Impact of the gut microbiota on chemical risk assessment

Sender, 2016, Revised estimates for the number of human and bacteria cells in the body, PLoS Biol, 14, e1002533, 10.1371/journal.pbio.1002533 Qin, 2010, A human gut microbial gene catalogue established by metagenomic sequencing, Nature, 464, 59, 10.1038/nature08821 Sommer, 2013, The gut microbiota–masters of host development and physiology, Nat Rev Microbiol, 11, 227, 10.1038/nrmicro2974 Claus, 2016, The gut microbiota: a major player in the toxicity of environmental pollutants?, npj Biofilms Microbiomes, 2, 16003, 10.1038/npjbiofilms.2016.3 Suez, 2014, Artificial sweeteners induce glucose intolerance by altering the gut microbiota, Nature, 514, 181, 10.1038/nature13793 Chassaing, 2017, Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation, Gut, 66, 1414, 10.1136/gutjnl-2016-313099 Spanogiannopoulos, 2016, The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism, Nat Rev Microbiol, 14, 273, 10.1038/nrmicro.2016.17 De Santis, 2015, Nutritional keys for intestinal barrier modulation, Front Immunol, 6, 612, 10.3389/fimmu.2015.00612 Xu, 2014, Changes in gut microbiota may be early signs of liver toxicity induced by epoxiconazole in rats, Chemotherapy, 60, 135, 10.1159/000371837 Nasuti, 2016, Changes on fecal microbiota in rats exposed to permethrin during postnatal development, Environ Sci Pollut Res, 23, 10930, 10.1007/s11356-016-6297-x Ackermann, 2015, The influence of glyphosate on the microbiota and production of botulinum neurotoxin during ruminal fermentation, Curr Microbiol, 70, 374, 10.1007/s00284-014-0732-3 Steinrucken, 1984, 5-Enolpyruvylshikimate-3-phosphate synthase of Klebsiella pneumoniae 2. Inhibition by glyphosate [N-(phosphonomethyl)glycine], Eur J Biochem, 143, 351, 10.1111/j.1432-1033.1984.tb08379.x Steinrücken, 1980, The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase, Biochem Biophys Res Commun, 94, 1207, 10.1016/0006-291X(80)90547-1 2002 Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science (80- ), 341, 10.1126/science.1241214 Thomas Zoeller, 2012, Endocrine-disrupting chemicals and public health protection: a statement of principles from the Endocrine Society, Endocrinology, 153, 4097, 10.1210/en.2012-1422 Lai, 2016, Bisphenol A alters gut microbiome: comparative metagenomics analysis, Environ Pollut, 218, 923, 10.1016/j.envpol.2016.08.039 Shehata, 2013, The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro, Curr Microbiol, 66, 350, 10.1007/s00284-012-0277-2 Rettedal, 2014, Cultivation-based multiplex phenotyping of human gut microbiota allows targeted recovery of previously uncultured bacteria, Nat Commun, 5, 4714, 10.1038/ncomms5714 Nielsen, 2017, Glyphosate has limited short-term effects on commensal bacterial community composition in the gut environment due to sufficient aromatic amino acid levels, Environ Pollut, 233, 364, 10.1016/j.envpol.2017.10.016 Li, 2017, Novel interactions between gut microbiome and host drug-processing genes modify the hepatic metabolism of the environmental chemicals polybrominated diphenyl ethers, Drug Metab Dispos, 45, 1197, 10.1124/dmd.117.077024 Tulstrup, 2018, Antibiotic treatment of rat dams affects bacterial colonization and causes decreased weight gain in pups, Commun Biol, 1, 10.1038/s42003-018-0140-5 Phelps, 2017, Microbial colonization is required for normal neurobehavioral development in zebrafish, Sci Rep, 7, 11244, 10.1038/s41598-017-10517-5 Ezcurra, 2018, Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system, Biogerontology, 10.1007/s10522-018-9752-x Daisley, 2018, Microbiota-mediated modulation of organophosphate insecticide toxicity by species-dependent lactobacilli interactions in a Drosophila melanogaster insect model, Appl Environ Microbiol, 10.1128/AEM.02820-17 Zhang, 2017, Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans, ISME J, 11, 676, 10.1038/ismej.2016.151 Boberg, 2016, Multiple endocrine disrupting effects in rats perinatally exposed to butylparaben, Toxicol Sci, 152, 244, 10.1093/toxsci/kfw079 Xiao, 2015, A catalog of the mouse gut metagenome, Nat Biotechnol, 33, 10.1038/nbt.3353 Tulstrup, 2015, Antibiotic treatment affects intestinal permeability and gut microbial composition in wistar rats dependent on antibiotic class, PLoS One, 10, e0144854, 10.1371/journal.pone.0144854 Hacquard, 2015, Microbiota and host nutrition across plant and animal kingdoms, Cell Host Microbe, 17, 603, 10.1016/j.chom.2015.04.009 Chung, 2012, Gut immune maturation depends on colonization with a host-specific microbiota, Cell, 149, 1578, 10.1016/j.cell.2012.04.037 Mack, 2003, Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro, Gut, 52, 827, 10.1136/gut.52.6.827 Bergström, 2012, Nature of bacterial colonization influences transcription of mucin genes in mice during the first week of life, BMC Res Notes, 5, 402, 10.1186/1756-0500-5-402 Gill, 2007, Effect of fecal water on an in vitro model of colonic mucosal barrier function, NutrCancer, 57, 59 Sousa, 2008, The gastrointestinal microbiota as a site for the biotransformation of drugs, Int J Pharm, 363, 1, 10.1016/j.ijpharm.2008.07.009 Koppel, 2017, Chemical transformation of xenobiotics by the human gut microbiota, Science (80- ), 356, eaag2770, 10.1126/science.aag2770 Van de Wiele, 2005, Human colon microbiota transform polycyclic aromatic hydrocarbons to estrogenic metabolites, Environ Health Perspect, 113, 6, 10.1289/ehp.7259 Bjorkholm, 2009, Intestinal microbiota regulate xenobiotic metabolism in the liver, PLoS One, 4, e6958, 10.1371/journal.pone.0006958 Bakke, 1986, Role of intestinal flora in metabolism of agrochemicals conjugated with glutathione, Xenobiotica, 16, 1047, 10.3109/00498258609038982 Alexander, 2017, Gut microbiota modulation of chemotherapy efficacy and toxicity, Nat Rev Gastroenterol Hepatol, 14, 356, 10.1038/nrgastro.2017.20 Hildebrand, 2012, A comparative analysis of the intestinal metagenomes present in Guinea pigs (Cavia porcellus) and humans (Homo sapiens), BMC Genomics, 13, 514, 10.1186/1471-2164-13-514 Turnbaugh, 2009, A core gut microbiome in obese and lean twins, Nature, 457, 480, 10.1038/nature07540 McCoy, 2017, Gut microbiome standardization in control and experimental mice