Impact of reduced apolipoprotein A-I levels on pulmonary arterial hypertension

Hemnes, 2019, Human PAH is characterized by a pattern of lipid-related insulin resistance, JCI Insight, 4, 10.1172/jci.insight.123611 Dubroff, 2020, High geographic prevalence of pulmonary artery hypertension: associations with ethnicity, drug use, and altitude, Pulm Circ, 10, 10.1177/2045894019894534 Leopold, 2016, Molecular Mechanisms of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Int J Mol Sci, 17, 10.3390/ijms17050761 Huertas, 2014, Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay, 129, 1332 Li, 2021, Microenvironmental regulation of macrophage transcriptomic and metabolomic profiles in pulmonary hypertension, 12, 640718 Ferreira, 2021, Metabolic reprogramming in pulmonary arterial hypertension: is it a cancer-like disease?, Eur Heart J, 42, 10.1093/eurheartj/ehab724.3414 Liu, 2022, Metabolic reprogramming: A novel metabolic model for pulmonary hypertension, Frontiers in Cardiovascular Medicine, 9 Agrawal, 2020, Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism, 10, 1522 Pugh, 2010, Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man, Int J Clin Pract, 64, 5, 10.1111/j.1742-1241.2010.02523.x Jonas, 2019, Prognostic role of traditional cardiovascular risk factors in patients with idiopathic pulmonary arterial hypertension, Arch Med Sci : AMS, 15, 1397, 10.5114/aoms.2018.79242 Zhao, 2012, Serum high-density lipoprotein cholesterol levels as a prognostic indicator in patients with idiopathic pulmonary arterial hypertension, Am J Cardiol, 110, 433, 10.1016/j.amjcard.2012.03.042 Provencher, 2019, More Insights into the Association between RVX-208 and Pulmonary Arterial Hypertension Reply Provencher, Steeve; Boucherat, Olivier; Berger, Rolf MF; Goumans, Marie-Jose; Bonnet, Sebastien, Epigenetics, 11, 102 Jonas, 2019, HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension, Int J Mol Sci, 20, 10.3390/ijms20143514 Zamanian, 2009, Insulin resistance in pulmonary arterial hypertension, Eur Respir J, 33, 318, 10.1183/09031936.00000508 Barter, 2006, The rationale for using apoA-I as a clinical marker of cardiovascular risk, J Intern Med, 259, 447, 10.1111/j.1365-2796.2006.01647.x Georgila, 2019, Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer, Cancers, 11, 10.3390/cancers11081097 Rader, 2014, HDL and cardiovascular disease, 384, 618 Yu, 2022, Apolipoprotein A1 is associated with pulmonary vascular resistance and adverse clinical outcomes in patients with pulmonary hypertension secondary to heart failure, Pulm Circ, 12, 10.1002/pul2.12096 Svitlana, 2022, Apolipoprotein A1 Enhances Endothelial Cell Survival in an <em>In Vitro</em> Model of ALS, eneuro, 9 Sharma, 2014, Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p, Circulation, 130, 776, 10.1161/CIRCULATIONAHA.114.007405 Borgese, 2021, EmPHasis-10 as a measure of health-related quality of life in pulmonary arterial hypertension: data from PHAR, Eur Respir J, 57, 10.1183/13993003.00414-2020 Galiè, 2015, 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension, 73, 1127 Goldberg, 2014, MELD exceptions for portopulmonary hypertension: current policy and future implementation, 14, 2081 Hanson, 2020, Identifying molecular recognition features in intrinsically disordered regions of proteins by transfer learning, Bioinformatics, 36, 1107, 10.1093/bioinformatics/btz691 O’Shea, 2017, Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1, J Biol Chem, 292, 512, 10.1074/jbc.M116.753426 van der Lee, 2014, Classification of intrinsically disordered regions and proteins, Chem Rev, 114, 6589, 10.1021/cr400525m Berra, 2016, Pulmonary hypertension in the elderly: a different disease?, Breathe, 