Immunopathogenesis of allergic bronchopulmonary aspergillosis in cystic fibrosis

Knutsen, 1998, Cell-mediated immunity in allergic bronchopulmonary aspergillosis, Immunol Allergy Clin N Am, 18, 575, 10.1016/S0889-8561(05)70023-0 Patterson, 1986, Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies, Arch Intern Med, 146, 916, 10.1001/archinte.1986.00360170130020 Schwartz, 1991, The prevalence of allergic bronchopulmonary aspergillosis in patients with asthma, determined by serologic and radiologic criteria in patients at risk, J Lab Clin Med, 117, 138 Krasnick, 1995, Allergic bronchopulmonary aspergillosis: serologic update for 1995, J Clin Lab Immunol, 46, 137 Greenberger, 1994, Diagnosis and management of allergic bronchopulmonary aspergillosis, Allergy Proc, 15, 335, 10.2500/108854194778816463 Nelson, 1979, Aspergillosis and atopy in cystic fibrosis, Am Rev Respir Dis, 120, 863 Laufer, 1984, Allergic bronchopulmonary aspergillosis in cystic fibrosis, J Allergy Clin Immunol, 73, 44, 10.1016/0091-6749(84)90482-2 Zeaske, 1988, Immune responses to Aspergillus in cystic fibrosis, J Allergy Clin Immunol, 82, 73, 10.1016/0091-6749(88)90054-1 Valletta, 1993, Sensitization to Aspergillus and allergic bronchopulmonary aspergillosis in a cystic fibrosis population, Pediatr Asthma Allergy Immunol, 7, 43, 10.1089/pai.1993.7.43 el-Dhar, 1994, Development of immune responses to Aspergillus at an early age in children with cystic fibrosis, Am J Respir Crit Care Med, 150, 1513, 10.1164/ajrccm.150.6.7952609 Wojnarowski, 1997, Sensitization to Aspergillus fumigatus and lung function in children with cystic fibrosis, Am J Respir Crit Care Med, 155, 1902, 10.1164/ajrccm.155.6.9196093 Knutsen, 1990, Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis, Clin Rev Allergy, 9, 103, 10.1007/BF02914537 Knutsen, 1992, Allergic bronchopulmonary mycosis complicating cystic fibrosis, Sem Respir Infect, 7, 179 Hutcheson, 1991, Variability in immune parameters of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis, J Allergy Clin Immunol, 88, 390, 10.1016/0091-6749(91)90102-T Hutcheson, 1996, A twelve-year longitudinal study of Aspergillus sensitivity in cystic fibrosis patients, Chest, 110, 363, 10.1378/chest.110.2.363 Becker, 1996, Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis, Chest, 109, 1536, 10.1378/chest.109.6.1536 Slavin, 1988, A pathologic study of allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 81, 718, 10.1016/0091-6749(88)91044-5 Paris, 1997, Internalization of Aspergillus fumigatus conidia by epithelial and endothelial cells, Infect Immunol, 65, 1510, 10.1128/IAI.65.4.1510-1514.1997 Kurup, 1994, Particulate Aspergillus fumigatus antigens elicit a TH2 response in BALB/c mice, J Allergy Clin Immunol, 93, 1013, 10.1016/S0091-6749(94)70050-8 Kauffman, 1999, Inflammatory cells and airway defense against Aspergillus fumigatus, Immunol Allergy Clin N Am, 18, 619, 10.1016/S0889-8561(05)70025-4 Tomee, 2000, Putative virulence factors of Aspergillus fumigatus, Clin Exp Allergy, 30, 476, 10.1046/j.1365-2222.2000.00796.x Tomee, 1994, Immunologic significance of a collagen-derived culture filtrate containing proteolytic activity in Aspergillus-related diseases, J Allergy Clin Immunol, 93, 768, 10.1016/0091-6749(94)90257-7 Tomee, 1995, Serologic monitoring of disease and treatment in a patient with pulmonary aspergilloma, Am J Respir Crit Care Med, 151, 199, 10.1164/ajrccm.151.1.7812553 Robinson, 1990, Allergens as proteases: an Aspergillus fumigatus proteinase directly induces human epithelial cell detachment, J Allergy Clin Immunol, 86, 726, 10.1016/S0091-6749(05)80176-9 Tomee, 