2009) Diffusion tensor imaging in Alzheimer’s disease and mild cognitive impairment. Behav Neurol 21:39–49 Stoub TR, Rogalski EJ, Leurgans S, Bennett DA, deToledo-Morrell L (2010) Rate of entorhinal and hippocampal atrophy in incipient and mild AD: relation to memory function. Neurobiol Aging 31:1089–1098 Taylor Tavares JV, Clark L, Furey ML, Williams GB, Sahakian BJ, Drevets WC (2008) Neural basis of abnormal response to negative feedback in unmedicated mood disorders. Neuroimage 42:1118–1126 Thompson PM, Hayashi KM, Dutton RA, Chiang MC, Leow AD, Sowell ER, De Zubicaray G, Becker JT, Lopez OL, Aizenstein HJ, Toga AW (2007) Tracking Alzheimer’s disease. Ann N Y Acad Sci 1097:183–214 Troyer AK, Murphy KJ, Anderson ND, Hayman-Abello BA, Craik FI, Moscovitch M (2008) Item and associative memory in amnestic mild cognitive impairment: performance on standardized memory tests. Neuropsychology 22:10–16 Walhovd KB, Fjell AM, Amlien I, Grambaite R, Stenset V, Bjørnerud A, Reinvang I, Gjerstad L, Cappelen T, Due-Tønnessen P, Fladby T (2009) Multimodal imaging in mild cognitive impairment: metabolism, morphometry and diffusion of the temporal-parietal memory network. Neuroimage 45:215–223 Wang Z, Guo X, Qi Z, Yao L, Li K (2010) Whole-brain voxel-based morphometry of white matter in mild cognitive impairment. Eur J Radiol 75:129–133 Wechsler D (1987) Wechsler memory scale-revised. Harcourt Brace Jovanovich, New York Whitwell JL, Petersen RC, Negash S, Weigand SD, Kantarci K, Ivnik RJ, Knopman DS, Boeve BF, Smith GE, Jack CR (2007) Patterns of atrophy differ among specific subtypes of mild cognitive impairment. Arch Neurol 64:1130–1138 Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256:240–246 Yonelinas AP, Hopfinger JB, Buonocore MH, Kroll NE, Baynes K (2001) Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study. Neuroreport 12:359–363 Zalla T, Koechlin E, Pietrini P, Basso G, Aquino P, Sirigu A, Grafman J (2000) Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans. Eur J Neurosci 12:1764–1770