Immunometabolic responses according to physical fitness status and lifelong exercise during aging: New roads for exercise immunology
Tài liệu tham khảo
Aguiar, 2019, Influence of body fat on oxidative stress and telomere length of master athletes, J. Strength Cond. Res., 10.1519/JSC.0000000000002932
Almeida, 2016, Metabolic pathways in T cell activation and lineage differentiation, Semin. Immunol., 28, 514, 10.1016/j.smim.2016.10.009
Antunes, 2019, Anti-inflammatory response to acute exercise is related with intensity and physical fitness, J. Cell. Biochem., 120, 5333, 10.1002/jcb.27810
Astrand, 1973, Reduction in maximal oxygen uptake with age, J. Appl. Physiol., 35, 649, 10.1152/jappl.1973.35.5.649
Auffray, 2007, Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior, Science, 317, 666, 10.1126/science.1142883
Aw, 2018, Monocyte subsets in atherosclerosis and modification with exercise in humans, Antioxidants, 7, 196, 10.3390/antiox7120196
Azizbeigi, 2015, Effect of moderate and high resistance training intensity on indices of inflammatory and oxidative stress, Res. Sports Med., 23, 73, 10.1080/15438627.2014.975807
Bauer, 2018, Remembering pathogen dose: long-term adaptation in innate immunity, Trends Immunol., 39, 438, 10.1016/j.it.2018.04.001
Bishop, 2014, Effect of acute and regular exercise on growth hormone secretagogue receptor-1a expression in human lymphocytes, T cell subpopulation and monocytes, Brain Behav. Immun., 39, 172, 10.1016/j.bbi.2013.09.017
Biswas, 2012, Orchestration of metabolism by macrophages, Cell Metab., 15, 432, 10.1016/j.cmet.2011.11.013
Booth, 2017, Role of inactivity in chronic diseases: evolutionary insight and pathophysiological mechanisms, Physiol. Rev., 97, 1351, 10.1152/physrev.00019.2016
Bratic, 2013, The role of mitochondria in aging, J. Clin. Invest., 123, 951, 10.1172/JCI64125
Butcher, 2001, Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans, J. Leukoc. Biol., 70, 881, 10.1189/jlb.70.6.881
Cabral-Santos, 2015, Similar anti-inflammatory acute responses from moderate-intensity continuous and high-intensity intermittent exercise, J. Sports Sci. Med., 14, 849
Cabral-Santos, 2019, Interleukin-10 responses from acute exercise in healthy subjects: a systematic review, J. Cell. Physiol., 234, 9956, 10.1002/jcp.27920
Calçada, 2014, The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach, Mech. Ageing Dev., 136-137, 138, 10.1016/j.mad.2014.01.004
Chang, 2016, Emerging concepts of T cell metabolism as a target of immunotherapy, Nat. Immunol., 17, 364, 10.1038/ni.3415
Chapman, 2014, mTOR links environmental signals to t cell fate decisions, Front. Immunol., 5, 686
Chen, 2013, Molecular mechanisms of T cell co-stimulation and co-inhibition, Nat. Rev. Immunol., 13, 227, 10.1038/nri3405
Chen, 2019, Meta-inflammaging at the crossroad of geroscience, Aging Med. (Milton), 2, 157, 10.1002/agm2.12078
Conte, 2020, Mitochondria, immunosenescence and inflammaging: a role for mitokines?, Semin. Immunopathol., 10.1007/s00281-020-00813-0
Curi, 2017, A past and present overview of macrophage metabolism and functional outcomes, Clin. Sci., 131, 1329, 10.1042/CS20170220
de Araújo, 2015, Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine, Age Dordr., 37, 105, 10.1007/s11357-015-9843-4
De Rosa, 2015, Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants, Nat. Immunol., 16, 1174, 10.1038/ni.3269
de Souza Teixeira, 2020, Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker, Life Sci., 261, 10.1016/j.lfs.2020.118453
Delgoffe, 2009, mTOR: taking cues from the immune microenvironment, Immunology, 127, 459, 10.1111/j.1365-2567.2009.03125.x
Delgoffe, 2011, The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2, Nat. Immunol., 12, 295, 10.1038/ni.2005
Deretic, 2013, Autophagy in infection, inflammation and immunity, Nat. Rev. Immunol., 13, 722, 10.1038/nri3532
Desch, 2014, Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction, Nat. Commun., 5, 4674, 10.1038/ncomms5674