1997, Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines, J Infect Dis, 176, 300, 10.1086/517272 Kauffman, 2000, Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production, J Allergy Clin Immunol, 105, 1185, 10.1067/mai.2000.106210 Herbert, 1995, Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1, Am J Respir Cell Mol Biol, 12, 369, 10.1165/ajrcmb.12.4.7695916 Persson, 1996, Epithelial shedding–restitution as a causative process in airway inflammation, Clin Exp Allergy, 26, 746, 10.1111/j.1365-2222.1996.tb00604.x Knutsen, 1989, In vitro T-cell responses in cystic fibrosis patients with allergic bronchopulmonary aspergillosis, J Lab Clin Med, 113, 428 Slavin, 1987, Participation of cell-mediated immunity in allergic bronchopulmonary aspergillosis, Int Arch Allergy Appl Immunol, 83, 337, 10.1159/000234365 Murali, 1994, Immune responses to Aspergillus fumigatus and Pseudomonas aeruginosa antigens in cystic fibrosis and allergic bronchopulmonary aspergillosis, Chest, 106, 513, 10.1378/chest.106.2.513 Kurup, 1985, Serum antibodies and their role in antibody-dependent cell-mediated cytotoxicity in aspergillosis, Immunobiology, 169, 362, 10.1016/S0171-2985(85)80017-6 Knutsen, 1990, T- and B-cell dysregulation of IgE synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis, Clin Immunol Immunopathol, 55, 129, 10.1016/0090-1229(90)90074-Z Knutsen, 1994, Characterization of Asp f1 CD4+ T-cell lines in allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 94, 215, 10.1053/ai.1994.v94.a54891 Chauhan, 1996, T-cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis, J Clin Invest, 97, 2324, 10.1172/JCI118675 Chauhan, 1997, The association of HLA-DR alleles and T-cell activation with allergic bronchopulmonary aspergillosis, J Immunol, 159, 4072, 10.4049/jimmunol.159.8.4072 Kotsimbos, 1998, Expression of the IL-4 receptor α-subunit is increased in bronchial biopsy specimens from atopic and non-atopic asthmatic subjects, J Allergy Clin Immunol, 102, 859, 10.1016/S0091-6749(98)70029-6 Yanagihara, 1995, Functional significance of IL-4 receptor on B-cells in IL-4-induced human IgE production, J Allergy Clin Immunol, 96, 1145, 10.1016/S0091-6749(95)70199-0 Harada, 1998, Identification of the critical portions of the human IL-4 receptor α chain for activation of STAT6, Biochem Biophys Res Commun, 246, 675, 10.1006/bbrc.1998.8696 Hershey, 1997, The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor, N Engl J Med, 337, 1720, 10.1056/NEJM199712113372403 Ryan, 1997, Interleukin-4 and its receptor: essential mediators of the allergic response, J Allergy Clin Immunol, 99, 1 Izuhara, 2000, Atopy and the human IL-4 receptor α chain, J Allergy Clin Immunol, 106, S65, 10.1067/mai.2000.106776 Romagnani, 2000, The role of lymphocytes in allergic diseases, J Allergy Clin Immunol, 105, 399, 10.1067/mai.2000.104575 Durham, 2000, T lymphocytes in asthma: bronchial versus peripheral response, J Allergy Clin Immunol, 106, S221, 10.1067/mai.2000.110154 Hamid, 2000, Recruitment of T-cells to the lung in response to antigen challenge, J Allergy Clin Immunol, 106, S227, 10.1067/mai.2000.110161 Bacharier, 2000, Molecular mechanisms of IgE regulation, J Allergy Clin Immunol, 105, S547, 10.1016/S0091-6749(00)90059-9 Oettgen, 2001, Molecular mechanisms in allergy and clinical immunology, J Allergy Clin Immunol, 107, 429, 10.1067/mai.2001.113759 Leonard, 2000, Cytokine receptor signaling pathways, J Allergy Clin Immunol, 105, 877, 10.1067/mai.2000.106899 Jeannin, 1997, CD86 (B7-2) on human B-cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells, J Biol Chem, 272, 15613, 10.1074/jbc.272.25.15613 Nakajima, 1997, Requirement of CD28–CD86 