Immunomodulation by tramadol combined with acetaminophen or dexketoprofen: In vivo animal study

Yong, 2017, Mononuclear Phagocytes as a Target, Not a Barrier, for Drug Delivery, J. Control. Release, 259, 53, 10.1016/j.jconrel.2017.01.024 Nazimek, 2015, The role of medicaments, exosomes and miRNA molecules in modulation of macrophage immune activity, Postepy. Hig. Med. Dosw. (Online), 69, 1114 Fornasari, 2017, A “Novel” Association to Treat Pain: Tramadol/Dexketoprofen. The First Drug of a “New Pharmacological Class”, Acta Biomed., 88, 17 Kuczyńska, 2022, The Comparison of Dexketoprofen and Other Painkilling Medications (Review from 2018 to 2021), Biomed. Pharmacother., 149, 10.1016/j.biopha.2022.112819 Raffa, 2010, The Determination and Application of Fixed-Dose Analgesic Combinations for Treating Multimodal Pain, J. Pain, 11, 701, 10.1016/j.jpain.2009.12.010 Kozlowski, 2019, Analgesic Adjuvants Modulate Morphine-Induced Immune Effects in Mice, Pharmacol. Rep., 71, 573, 10.1016/j.pharep.2019.04.016 Kozlowski, 2017, The Impact of Advanced Opioid Drugs and Analgesic Adjuvants on Murine Macrophage Oxygen Burst, Folia Med. Cracov., 57, 15 Bodnar, 2022, Endogenous Opiates and Behavior: 2020, Peptides, 151, 10.1016/j.peptides.2022.170752 Janjic, 2018, Low-Dose NSAIDs Reduce Pain via Macrophage Targeted Nanoemulsion Delivery to Neuroinflammation of the Sciatic Nerve in Rat, J Neuroimmunol, 318, 72, 10.1016/j.jneuroim.2018.02.010 V. Malafoglia S. Ilari L. Vitiello M. Tenti E. Balzani C. Muscoli W. Raffaeli A. Bonci The Interplay between Chronic Pain, Opioids, and the Immune System Neuroscientist (2021) 107385842110304, doi:10.1177/10738584211030493. Mefford, 2021, The Immunomodulatory Effects of Opioids and Implications for Intensive Care Unit Populations, Pharmacotherapy, 41, 668, 10.1002/phar.2602 Wen, 2021, Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles, Front. Pharmacol., 12 Nguyen, 2021, Diverse Roles of TRPV4 in Macrophages: A Need for Unbiased Profiling, Front. Immunol., 12 Przybyła, 2020, Paracetamol - An Old Drug with New Mechanisms of Action, Clin. Exp. Pharmacol. Physiol. Baker, 1999, Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes with Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages, Arterioscler. Thromb. Vasc. Biol., 19, 646, 10.1161/01.ATV.19.3.646 Mayoral Rojals, 2022, New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review, Cureus, 14, e23037 Czajkowska, 1995, Different Isoenzyme Patterns of Nonspecific Esterases and the Level of IL6 Production as Markers of Macrophage Functions, Folia Histochem. Cytobiol., 33, 111 Marzinzig, 1997, Improved Methods to Measure End Products of Nitric Oxide in Biological Fluids: Nitrite, Nitrate, and S-Nitrosothiols, Nitric Oxide, 1, 177, 10.1006/niox.1997.0116 Filipczak-Bryniarska, 2018, Data Supporting the Understanding of Modulatory Function of Opioid Analgesics in Mouse Macrophage Activity, Data Brief, 16, 950, 10.1016/j.dib.2017.12.017 Filipczak-Bryniarska, 2012, The Influence of Opioids on the Humoral and Cell-Mediated Immune Responses in Mice. The Role of Macrophages, Pharmacol. Rep., 64, 1200, 10.1016/S1734-1140(12)70916-7 Filipczak-Bryniarska, 2018, In Contrast to Morphine, Buprenorphine Enhances Macrophage-Induced Humoral Immunity and as Oxycodone, Slightly Suppresses the Effector Phase of Cell-Mediated Immune Response in Mice, Int. Immunopharmacol., 54, 344, 10.1016/j.intimp.2017.11.039 Nazimek, 2016, Repeatedly Administered Antidepressant Drugs Modulate Humoral and Cellular Immune Response in Mice through Action on Macrophages, Exp. Biol. Med. (Maywood), 241, 1540, 10.1177/1535370216643769 Ghosn, 2010, Two Physically, Functionally, and Developmentally Distinct Peritoneal Macrophage Subsets, Proc. Natl. Acad. Sci. USA, 107, 2568, 10.1073/pnas.0915000107 Cho, 2010, Licochalcone E Reduces Chronic Allergic Contact Dermatitis and Inhibits IL-12p40 Production through down-Regulation of NF-ΚB, Int. Immunopharmacol., 10, 1119, 10.1016/j.intimp.2010.06.015 A. dos A Cassado, M.R. D’Império Lima, K.R. Bortoluci, Revisiting Mouse Peritoneal Macrophages: Heterogeneity, Development, and Function, Front. Immunol. 