Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
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Anders, 2013, The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease, Kidney Int., 83, 1010, 10.1038/ki.2012.440
Anderson, 2015, The gut–brain axis: the role of melatonin in linking psychiatric, inflammatory and neurodegenerative conditions, Adv. Integr. Med., 2, 31, 10.1016/j.aimed.2014.12.007
Anderson, 2016, Gut permeability and microbiota in parkinson disease: role of depression, tryptophan catabolites, oxidative and nitrosative stress and melatonergic pathways, Curr. Pharm. Des., 22, 6142, 10.2174/1381612822666160906161513
Arsenescu, 2011, Role of the xenobiotic receptor in inflammatory bowel disease, Inflamm. Bowel Dis., 17, 1149, 10.1002/ibd.21463
Badawy, 2015, Tryptophan metabolism, disposition and utilization in pregnancy, Biosci. Rep., 35, e00261, 10.1042/BSR20150197
Bai, 2017, A review of the immunomodulatory role of dietary tryptophan in livestock and poultry, Amino Acids, 49, 67, 10.1007/s00726-016-2351-8
Bailey, 2014, Influence of stressor-induced nervous system activation on the intestinal microbiota and the importance for immunomodulation, Adv. Exp. Med. Biol., 817, 255, 10.1007/978-1-4939-0897-4_12
Balsari, 1982, The fecal microbial population in the irritable bowel syndrome, Microbiologica, 5, 185
Bansal, 2010, The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation, Proc. Natl. Acad. Sci. U.S.A., 107, 228, 10.1073/pnas.0906112107
Behnsen, 2014, The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria, Immunity, 40, 262, 10.1016/j.immuni.2014.01.003
Benson, 2011, Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with crohn's disease, Toxicol. Sci., 120, 68, 10.1093/toxsci/kfq360
Bessede, 2014, Aryl hydrocarbon receptor control of a disease tolerance defence pathway, Nature, 511, 184, 10.1038/nature13323
Bhattarai, 2017, Irritable bowel syndrome: a gut microbiota-related disorder?, Am. J. Physiol. Gastrointest. Liver Physiol., 312, G52, 10.1152/ajpgi.00338.2016
Biagi, 2012, Aging of the human metaorganism: the microbial counterpart, Age, 34, 247, 10.1007/s11357-011-9217-5
Biagi, 2013, Ageing and gut microbes: perspectives for health maintenance and longevity, Pharmacol. Res., 69, 11, 10.1016/j.phrs.2012.10.005
Bischoff, 2009, Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice, Am. J. Physiol. Gastrointest. Liver Physiol., 296, G685, 10.1152/ajpgi.90685.2008
Bittinger, 2003, Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor, Mol. Pharmacol., 64, 550, 10.1124/mol.64.3.550
Blumberg, 2012, Microbiota, disease, and back to health: a metastable journey, Sci. Transl. Med., 4, 137r, 10.1126/scitranslmed.3004184
Bubenik, 1977, Immunohistological localization of melatonin in the rat digestive system, Experientia, 33, 662, 10.1007/BF01946561
Campbell, 2014, Kynurenines in CNS disease: regulation by inflammatory cytokines, Front. Neurosci., 8, 12, 10.3389/fnins.2014.00012
Cerf-Bensussan, 2012, The dialog between microbiota and the immune system: shaping the partners through development and evolution, Semin. Immunol., 24, 1, 10.1016/j.smim.2011.11.007
Cheng, 2013, Contribution of the intestinal microbiota to human health: from birth to 100 years of age, Curr. Top. Microbiol. Immunol., 358, 323, 10.1007/82_2011_189
Cheng, 2015, Aryl hydrocarbon receptor activity of tryptophan metabolites in young adult mouse colonocytes, Drug Metab. Disposit., 43, 1536, 10.1124/dmd.115.063677
Chimerel, 2014, Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells, Cell Rep., 9, 1202, 10.1016/j.celrep.2014.10.032
Chung, 2011, Possible roles of excess tryptophan metabolites in cancer, Environ. Mol. Mutagen., 52, 81, 10.1002/em.20588
Ciorba, 2010, Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis, J. Immunol., 184, 3907, 10.4049/jimmunol.0900291
Clarke, 2013, The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner, Mol. Psychiatry, 18, 666, 10.1038/mp.2012.77