co-stimulation in the interaction between antigen-primed T helper type-2 and B-cells, Int Immunol, 9, 637, 10.1093/intimm/9.5.637 Jirapongsananuruk, 1998, Enhanced expression of B7.2 (CD86) in patients with atopic dermatitis: a potential role in the modulation of IgE synthesis, J Immunol, 160, 4622, 10.4049/jimmunol.160.9.4622 Haczku, 1999, Anti-CD86 (B7.2) treatment abolishes allergic airway hyperresponsiveness in mice, Am J Respir Crit Care Med, 159, 1638, 10.1164/ajrccm.159.5.9711040 Jiang, 1998, Role of CD86 (B7-2) in triggering of antigen-specific IgE antibody response by lipopolysaccharide, REMS Immunol Med Microbiol, 21, 303, 10.1111/j.1574-695X.1998.tb01178.x Huang, 1998, The involvement of CD80 and CD86 costimulatory molecules in the induction of eosinophilia in mice infected with Nippostrongylus brasiliensis, Int Arch Allergy Immunol, 117, 2, 10.1159/000053561 Tsuyuki, 1997, Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T-helper cell 2 (TH2) immune response and altered airway responsiveness, J Exp Med, 185, 1671, 10.1084/jem.185.9.1671 Nakada, 1999, CD80 (B7-1) and CD86 (B7-2) antigens on house dust mite-specific T-cells in atopic disease function through T–T interactions, J Allergy Clin Immunol, 104, 222, 10.1016/S0091-6749(99)70139-9 Gause, 1999, The development of CD4+ T-effector cells during the type-2 immune response, Immunol Res, 20, 55, 10.1007/BF02786507 Jirapongsananuruk, 1999, The modulation of B7.2 and B7.1 on B-cells by immunosuppressive agents, Clin Exp Immunol, 118, 1, 10.1046/j.1365-2249.1999.01028.x Reljic, 1997, Function of CD23 in the response of human B-cells to antigen, Eur J Immunol, 27, 572, 10.1002/eji.1830270232 Challa, 1999, Epitope-dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B-cells, Allergy, 54, 576, 10.1034/j.1398-9995.1999.00092.x Bonnefoy, 1995, Regulation of IgE synthesis by CD23/CD21 interaction, Int Arch Allergy Immunol, 107, 40, 10.1159/000236924 Yoshimoto, 1845, Role of NK1.1+ T-cells in a Th2 response and in immunoglobulin E production, Science :-1847,m, 270, 1995 Bonnefoy, 1996, Pairs of surface molecules involved in human IgE regulation: CD23–CD21 and CD40–CD40L, Eur Respir J, 22, 63s Armant, 1995, Soluble CD23 directly activates monocytes to contribute to the antigen-independent stimulation of resting T-cells, J Immunol, 155, 4868, 10.4049/jimmunol.155.10.4868 Khan, 2000, Increased sensitivity to IL-4 in patients with allergic bronchopulmonary aspergillosis and atopy, Int Arch Allergy Immunol, 123, 319, 10.1159/000053644 Knutsen AP, Hutcheson PS, Smick J, Kurup PS. Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol, submitted for publication. Crameri, 1998, Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis, Int Immunol, 10, 1211, 10.1093/intimm/10.8.1211 Hemmann, 1998, Differential IgE recognition of recombinant Aspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis, Eur J Immunol, 28, 1155, 10.1002/(SICI)1521-4141(199804)28:04<1155::AID-IMMU1155>3.0.CO;2-6 Hemmann, 1998, Skin-test reactivity and isotype-specific immune responses to recombinant Asp f3, a major allergen of Aspergillus fumigatus, Clin Exp Allergy, 28, 860, 10.1046/j.1365-2222.1998.00329.x Banerjee, 1997, Purification of a major allergen, Asp f2 binding to IgE in allergic bronchopulmonary aspergillosis, from culture filtrate of Aspergillus fumigatus, J Allergy Clin Immunol, 99, 821, 10.1016/S0091-6749(97)80017-6 Banerjee, 1998, Immunological characterization of Asp f2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis, Infect Immun, 66, 5175, 10.1128/IAI.66.11.5175-5182.1998 Murali, 1997, Exposure to Aspergillus spores elicits allergic responses similar