6 (2015), doi: 10.3389/fimmu.2015.00225. García-Peñarrubia, 2021, Recent Insights into the Characteristics and Role of Peritoneal Macrophages from Ascites of Cirrhotic Patients, World J. Gastroenterol., 27, 7014, 10.3748/wjg.v27.i41.7014 Ruiz-Alcaraz, 2018, Characterization of Human Peritoneal Monocyte/Macrophage Subsets in Homeostasis: Phenotype, GATA6, Phagocytic/Oxidative Activities and Cytokines Expression, Sci. Rep., 8, 12794, 10.1038/s41598-018-30787-x Chen, 2022, Identification of Macrophages in Normal and Injured Mouse Tissues Using Reporter Lines and Antibodies, Sci. Rep., 12, 4542, 10.1038/s41598-022-08278-x Takenaka, 2018, Selective DNAM-1 Expression on Small Peritoneal Macrophages Contributes to CD4+ T Cell Costimulation, Sci. Rep., 8, 15180, 10.1038/s41598-018-33437-4 Duan, 2016, CD11b Immunophenotyping Identifies Inflammatory Profiles in the Mouse and Human Lungs, Mucosal Immunol., 9, 550, 10.1038/mi.2015.84 Schmid, 2018, Integrin CD11b Activation Drives Anti-Tumor Innate Immunity, Nat. Commun., 9, 5379, 10.1038/s41467-018-07387-4 Min, 2013, Stimulation of CD107 Affects LPS-Induced Cytokine Secretion and Cellular Adhesion through the ERK Signaling Pathway in the Human Macrophage-like Cell Line, THP-1, CellImmunol, 281, 122 Zhou, 2005, Lamp-2a Facilitates MHC Class II Presentation of Cytoplasmic Antigens, Immunity, 22, 571, 10.1016/j.immuni.2005.03.009 Chistiakov, 2017, CD68/Macrosialin: Not Just a Histochemical Marker, Lab. Invest., 97, 4, 10.1038/labinvest.2016.116 Zhang, 2017, Tramadol Differentially Regulates M1 and M2 Macrophages from Human Umbilical Cord Blood, Inflammopharmacology, 10.1007/s10787-017-0338-z Yowtak, 2011, Reactive Oxygen Species Contribute to Neuropathic Pain by Reducing Spinal GABA Release, Pain, 152, 844, 10.1016/j.pain.2010.12.034 Karaaslan, 2006, The Role of Nitric Oxide on the Analgesic Effect of Tramadol, The Pain Clinic, 18, 123, 10.1163/156856906776760498 Lesani, 2010, Involvement of the Nitric Oxide Pathway in the Anticonvulsant Effect of Tramadol on Pentylenetetrazole-Induced Seizures in Mice, EpilepsyBehav, 19, 290 Beilin, 2005, Tramadol Does Not Impair the Phagocytic Capacity of Human Peripheral Blood Cells, Can. J. Anesth/J. Can. Anesth., 52, 1035, 10.1007/BF03021601 Shirzad, 2009, Comparison of Morphine and Tramadol Effects on Phagocytic Activity of Mice Peritoneal Phagocytes in Vivo, Int. Immunopharmacol., 9, 968, 10.1016/j.intimp.2009.04.002 Franchi, 2019, Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies, Front. Immunol., 10, 2914, 10.3389/fimmu.2019.02914 Sacerdote, 1997, Effects of Tramadol on Immune Responses and Nociceptive Thresholds in Mice, Pain, 72, 325, 10.1016/S0304-3959(97)00055-9 Saeed, 2021, New Insights on Tramadol and Immunomodulation, Curr. Oncol. Rep., 23, 123, 10.1007/s11912-021-01121-y Morris, 2016, CD40 Promotes MHC Class II Expression on Adipose Tissue Macrophages and Regulates Adipose Tissue CD4 + T Cells with Obesity, J. Leukocyte Biol., 99, 1107, 10.1189/jlb.3A0115-009R Peng, 1996, Accessory Signaling by CD40 for T Cell Activation: Induction of Th1 and Th2 Cytokines and Synergy with Interleukin-12 for Interferon-Gamma Production, Eur. J. Immunol., 26, 1621, 10.1002/eji.1830260732 Greco, 2003, Paracetamol Effectively Reduces Prostaglandin E2 Synthesis in Brain Macrophages by Inhibiting Enzymatic Activity of Cyclooxygenase but Not Phospholipase and Prostaglandin E Synthase, J. Neurosci. Res., 71, 844, 10.1002/jnr.10543 Botting, 2000, Paracetamol-Inhibitable COX-2, J. Physiol. Pharmacol., 51, 609 Hanna, 2021, Tramadol/Dexketoprofen Analgesic Efficacy Compared with Tramadol/Paracetamol in Moderate to Severe Postoperative Acute Pain: Subgroup Analysis of a Randomized, Double-Blind, Parallel Group Trial—DAVID Study, Pain Ther., 10, 485, 10.1007/s40122-020-00228-7 Herr, 2017, The Effects of Serotonin in Immune Cells, Front. Cardiovasc. Med., 4, 48, 10.3389/fcvm.2017.00048 Abdalla, 2021, The role of adenosine A1 receptor in the peripheral tramadol’s effect in the temporomandibular joint of rats, Int. Immunopharmacol., 97, 10.1016/j.intimp.2021.107680 Sun, 2023, Immunosuppression by Opioids: Mechanisms of Action on Innate and Adaptive Immunity, Biochem. Pharmacol., 209, 10.1016/j.bcp.2023.115417