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Khía cạnh học tập phản hồi bị suy giảm và được bảo tồn ở aMCI: sự đóng góp của tính kết nối cấu trúc
Tóm tắt
Nhiều nghiên cứu đã chỉ ra rằng bệnh nhân mắc chứng suy giảm nhận thức nhẹ mất trí nhớ (aMCI), một tiền đề tiềm năng của bệnh Alzheimer (AD), đặc biệt gặp khó khăn trong việc nhớ các mối quan hệ giữa các đối tượng và việc sử dụng các mục tiêu cảm xúc có thể hỗ trợ trí nhớ ở bệnh nhân mắc AD. Chúng tôi liên kết những phát hiện này bằng cách kiểm tra việc học thông qua phản hồi tích cực và tiêu cực ở bệnh nhân aMCI, đồng thời khám phá các cơ sở giải phẫu của nó bằng cách sử dụng hình ảnh tensor khuếch tán và phân tích đường đi. So với nhóm chứng khỏe mạnh, bệnh nhân aMCI đơn lĩnh vực bị suy giảm khả năng học hỏi từ phản hồi tích cực, trong khi khả năng học hỏi từ kết quả tiêu cực vẫn được bảo tồn. Trong các đường dẫn trong mạch não liên quan đến học hỏi phản hồi, đã quan sát thấy cấu trúc chất trắng bất thường trong các bó dây nối amygdala bên trái với hồi hippocampus và vỏ não entorhinal. Ở tất cả các tham gia viên, sự giảm tính toàn vẹn của chất trắng trong bó dây bên trái này đặc biệt liên quan đến việc học từ kết quả tích cực. Cấu trúc của các bó dây bên phải giữa amygdala và vỏ não entorhinal có liên quan đến việc học từ phản hồi tiêu cực và không bị ảnh hưởng ở bệnh nhân aMCI. Kết quả của chúng tôi cung cấp cái nhìn mới về cách các kết nối giải phẫu có thể góp phần vào các khía cạnh học hỏi bị suy giảm và được bảo tồn trong quá trình bệnh Alzheimer giai đoạn đầu và chỉ ra các cơ chế bù đắp tiềm năng.
Từ khóa
#Suy giảm nhận thức nhẹ mất trí nhớ #bệnh Alzheimer #học từ phản hồi #kết nối giải phẫu #chất trắng.Tài liệu tham khảo
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