Clarke, 2012, A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of toll-like receptor activation in irritable bowel syndrome, Front. Pharmacol., 3, 90, 10.3389/fphar.2012.00090
Clarke, 2009, Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood, Behav. Brain Res., 205, 319, 10.1016/j.bbr.2009.07.008
Clarke, 2014, Minireview: gut microbiota: the neglected endocrine organ, Mol. Endocrinol., 28, 1221, 10.1210/me.2014-1108
Collino, 2013, Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism, PLoS ONE, 8, e56564, 10.1371/annotation/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd
Cook, 2007, Characterization of skatole-producing microbial populations in enriched swine lagoon slurry, FEMS Microbiol. Ecol., 60, 329, 10.1111/j.1574-6941.2007.00299.x
Cooper, 2000, Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation, Carcinogenesis, 21, 757, 10.1093/carcin/21.4.757
Coste, 2007, LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease, Proc. Natl. Acad. Sci. U.S.A., 104, 13098, 10.1073/pnas.0702440104
Costello, 2014, Intestinal dysbiosis in ankylosing spondylitis, Arthritis Rheumatol, 67, 686, 10.1002/art.38967
Cox, 2010, Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes, Br. J. Sports Med., 44, 222, 10.1136/bjsm.2007.044628
Dai, 2010, Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions, J. Histochem. Cytochem., 58, 17, 10.1369/jhc.2009.953604
Davis, 2014, Exploring the Effects of Gut-Derived Microbial Metabolites on Expression of SPI-1 Genes and Antimicrobial Resistance in Salmonella Typhimurium[D]
De Luca, 2010, IL-22 defines a novel immune pathway of antifungal resistance, Mucosal Immunol., 3, 361, 10.1038/mi.2010.22
De Mello, 1980, Excited indole-3-aldehyde from the peroxidase-catalyzed aerobic oxidation of indole-3-acetic acid. Reaction with and energy transfer to transfer ribonucleic acid, Biochemistry, 19, 5270, 10.1021/bi00564a019
Desbonnet, 2008, The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat, J. Psychiatr. Res., 43, 164, 10.1016/j.jpsychires.2008.03.009
El Aidy, 2012, The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine, Benef. Microbes, 3, 251, 10.3920/BM2012.0042
Engberg, 2000, Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers, Poult. Sci., 79, 1311, 10.1093/ps/79.9.1311
Engin, 2015, Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer, World J. Gastroenterol., 21, 3636, 10.3748/wjg.v21.i12.3636
Essien, 2013, ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against salmonella typhimurium in mice, Gastroenterology, 144, 1466.e1469, 10.1053/j.gastro.2013.01.057
Etienne-Mesmin, 2017, Tryptophan: a gut microbiota-derived metabolites regulating inflammation, World J. Gastrointest. Pharmacol. Ther., 8, 7, 10.4292/wjgpt.v8.i1.7
Fantini, 2009, Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies, World J. Gastroenterol., 15, 2472, 10.3748/wjg.15.2472
Ferdinande, 2012, Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer, Br. J. Cancer, 106, 141, 10.1038/bjc.2011.513
Fitzgerald, 2008, Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity, Neurogastroenterol. Motil., 20, 1291, 10.1111/j.1365-2982.2008.01195.x
Flint, 2012, The role of the gut microbiota in nutrition and health, Nat. Rev. Gastroenterol. Hepatol., 9, 577, 10.1038/nrgastro.2012.156
Forrest, 2003, Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease, Developments in Tryptophan and Serotonin Metabolism, 395, 10.1007/978-1-4615-0135-0_46
Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N. Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x
Frank, 2007, Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc. Natl. Acad. Sci.U.S.A., 104, 13780, 10.1073/pnas.0706625104
Freewan, 2013, Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide, J. Biol. Chem., 288, 1548, 10.1074/jbc.M112.410993
Galley, 2014, Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis, J. Pineal Res., 56, 427, 10.1111/jpi.12134
García-Lara, 2015, Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress, J. Neurosci. Res., 93, 1423, 10.1002/jnr.23595