Diaz, 2016, Patterns of sedentary behavior in US middle-age and older adults: the REGARDS study, Med. Sci. Sports Exerc., 48, 430, 10.1249/MSS.0000000000000792
Dietz, 2015, Management of obesity: improvement of health-care training and systems for prevention and care, Lancet, 385, 2521, 10.1016/S0140-6736(14)61748-7
Ding, 2016, The economic burden of physical inactivity: a global analysis of major non-communicable diseases, Lancet, 388, 1311, 10.1016/S0140-6736(16)30383-X
Dobbs, 2014
Dorneles, 2019, Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men, Scand. J. Med. Sci. Sports, 29, 1755, 10.1111/sms.13506
Dorneles, 2019, Physical fitness modulates the expression of CD39 and CD73 on CD4(+) CD25(-) and CD4(+) CD25(+) T cells following high intensity interval exercise, J. Cell. Biochem., 120, 10726, 10.1002/jcb.28364
Dorneles, 2021, Levels of cardiorespiratory fitness in men exerts strong impact on lymphocyte function after mitogen stimulation, J. Appl. Physiol. (1985), 10.1152/japplphysiol.01051.2020
Ekelund, 2016, Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women, Lancet, 388, 1302, 10.1016/S0140-6736(16)30370-1
Elsner, 2019, Exercise-induced BDNF production by mononuclear cells of sedentary and physically active obese men, J. Sports Med. Phys. Fitness
Ezema, 2014, Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial, Niger. J. Clin. Pract., 17, 543, 10.4103/1119-3077.141414
Febbraio, 2005, Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?, Exerc. Sport Sci. Rev., 33, 114, 10.1097/00003677-200507000-00003
Fragala, 2011, Leukocyte beta2-adrenergic receptor expression in response to resistance exercise, Med. Sci. Sports Exerc., 43, 1422, 10.1249/MSS.0b013e31820b88bc
Freedland, 2004, Examining the relationship between obesity and prostate cancer, Rev. Urol., 6, 73
Friedman, 2016, The long road to leptin, J. Clin. Invest., 126, 4727, 10.1172/JCI91578
Frontera, 1991, A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women, J. Appl. Physiol. (1985), 71, 644, 10.1152/jappl.1991.71.2.644
Frontera, 2000, Aging of skeletal muscle: a 12-yr longitudinal study, J. Appl. Physiol. (1985), 88, 1321, 10.1152/jappl.2000.88.4.1321
Fukuzumi, 1996, Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1, Infect. Immun., 64, 108, 10.1128/iai.64.1.108-112.1996
Fulop, 2016, From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation, Biogerontology, 17, 147, 10.1007/s10522-015-9615-7
Gatza, 2011, Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease, Sci. Transl. Med., 3, 10.1126/scitranslmed.3001975
Gerosa-Neto, 2020, High- and moderate-intensity training modify LPS-induced ex-vivo interleukin-10 production in obese men in response to an acute exercise bout, Cytokine, 136, 10.1016/j.cyto.2020.155249
Gerriets, 2015, Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation, J. Clin. Invest., 125, 194, 10.1172/JCI76012
Gleeson, 2007, Immune function in sport and exercise, J. Appl. Physiol. (1985), 103, 693, 10.1152/japplphysiol.00008.2007
Glick, 2010, Autophagy: cellular and molecular mechanisms, J. Pathol., 221, 3, 10.1002/path.2697
Guarami, 2003, Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2, Mol Cell., 11, 1457, 10.1016/S1097-2765(03)00220-X
Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol. Cell, 30, 214, 10.1016/j.molcel.2008.03.003
Hall, 2016, TOR and paradigm change: cell growth is controlled, Mol. Biol. Cell, 27, 2804, 10.1091/mbc.e15-05-0311
Hallal, 2012, Global physical activity levels: surveillance progress, pitfalls, and prospects, Lancet, 380, 247, 10.1016/S0140-6736(12)60646-1
Hamers, 2019, Human monocyte heterogeneity as revealed by high-dimensional mass cytometry, Arterioscler. Thromb. Vasc. Biol., 39, 25, 10.1161/ATVBAHA.118.311022
Handzlik, 2013, The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells, Eur. J. Appl. Physiol., 113, 1839, 10.1007/s00421-013-2614-y
Hara, 2015, ATP regulation in bioproduction, Microb. Cell Fact., 14, 198, 10.1186/s12934-015-0390-6
