Impact of parametric imaging on contrast-enhanced ultrasound of breast cancer
Tóm tắt
To prospectively evaluate the usefulness of contrast-enhanced ultrasound (CEUS) using parametric imaging for breast cancer in a multicenter study. A total of 65 patients with breast cancer were included in this study. CEUS was performed, and still images on peak time (S), accumulated images (A) and parametric images (P) were generated from the raw data. Four blind reviewers ranked the best visible images as first place, and determined second and third place consecutively. We compared the average ranking of each image. The maximal diameter of the tumor determined on ultrasonography and MRI was compared with the corresponding pathological maximal diameter for 48 of the 65 patients. The correlation between the diameter determined by two experts and two beginners was analyzed. The average rank of visibility was as follows: P, 1.44; A, 2.04; and S, 2.52. The correlation between each image and the pathology was as follows: P, r = 0.664; A, r = 0.630; S, r = 0.717; and MRI, r = 0.936. There were no significant differences among the correlation between the experts and beginners in each image. The use of parametric imaging improves the visibility of CEUS. The maximal diameter of the tumor determined on CEUS correlates substantially with the pathology.
Tài liệu tham khảo
Miyamoto Y, Ito T, Takada E, et al. Efficacy of sonazoid (Perflubutane) for contrast-enhanced ultrasound in the differentiation of focal breast lesions: phase 3 multicenter clinical trial. AJR. 2014;202:W400–7.
Du J, Wang L, Wan CF, et al. Differentiating benign from malignant solid breast lesions; combined utility of conventional ultrasound and contrast-enhanced ultrasound in comparison with magnetic resonance imaging. Eur J Radiol. 2012;81:3890–9.
van Esser S, Veldhuis WB, van Hillegersberg R, et al. Accuracy of contrast-enhanced breast ultrasound for pre-operative tumor size assessment in patients diagnosed with invasive ductal carcinoma of the breast. Cancer Imaging. 2007;7:63–8.
Jiang YX, Liu H, Liu JB, et al. Breast tumor size assessment: comparison of conventional ultrasound and contrast-enhanced ultrasound. Ultrasound Med Bio. 2007;33:1873–81.
Fujisawa T, Hirakata T, Yanagita Y, et al. The detection of pCR after PST by contrast-enhanced ultrasonography for breast cancer. Breast Cancer. 2013;20:75–82.
Corcioni B, Santilli L, Quercia S, et al. Contrast-enhanced US and MRI for assessing the response of breast cancer to neoadjuvant chemotherapy. J Ultrasound. 2008;11:143–50.
Boes JL, Hoff BA, Hylton N, et al. Image registration for quantitative parametric response mapping of cancer treatment response. Transl Oncol. 2014;7:101–10.
Wakui N, Takayama R, Kamiyama N, et al. Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm. Exp Ther Med. 2013;5:1551–4.
Wakui N, Sumino Y, Kamiyama N. A case of high-flow hepatic hemangioma:analysis by parametoric imaging using sonazoid-enhanced ultrasonography. J Med Ultrasonics. 2010;37:87–90.
Shiozawa K, Watanabe M, Takayama R, et al. Hepatic parenchymal hemodynamics of cholangitis with portal trunk thrombus using contrast-enhanced ultrasonography with Sonazoid: delineation of so-called central and peripheral zonal differentiation by arrival-time parametric imaging. J Med Ultrasonics. 2013;40:73–6.
Wakui N, Takayama R, Matsukiyo Y, et al. Arrival time parametric imaging of the hemodynamic balance changes between the hepatic artery and the portal vein during deep inspiration, using Sonazoid-enhanced ultrasonography: a case of Budd-Chiari syndrome. Exp Ther Med. 2013;6:15–21.
Zhao H, Xu R, Ouyang Q, et al. Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions. Eur J Radiol. 2010;73:288–93.
Yuan Z, Quan J, Yunxiao Z, et al. Diagnostic value of contrast-enhanced ultrasound parametric imaging in breast tumors. J Breast Cancer. 2013;16:208–13.
Houssami N, Ciatto S, Macaskill P, et al. Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer. J Clin Oncol. 2008;26:3248–58.
Boetes C, Mus RD, Holland R, et al. Breast tumors: comparative accuracy of MR imaging relative to mammography and US for demonstrating extent. Radiology. 1995;197:743–7.
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.
Balleyguier C, Opolon P, Mathieu MC, et al. New potential and applications of contrast-enhanced ultrasound of the breast: own investigations and review of the literature. Eur J Radiol. 2009;69:14–23.