Genestet, 2014, Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing, Free Radic. Biol. Med., 73, 400, 10.1016/j.freeradbiomed.2014.06.003
Gershon, 2007, The serotonin signaling system: from basic understanding to drug development for functional GI disorders, Gastroenterology, 132, 397, 10.1053/j.gastro.2006.11.002
Gkouskou, 2014, The gut microbiota in mouse models of inflammatory bowel disease, Front. Cell. Infect. Microbiol., 4, 28, 10.3389/fcimb.2014.00028
Glenister, 2013, Therapeutic actions of melatonin on gastrointestinal cancer development and progression, Transl. Gastrointest. Cancer, 2, 11, 10.3978/j.issn.2224-4778.2012.08.03
Grant, 1999, Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?, Arch. Biochem. Biophys., 372, 1, 10.1006/abbi.1999.1381
Grivennikov, 2012, Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth, Nature, 491, 254, 10.1038/nature11465
Gupta, 2012, Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity, Inflamm. Bowel Dis., 18, 1214, 10.1002/ibd.21849
Gurkar, 2015, Comparison of mice with accelerated aging caused by distinct mechanisms, Exp. Gerontol., 68, 43, 10.1016/j.exger.2015.01.045
Hamard, 2007, Intestinal development and growth performance of early-weaned piglets fed a low-threonine diet, Animal, 1, 1134, 10.1017/S1751731107000560
Hansen, 2000, Effect of fermented liquid food and zinc bacitracin on microbial metabolism in the gut and sensoric profile of m. longissimus dorsi from entire male and female pigs, Anim. Sci., 71, 65, 10.1017/S1357729800054904
Hashimoto, 2012, ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation, Nature, 487, 477, 10.1038/nature11228
Hasnain, 2013, IL-10 Promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells, Gastroenterology, 144, 357.e359, 10.1053/j.gastro.2012.10.043
Haverback, 1960, Indole metabolism in the malabsorption syndrome, N. Engl. J. Med., 262, 754, 10.1056/NEJM196004142621504
Hold, 2014, Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?, World J. Gastroenterol., 20, 1192, 10.3748/wjg.v20.i5.1192
Hong, 2014, Unraveling the ties between irritable bowel syndrome and intestinal microbiota, World J. Gastroenterol., 20, 2470, 10.3748/wjg.v20.i10.2470
Honneffer, 2015, Mo1805 untargeted metabolomics reveals disruption within bile acid, cholesterol, and tryptophan metabolic pathways in dogs with idiopathic inflammatory bowel disease, Gastroenterology, 148, S-715, 10.1016/S0016-5085(15)32435-5
Hooper, 2012, Interactions between the microbiota and the immune system, Science, 336, 1268, 10.1126/science.1223490
Høverstad, 1986, Short-chain fatty acids in germfree mice and rats, J. Nutr., 116, 1772, 10.1093/jn/116.9.1772
Huang, 2002, Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer, Br. J. Cancer, 86, 1691, 10.1038/sj.bjc.6600336
Huang, 2014, Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis, Sci. Signal., 7, ra20, 10.1126/scisignal.2004786
Hubbard, , Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles, Sci. Rep., 5, 12689, 10.1038/srep12689
Hubbard, , Indole and tryptophan metabolism: endogenous and dietary routes to ah receptor activation, Drug Metab. Disposit., 43, 1522, 10.1124/dmd.115.064246
Islam, 2017, Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice, J. Nutr. Biochem., 42, 43, 10.1016/j.jnutbio.2016.12.019
Jenkins, 2016, Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis, Nutrients, 8, 56, 10.3390/nu8010056
Jensen, 1995, 3-Methylindole (skatole) and indole production by mixed populations of pig fecal bacteria, Appl. Environ. Microbiol., 61, 3180, 10.1128/AEM.61.8.3180-3184.1995
Jia, 2012, Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease, FEMS Immunol. Med. Microbiol., 65, 55, 10.1111/j.1574-695X.2012.00935.x
Kang, 2015, Downregulation of tryptophan-related metabolomic profile in rheumatoid arthritis synovial fluid, J. Rheumatol., 42, 2003, 10.3899/jrheum.141505
Kashyap, 2013, Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice, Gastroenterology, 144, 967, 10.1053/j.gastro.2013.01.047