12, 43, 10.1183/20734735.003416 Jonas, 2019, HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension, Int J Mol Sci, 20, 10.3390/ijms20143514 Larsen, 2016, Usefulness of high-density lipoprotein cholesterol to predict survival in pulmonary arterial hypertension, Am J Cardiol, 118, 292, 10.1016/j.amjcard.2016.04.028 Pu, 2008, HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL, Med Hypotheses, 70, 338, 10.1016/j.mehy.2007.05.025 Jonas, 2019, HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension, Int J Mol Sci, 20, 3514, 10.3390/ijms20143514 Chistiakov, 2016, ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease, Lab Invest, 96, 708, 10.1038/labinvest.2016.56 Yuditskaya, 2009, Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease, Blood, 113, 1122, 10.1182/blood-2008-03-142604 Florens, 2019, Proteomic Characterization of High-Density Lipoprotein Particles from Non-Diabetic Hemodialysis Patients, Toxins (Basel), 11, 10.3390/toxins11110671 Cohn, 2003, Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolism, JLR (J Lipid Res), 44, 1976, 10.1194/jlr.M300209-JLR200 Yingchun, 2018, Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice, Lipids Health Dis, 17, 10.1186/s12944-018-0867-5 Cudaback, 2012, Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation, J Neuroinflammation, 9, 192, 10.1186/1742-2094-9-192 Gadhave, 2020, The dark side of Alzheimer’s disease: unstructured biology of proteins from the amyloid cascade signaling pathway, Cell Mol Life Sci, 77, 4163, 10.1007/s00018-019-03414-9 Heresi, 2010, Plasma levels of high-density lipoprotein cholesterol and outcomes in pulmonary arterial hypertension, 182, 661 Ito, 2020, High-Density Lipoprotein (HDL) Triglyceride and Oxidized HDL: New Lipid Biomarkers of Lipoprotein-Related Atherosclerotic Cardiovascular Disease, Antioxidants, 9, 10.3390/antiox9050362 Harbaum, 2019, Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension, Thorax, 74, 380, 10.1136/thoraxjnl-2018-212144 Heresi, 2010, Plasma levels of high-density lipoprotein cholesterol and outcomes in pulmonary arterial hypertension, Am J Respir Crit Care Med, 182, 661, 10.1164/rccm.201001-0007OC Indulekha, 2011, High sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6, and vascular cell adhesion molecule-1 levels in Asian Indians with metabolic syndrome and insulin resistance (CURES-105), J Diabetes Sci Technol, 5, 982, 10.1177/193229681100500421 Fu, 2010, Ectopic ATP synthase in endothelial cells: a novel cardiovascular therapeutic target, 16, 4074 Strahlhofer-Augsten, 2022, The Distinct Role of the HDL Receptor SR-BI in Cholesterol Homeostasis of Human Placental Arterial and Venous Endothelial Cells, Int J Mol Sci, 23 Ashby, 1998, Factors Influencing the Ability of HDL to Inhibit Expression of Vascular Cell Adhesion Molecule-1 in Endothelial Cells, Arterioscler Thromb Vasc Biol, 18, 1450, 10.1161/01.ATV.18.9.1450 Ito, 2020, High-density lipoprotein (HDL) triglyceride and oxidized HDL: new lipid biomarkers of lipoprotein-related atherosclerotic cardiovascular disease, 9, 362 He, 2013, Effects of cigarette smoking on HDL quantity and function: implications for atherosclerosis, 114, 2431 Chen, 2020, The role of macrophages in pulmonary hypertension: Pathogenesis and targeting, 88 Frid, 2006, Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage, lineage, 168, 659 Cheng, 2012, Apolipoprotein AI attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts, 7 Wang, 2003, A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I, 111, 99 Jeong, 2017, The Role of Macrophage Lipophagy in Reverse Cholesterol Transport, enm, 32, 41 De Jong, 2008, Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment, 62, 263