to soluble antigens in a model of allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 99, S353 Walker, 1991, Activated T-cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease activity, J Allergy Clin Immunol, 88, 935, 10.1016/0091-6749(91)90251-I Bochner, 2000, Systemic activation of basophils and eosinophils: markers and consequences, J Allergy Clin Immunol, 106, S292, 10.1067/mai.2000.110164 Slavin, 1988, A pathologic study of allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 81, 718, 10.1016/0091-6749(88)91044-5 Knutsen, 1990, Serum IgE and IgG anti-Aspergillus fumigatus antibody in cystic fibrosis patients with allergic bronchopulmonary aspergillosis, J Lab Clin Med, 116, 724 Greenberger, 1983, Application of enzyme-linked immunosorbent assay (ELISA) in diagnosis of allergic bronchopulmonary aspergillosis, J Lab Clin Med, 99, 288 Brummund, 1987, Aspergillus fumigatus-specific antibodies in allergic bronchopulmonary aspergillosis and aspergilloma: evidence for a polyclonal antibody response, J Clin Microbiol, 25, 5, 10.1128/JCM.25.1.5-9.1987 Tomee, 1952, Specific IgG4 responses during chronic and transient antigen exposure in aspergillosis, Am J Respir Crit Care Med :-1957, 153, 1996 Edwards, 1990, Sequential serological responses to Aspergillus fumigatus in patients with cystic fibrosis. Use of antigen ‘stretching’ to delineate IgG and IgE activity, Clin Exp Immunol, 81, 101, 10.1111/j.1365-2249.1990.tb05298.x Patterson, 1980, IgA antibody against Aspergillus fumigatus antigen in patients with allergic bronchopulmonary aspergillosis, Clin Exp Immunol, 42, 395 Gutt, 1986, Serum IgA antibodies to Aspergillus fumigatus in various stages of allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 78, 98, 10.1016/0091-6749(86)90120-X Bernstein, 1990, Immunoblot analysis of sera from patients with allergic bronchopulmonary aspergillosis: correlation with disease activity, J Allergy Clin Immunol, 86, 532, 10.1016/S0091-6749(05)80209-X Trompelt, 1994, Analysis of IgG subclass and IgE response in allergic disease caused by Aspergillus fumigatus by immunoblotting techniques, Int Arch Allergy Immunol, 104, 390, 10.1159/000236697 Leser, 1992, Specific serum immunopatterns in clinical phases of allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 90, 589, 10.1016/0091-6749(92)90131-K Knutsen, 1994, Serum anti-Aspergillus fumigatus antibodies by immunoblot and ELISA in cystic fibrosis with allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 93, 926, 10.1016/0091-6749(94)90387-5 Kurup, 1989, Antibody response to low-molecular-weight antigens of Aspergillus fumigatus in allergic bronchopulmonary aspergillosis, J Clin Microbiol, 27, 1312, 10.1128/JCM.27.6.1312-1316.1989 Lopez-Medrano, 1996, Immunoblotting patterns in the serodiagnosis of aspergilloma: antibody response to the 90-kDa Aspergillus fumigatus antigen, Eur J Clin Microbiol Infect Dis, 15, 146, 10.1007/BF01591488 Slavin, 1992, Localization of IgE to lung germinal lymphoid follicles in a patient with allergic bronchopulmonary aspergillosis, J Allergy Clin Immunol, 90, 1006, 10.1016/0091-6749(92)90479-L Nelms, 1999, The IL-4 receptor: signalling mechanisms and biologic functions, Annu Rev Immunol, 17, 701, 10.1146/annurev.immunol.17.1.701 Ober, 2000, Variation in the interleukin 4-receptor α gene confers susceptibility to asthma and atopy in ethnically diverse populations, Am J Hum Genet, 66, 517, 10.1086/302781 Alam, 1997, Chemokines in allergic inflammation, J Allergy Clin Immunol, 99, 273, 10.1016/S0091-6749(97)70042-3 Ricketti, 1983, Hyperreactivity of mediator-releasing cells from patients with allergic bronchopulmonary