Kaszaki, 2008, Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs, Neurogastroenterol. Motil., 20, 53, 10.1111/j.1365-2982.2007.00989.x
Katz, 2008, Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape, Immunol. Rev., 222, 206, 10.1111/j.1600-065X.2008.00610.x
Kawai, 2010, The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat. Immunol., 11, 373, 10.1038/ni.1863
Keszthelyi, 2009, Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function, Neurogastroenterol. Motil., 21, 1239, 10.1111/j.1365-2982.2009.01370.x
Kilkens, 2004, Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls, Gut, 53, 1794, 10.1136/gut.2004.041657
Kim, 2010, l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis, J. Nutr. Biochem., 21, 468, 10.1016/j.jnutbio.2009.01.019
Kim, 2014, Stimulation of the alpha7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation, J. Infect. Dis., 209, 1668, 10.1093/infdis/jit669
Knarreborg, 2002, Effect of non-starch polysaccharides on production and absorption of indolic compounds in entire male pigs, Anim. Sci., 74, 445, 10.1017/S1357729800052590
Korecka, 2016, Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism, npj Biofilms Microbiomes, 2, 16014, 10.1038/npjbiofilms.2016.14
Kostic, 2014, The microbiome in inflammatory bowel disease: current status and the future ahead, Gastroenterology, 146, 1489, 10.1053/j.gastro.2014.02.009
Lamas, 2017, Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases, Curr. Opin. Clin. Nutr. Metab. Care, 20, 243, 10.1097/MCO.0000000000000382
Lamas, 2016, CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands, Nat. Med., 22, 598, 10.1038/nm.4102
Lawrence, 2008, Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II, Arthritis Rheumat., 58, 26, 10.1002/art.23176
Le Floc'h, 2011, Tryptophan metabolism, from nutrition to potential therapeutic applications, Amino Acids, 41, 1195, 10.1007/s00726-010-0752-7
Lee, 2012, AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch, Nat. Immunol., 13, 144, 10.1038/ni.2187
Lesurtel, 2008, Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives, Cell. Mol. Life Sci., 65, 940, 10.1007/s00018-007-7377-3
Levin, 2014, Selective inhibition of mucosal serotonin as treatment for IBD?, Gut, 63, 866, 10.1136/gutjnl-2013-305283
Levy, 2016, Microbiome, metabolites and host immunity, Curr. Opin. Microbiol., 35, 8, 10.1016/j.mib.2016.10.003
Li, 2013, Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan, Microbiology, 159, 402, 10.1099/mic.0.064139-0
Linden, 2003, Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis, Am. J. Physiol. Gastrointest. Liver Physiol., 285, G207, 10.1152/ajpgi.00488.2002
Linden, 2005, Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis, Neurogastroenterol. Motil., 17, 565, 10.1111/j.1365-2982.2005.00673.x
Liu, 2010, Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity, Blood, 115, 3520, 10.1182/blood-2009-09-246124
Liu, 2017, Roles of amino acids in preventing and treating intestinal diseases: recent studies with pig models, Amino Acids, 49, 1277, 10.1007/s00726-017-2450-1
Llopis, 2009, Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa, Inflamm. Bowel Dis., 15, 275, 10.1002/ibd.20736
Lowe, 2014, Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production, PLoS ONE, 9, e87877, 10.1371/journal.pone.0087877
Lundgren, 1998, 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion, Gastroenterology, 115, 1009, 10.1016/S0016-5085(98)70275-6
Maes, 2007, The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation, Neuro Endocrinol. Lett., 28, 826
Marcobal, 2013, A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice, ISME J., 7, 1933, 10.1038/ismej.2013.89
Mardinoglu, 2015, The gut microbiota modulates host amino acid and glutathione metabolism in mice, Mol. Syst. Biol., 11, 834, 10.15252/msb.20156487
Margolis, 2013, Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine, Gut, 63, 928, 10.1136/gutjnl-2013-304901
Markus, 2010, Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?, Pharmacol. Ther., 126, 251, 10.1016/j.pharmthera.2010.02.009
