Immunotargeting of insulin reactive CD8 T cells to prevent Diabetes

Journal of Autoimmunity - Tập 35 - Trang 390-397 - 2010
Gwen S. Scott1, Sigal Fishman2, L. Khai Siew1, Alon Margalit2,3, Stephen Chapman1, Alexander V. Chervonsky4, Li Wen5, Gideon Gross2,3, F. Susan Wong1
1Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
2Laboratory of Immunology, MIGAL-Galilee Technology Center, Kiryat Shmona, Israel
3Department of Biotechnology, Tel-Hai Academic College, Upper Galilee, Israel
4Department of Pathology, University of Chicago, Chicago, IL 60637 USA
5Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520, USA

Tài liệu tham khảo

Wong, 1999, Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library, Nat Med, 5, 1026, 10.1038/12465 Lieberman, 2003, Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes, Proc Natl Acad Sci U S A, 100, 8384, 10.1073/pnas.0932778100 Lieberman, 2004, Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase, J Immunol, 173, 6727, 10.4049/jimmunol.173.11.6727 Quinn, 2001, MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity, J Immunol, 167, 1748, 10.4049/jimmunol.167.3.1748 Nakayama, 2005, Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice, Nature, 435, 220, 10.1038/nature03523 Jyothi, 2002, Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes, Nat Biotechnol, 20, 1215, 10.1038/nbt758 Margalit, 2003, Chimeric beta2 microglobulin/CD3zeta polypeptides expressed in T cells convert MHC class I peptide ligands into T cell activation receptors: a potential tool for specific targeting of pathogenic CD8(+) T cells, Int Immunol, 15, 1379, 10.1093/intimm/dxg136 Mitsuyasu, 2000, Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects, Blood, 96, 785, 10.1182/blood.V96.3.785 Nguyen, 2003, Antigen-specific targeting of CD8+ T cells with receptor-modified T lymphocytes, Gene Ther, 10, 594, 10.1038/sj.gt.3301932 Wong, 1996, CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells, J Exp Med, 183, 67, 10.1084/jem.183.1.67 Wong, 2009, Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes, Diabetes, 58, 1156, 10.2337/db08-0800 Wong, 2002, Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus, Proc Natl Acad Sci U S A, 99, 5551, 10.1073/pnas.072037299 Lee-MacAry, 2001, Development of a novel flow cytometric cell-mediated cytotoxicity assay using the fluorophores PKH-26 and TO-PRO-3 iodide, J Immunol Methods, 252, 83, 10.1016/S0022-1759(01)00336-2 Thomas, 2007, CD86 has sustained costimulatory effects on CD8 T cells, J Immunol, 179, 5936, 10.4049/jimmunol.179.9.5936 Kataoka, 1994, Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity, J Immunol, 153, 3938, 10.4049/jimmunol.153.9.3938 Trudeau, 2003, Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood, J Clin Invest, 111, 217, 10.1172/JCI200316409 Krishnamurthy, 2006, Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP, J Clin Invest, 116, 3258, 10.1172/JCI29602 Brodie, 2008, B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes, Diabetes, 57, 909, 10.2337/db07-1256 Serreze, 1994, Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant, Diabetes, 43, 505, 10.2337/diabetes.43.3.505 Wicker, 1994, Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes, Diabetes, 43, 500, 10.2337/diabetes.43.3.500 Wang, 1996, The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus, Eur J Immunol, 26, 1762, 10.1002/eji.1830260815 Amrani, 2000, Progression of autoimmune diabetes driven by avidity maturation of a T-cell population, Nature, 406, 739, 10.1038/35021081 Toma, 2005, Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients, Proc Natl Acad Sci U S A, 102, 10581, 10.1073/pnas.0504230102 Hassainya, 2005, Identification of naturally processed HLA-A2–restricted proinsulin epitopes by reverse immunology, Diabetes, 54, 2053, 10.2337/diabetes.54.7.2053 Mallone, 2007, CD8+ T-cell responses identify {beta}-cell autoimmunity in human type 1 diabetes, Diabetes, 56, 613, 10.2337/db06-1419 Baker, 2008, Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery, J Clin Immunol, 10.1007/s10875-008-9177-4 Skowera, 2008, CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope, J Clin Invest, 118, 3390 Ou, 1999, CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility, Hum Immunol, 60, 652, 10.1016/S0198-8859(99)00037-3 Panina-Bordignon, 1995, Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes, J Exp Med, 181, 1923, 10.1084/jem.181.5.1923 Ouyang, 2006, Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes, Diabetes, 55, 3068, 10.2337/db06-0065 Panagiotopoulos, 2003, Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes, Diabetes, 52, 2647, 10.2337/diabetes.52.11.2647 Standifer, 2006, Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives, Diabetes, 55, 3061, 10.2337/db06-0066