aspergillosis as evidenced by basophil histamine release, J Allergy Clin Immunol, 72, 386, 10.1016/0091-6749(83)90504-3 Kita, 1996, The eosinophil: a cytokine-producing cell, J Allergy Clin Immunol, 97, 889, 10.1016/S0091-6749(96)80061-3 Gleich, 1988, The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperactivity, J Allergy Clin Immunol, 81, 776, 10.1016/0091-6749(88)90931-1 Yamaguchi, 1990, Role of IL-5 in IL-2-induced eosinophilia: in vivo and in vitro expression of IL-5 mRNA by IL-2, J Immunol, 145, 873, 10.4049/jimmunol.145.3.873 Gaga, 1991, Eosinophil activation and T lymphocyte infiltration in allergen-induced late-phase skin reactions and classical delayed-type hypersensitivity, J Immunol, 147, 816, 10.4049/jimmunol.147.3.816 Bagley, 1997, New frontiers for IL-5, J Allergy Clin Immunol, 99, 725, 10.1016/S0091-6749(97)80002-4 Heath, 1997, Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody, J Clin Invest, 99, 178, 10.1172/JCI119145 Sallusto, 1997, Selective expression of the eotaxin receptor CCR3 by human T helper cells, Science, 277, 2005, 10.1126/science.277.5334.2005 Sur, 1993, Eosinophils: biochemical and cellular aspects, 169 Ying, 1997, Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T-cells in allergen-induced late-phase cutaneous reactions in atopic subjects, J Immunol, 158, 5050, 10.4049/jimmunol.158.10.5050 Bracke, 1997, Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors expressed by human eosinophils, J Immunol, 159, 1459, 10.4049/jimmunol.159.3.1459 Cromwell, 1988, Leukotriene C4 generation from human eosinophils stimulated with IgG–Aspergillus fumigatus antigen immune complexes, J Allergy Clin Immunol, 82, 535, 10.1016/0091-6749(88)90962-1 O'Hehir, 1989, An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of an atopic and a non-atopic individual to Dermatophagoides spp. (house dust mite), Immunology, 66, 499 Higgins, 1994, Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules, J Allergy Clin Immunol, 93, 891, 10.1016/0091-6749(94)90383-2 O'Hehir, 1993, Analysis of human T-cell responses to the group II allergen of Dermatophagoides species: localization of major antigenic sites, J Allergy Clin Immunol, 92, 105, 10.1016/0091-6749(93)90044-G Jarman, 1994, Inhibition of human T-cell responses to house dust mite allergens by a T-cell receptor peptide, J Allergy Clin Immunol, 94, 844, 10.1016/0091-6749(94)90152-X Wedderburn, 1993, In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens, Proc Natl Acad Sci USA, 90, 8214, 10.1073/pnas.90.17.8214 Verhoef, 1993, Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T-cell epitopes, Int Immunol, 5, 1589, 10.1093/intimm/5.12.1589 Lamb, 1995, The effects of changes at peptide residues contacting MHC class II T-cell receptor on antigen recognition and human Th0 cell effector function, Immunology, 85, 447 Tsitoura, 1996, Altered T-cell ligands derived from a major house dust mite allergen enhance IFN-γ but not IL-4 production by human CD4+ T-cells, J Immunol, 157, 2160, 10.4049/jimmunol.157.5.2160 Pfeiffer, 1995, Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo, J Exp Med, 181, 1569, 10.1084/jem.181.4.1569 Evavold, 1993, Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides, J Immunol, 150, 3131, 10.4049/jimmunol.150.8.3131 Racioppi, 1993, Peptide–major histocompatibility complex class II complexes with agonist/antagonist properties provide evidence for ligand-related differences in T-cell receptor-dependent intracellular signaling, J Exp Med, 177, 1047, 10.1084/jem.177.4.1047 Miller, 1996, Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in allergic bronchopulmonary aspergillosis, Am J Hum Genet, 59, 45