Marsland, 2016, Regulating inflammation with microbial metabolites, Nat. Med., 22, 581, 10.1038/nm.4117
Martin-Subero, 2015, Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways, CNS Spectr., 21, 184, 10.1017/S1092852915000449
Maslowski, 2009, Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43, Nature, 461, 1282, 10.1038/nature08530
Matsuoka, 2015, The gut microbiota and inflammatory bowel disease, Semin. Immunopathol., 37, 47, 10.1007/s00281-014-0454-4
Mosa, 2016, Products of gut-microbial tryptophan metabolism inhibit the steroid hormone-synthesizing cytochrome P450 11A1, Endocrine, 53, 610, 10.1007/s12020-016-0874-0
Muller, 2006, Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors, Nat. Rev. Cancer, 6, 613, 10.1038/nrc1929
Muller, 2005, Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy, Nat. Med., 11, 312, 10.1038/nm1196
Munn, 2007, Indoleamine 2,3-dioxygenase and tumor-induced tolerance, J. Clin. Investig., 117, 1147, 10.1172/JCI31178
Nagata, 2016, The effectiveness of lactobacillus beverages in controlling infections among the residents of an aged care facility: a randomized placebo-controlled double-blind trial, Ann. Nutr. Metab., 68, 51, 10.1159/000442305
Nakai, 2003, Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mapping, Can. J. Gastroenterol., 17, 191, 10.1155/2003/572127
Nemoto, 2012, Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis, Dig. Dis. Sci., 57, 2955, 10.1007/s10620-012-2236-y
Nicholson, 2003, Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism, Nat. Rev. Drug Discov., 2, 668, 10.1038/nrd1157
Niño-Castro, 2014, The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes, Innate Immun., 20, 401, 10.1177/1753425913496442
Notarangelo, 2014, Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia, Schizophr. Res., 152, 261, 10.1016/j.schres.2013.11.011
Nowak, 2006, Influence of phenol, p-cresol and indole on growth and survival of intestinal lactic acid bacteria, Anaerobe, 12, 80, 10.1016/j.anaerobe.2005.10.003
O'mahony, 2015, Serotonin, tryptophan metabolism and the brain-gut-microbiome axis, Behav. Brain Res., 277, 32, 10.1016/j.bbr.2014.07.027
Opitz, 2011, An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor, Nature, 478, 197, 10.1038/nature10491
Oxenkrug, 2010, Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism, Ann. N. Y. Acad. Sci., 1199, 1, 10.1111/j.1749-6632.2009.05356.x
Peters, 1991, Tryptophan nutrition and metabolism: an overview, Adv. Exp. Med. Biol., 294, 345, 10.1007/978-1-4684-5952-4_32
Pillai, 2013, Rethinking mechanisms of autoimmune pathogenesis, J. Autoimmun., 45, 97, 10.1016/j.jaut.2013.05.003
Png, 2010, Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria, Am. J. Gastroenterol., 105, 2420, 10.1038/ajg.2010.281
Puel, 2010, Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I, J. Exp. Med., 207, 291, 10.1084/jem.20091983
Qiu, 2012, The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells, Immunity, 36, 92, 10.1016/j.immuni.2011.11.011
Radogna, 2010, Melatonin: a pleiotropic molecule regulating inflammation, Biochem. Pharmacol., 80, 1844, 10.1016/j.bcp.2010.07.041
Raman, 2013, Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer, Gut Microbes, 4, 181, 10.4161/gmic.23919
Rampelli, 2013, Functional metagenomic profiling of intestinal microbiome in extreme ageing, Aging, 5, 902, 10.18632/aging.100623
Reigstad, 2015, Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells, FASEB J., 29, 1395, 10.1096/fj.14-259598
Ridaura, 2015, Gut microbiota: the link to your second brain, Cell, 161, 193, 10.1016/j.cell.2015.03.033
Romani, 2014, Microbiota control of a tryptophan–AhR pathway in disease tolerance to fungi, Eur. J. Immunol., 44, 3192, 10.1002/eji.201344406
Rooks, 2016, Gut microbiota, metabolites and host immunity, Nat. Rev. Immunol., 16, 341, 10.1038/nri.2016.42
Rowan, 2010, Desulfovibrio bacterial species are increased in ulcerative colitis, Dis. Colon Rectum, 53, 1530, 10.1007/DCR.0b013e3181f1e620
Ruddick, 2006, Tryptophan metabolism in the central nervous system: medical implications, Expert Rev. Mol. Med., 8, 1, 10.1017/S1462399406000068
Salazar, 2014, The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations, Front. Genet., 5, 406, 10.3389/fgene.2014.00406
Salazar, 2016, Nutrition and the gut microbiome in the elderly, Gut Microbes, 8, 82, 10.1080/19490976.2016.1256525
Santhanam, 2016, Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer, Transl. Res., 167, 67, 10.1016/j.trsl.2015.07.003
Sartor, 2004, Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics, Gastroenterology, 126, 1620, 10.1053/j.gastro.2004.03.024
Sartor, 2008, Microbial influences in inflammatory bowel diseases, Gastroenterology, 134, 577, 10.1053/j.gastro.2007.11.059
Scher, 2015, Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease, Arthritis Rheumatol., 67, 128, 10.1002/art.38892
Schiering, 2017, Feedback control of AHR signalling regulates intestinal immunity, Nature, 542, 242, 10.1038/nature21080
Shi, 2007, The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice, J. Immunol., 179, 6952, 10.4049/jimmunol.179.10.6952
Shi, 2008, Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders, J. Med. Chem., 51, 3684, 10.1021/jm800338j
Shimada, 2013, Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon, PLoS ONE, 8, e80604, 10.1371/journal.pone.0080604
Shufflebotham, 2006, Acute tryptophan depletion alters gastrointestinal and anxiety symptoms in irritable bowel syndrome, Am. J. Gastroenterol., 101, 2582, 10.1111/j.1572-0241.2006.00811.x
Smith, 1997, Formation of phenolic and indolic compounds by anaerobic bacteria in the human large intestine, Microb. Ecol., 33, 180, 10.1007/s002489900020
Soares, 2014, Irritable bowel syndrome: a clinical review, World J. Gastroenterol., 20, 12144, 10.3748/wjg.v20.i34.12144
Sokol, 2008, Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients, Proc. Natl. Acad. Sci. U.S.A., 105, 16731, 10.1073/pnas.0804812105
Sommansson, 2013, Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor–dependent pathway in rats in vivo, J. Pineal Res., 54, 282, 10.1111/jpi.12013
Spiller, 2008, Serotonin and GI clinical disorders, Neuropharmacology, 55, 1072, 10.1016/j.neuropharm.2008.07.016
Stoll, 2016, Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors, Genes Immun., 17, 400, 10.1038/gene.2016.38
Stoll, 2014, Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis, Arthritis Res. Ther., 16, 486, 10.1186/s13075-014-0486-0
Strauss, 2011, Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host, Inflamm. Bowel Dis., 17, 1971, 10.1002/ibd.21606
Sudo, 2004, Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice, J. Physiol., 558, 263, 10.1113/jphysiol.2004.063388
Sun, 2013, Melatonin reduces bacterial translocation by preventing damage to the intestinal mucosa in an experimental severe acute pancreatitis rat model, Exp. Ther. Med., 6, 1343, 10.3892/etm.2013.1338
Sutter, 2011, 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation, Toxicol. Sci., 124, 128, 10.1093/toxsci/kfr205
Takaki, 1985, Physiological responses of guinea-pig myenteric neurons secondary to the release of endogenous serotonin by tryptamine, Neuroscience, 16, 223, 10.1016/0306-4522(85)90059-4
Takamura, 2010, Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice, Immunol. Cell Biol., 88, 685, 10.1038/icb.2010.35
Thaker, 2013, IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice, Gastroenterology, 145, 416.e414, 10.1053/j.gastro.2013.05.002
Théate, 2015, Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues, Cancer Immunol. Res., 3, 161, 10.1158/2326-6066.CIR-14-0137
Thorburn, 2014, Diet, metabolites, and “western-lifestyle” inflammatory diseases, Immunity, 40, 833, 10.1016/j.immuni.2014.05.014
Tilg, 2015, Food, immunity, and the microbiome, Gastroenterology, 148, 1107, 10.1053/j.gastro.2014.12.036
Tourino, 2013, Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells, Cell Biochem. Funct., 31, 361, 10.1002/cbf.2980
Turvill, 2000, The inhibition of cholera toxin-induced 5-HT release by the 5-HT(3) receptor antagonist, granisetron, in the rat, Br. J. Pharmacol., 130, 1031, 10.1038/sj.bjp.0703414
Uronis, 2009, Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility, PLoS ONE, 4, e6026, 10.1371/journal.pone.0006026
Uyttenhove, 2003, Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase, Nat. Med., 9, 1269, 10.1038/nm934
Valladares, 2013, Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats, FASEB J., 27, 1711, 10.1096/fj.12-223339
Van Beek, 2016, Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Delta7 mice, J. Leukoc. Biol, 101, 811, 10.1189/jlb.1HI0216-062RR
Venkatesh, 2014, Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4, Immunity, 41, 296, 10.1016/j.immuni.2014.06.014
Vereecke, 2017, Spondyloarthropathies: ruminococcus on the horizon in arthritic disease, Nat. Rev. Rheumatol., 13, 574, 10.1038/nrrheum.2017.130
Vikström Bergander, 2012, Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases, Mol. Endocrinol., 26, 1542, 10.1210/me.2011-1351
Walczak, 2011, Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells, Scand. J. Gastroenterol., 46, 903, 10.3109/00365521.2011.579159
Wang, 2006, Kynurenic acid as a ligand for orphan G Protein-coupled Receptor GPR35, J. Biol. Chem., 281, 22021, 10.1074/jbc.M603503200
Wang, 2010, Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon, PLoS ONE, 5, e13607, 10.1371/journal.pone.0013607
Weinlich, 2007, Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients, Dermatology, 214, 8, 10.1159/000096906
Whitehead, 2008, Catabolic pathway for the production of skatole and indoleacetic acid by the acetogen Clostridium drakei, Clostridium scatologenes, and swine manure, Appl. Environ. Microbiol., 74, 1950, 10.1128/AEM.02458-07
Whiteside, 2006, Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention, Semin. Cancer Biol., 16, 3, 10.1016/j.semcancer.2005.07.008
Whitfield-Cargile, 2016, The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy, Gut Microbes, 7, 246, 10.1080/19490976.2016.1156827
Wikoff, 2009, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites, Proc. Natl. Acad. Sci. U.S.A., 106, 3698, 10.1073/pnas.0812874106
Williams, 2014, Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine, Cell Host Microbe, 16, 495, 10.1016/j.chom.2014.09.001
Wilson, 2017, The gut-brain axis in healthy females: lack of significant association between microbial composition and diversity with psychiatric measures, PLoS ONE, 12, e0170208, 10.1371/journal.pone.0170208
Wlodarska, 2015, An integrative view of microbiome-host interactions in inflammatory bowel diseases, Cell Host Microbe, 17, 577, 10.1016/j.chom.2015.04.008
Wlodarska, 2017, Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation, Cell Host Microbe, 22, 25.e26, 10.1016/j.chom.2017.06.007
Wolf, 2004, Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease, Clin. Immunol., 113, 47, 10.1016/j.clim.2004.05.004
Xavier, 2007, Unravelling the pathogenesis of inflammatory bowel disease, Nature, 448, 427, 10.1038/nature06005
Xu, 2017, Redox properties of tryptophan metabolism and the concept of tryptophan use in pregnancy, Int. J. Mol. Sci., 18, 1595, 10.3390/ijms18071595
Yano, 2015, Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis, Cell, 161, 264, 10.1016/j.cell.2015.02.047
Yokoyama, 1979, Microbial metabolites of tryptophan in the intestinal tract with special reference to skatole, Am. J. Clin. Nutr., 32, 173, 10.1093/ajcn/32.1.173
Yoshihara, 1977, Gas Chromatographic microdetermination of indole and skatole in gastrointestinal contents of domestic animals, Agric. Biol. Chem., 41, 2083
Zambetti, 2014, NLRPs, microbiota, and gut homeostasis: unravelling the connection, J. Pathol., 233, 321, 10.1002/path.4357
Zelante, 2014, Tryptophan feeding of the IDO1-AhR axis in host–microbial symbiosis, Front. Immunol., 5, 640, 10.3389/fimmu.2014.00640
Zelante, 2013, Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22, Immunity, 39, 372, 10.1016/j.immuni.2013.08.003
Zenewicz, 2013, IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic, J.Immunol., 190, 5306, 10.4049/jimmunol.1300016