Hara, 2002, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action, Cell, 110, 177, 10.1016/S0092-8674(02)00833-4
Harris, 1953, Chemotaxis of monocytes, Br. J. Exp. Pathol., 34, 276
Haschemi, 2012, The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism, Cell Metab., 15, 813, 10.1016/j.cmet.2012.04.023
Hearps, 2012, Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function, Aging Cell, 11, 867, 10.1111/j.1474-9726.2012.00851.x
Herzig, 2018, AMPK: guardian of metabolism and mitochondrial homeostasis, Nat. Rev. Mol. Cell Biol., 19, 121, 10.1038/nrm.2017.95
Hsieh, 2020, M2b macrophage subset decrement as an indicator of cognitive function in Alzheimer’s disease, Psychiatry Clin. Neurosci., 74, 383, 10.1111/pcn.13000
Infantino, 2011, The mitochondrial citrate carrier: a new player in inflammation, Biochem. J., 438, 433, 10.1042/BJ20111275
Inoue, 2020, Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults, Sci. Rep., 10, 10.1038/s41598-020-70326-1
Intlekofer, 2005, Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin, Nat. Immunol., 6, 1236, 10.1038/ni1268
Jacinto, 2004, Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive, Nat. Cell Biol., 6, 1122, 10.1038/ncb1183
Jakubzick, 2013, Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes, Immunity, 39, 599, 10.1016/j.immuni.2013.08.007
Jenny, 2012, Inflammation in aging: cause, effect, or both?, Discov. Med., 13, 451
Jung, 2019, Metabolism as a guiding force for immunity, Nat. Cell Biol., 21, 85, 10.1038/s41556-018-0217-x
Kang, 2008, De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR, J. Leukoc. Biol., 83, 1230, 10.1189/jlb.1207851
Kapellos, 2019, Human monocyte subsets and phenotypes in major chronic inflammatory diseases, Front. Immunol., 10, 2035, 10.3389/fimmu.2019.02035
Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5
Kim, 2003, GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR, Molecular Cell, 11, 895, 10.1016/S1097-2765(03)00114-X
Klysz, 2015, Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation, Vol. 8, ra97
Koch, 2011, Mechanisms of T cell development and transformation, Annu. Rev. Cell Dev. Biol., 27, 539, 10.1146/annurev-cellbio-092910-154008
Krüger, 2007, T cell homing and exercise, Exerc. Immunol. Rev., 13, 37
Krüger, 2008, Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms, Brain Behav. Immun., 22, 324, 10.1016/j.bbi.2007.08.008
Krüger, 2009, Exercise affects tissue lymphocyte apoptosis via redox-sensitive and Fas-dependent signaling pathways, Am. J. Physiol. Regul. Integr. Comp. Physiol., 296, R1518, 10.1152/ajpregu.90994.2008
Krüger, 2016, The immunomodulatory effects of physical activity, Curr. Pharm. Des., 22, 3730, 10.2174/1381612822666160322145107
Kusy, 2015, Sprinters versus long-distance runners: how to grow old healthy, Exerc. Sport Sci. Rev., 43, 57, 10.1249/JES.0000000000000033
Landmann, 1992, Beta-adrenergic receptors in human leukocyte subpopulations, Eur. J. Clin. Invest., 22, 30
Lanna, 2014, The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells, Nat. Immunol., 15, 965, 10.1038/ni.2981
Larson, 2016, Ly6C(+) monocyte efferocytosis and cross-presentation of cell-associated antigens, Cell Death Differ., 23, 997, 10.1038/cdd.2016.24
Lavin, 2020, Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation, J. Appl. Physiol. (1985), 128, 87, 10.1152/japplphysiol.00495.2019
Lee, 2012, Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy, Lancet, 380, 219, 10.1016/S0140-6736(12)61031-9
León, 2007, Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania, Immunity, 26, 519, 10.1016/j.immuni.2007.01.017
Lewis, 2009, Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association, Circulation, 119, 3263, 10.1161/CIRCULATIONAHA.109.192574
Li, 2018, Macrophage polarization and meta-inflammation, Transl. Res., 191, 29, 10.1016/j.trsl.2017.10.004
Linehan, 2014, Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis, Aging Cell, 13, 699, 10.1111/acel.12223
Linke, 2017, mTORC1 and mTORC2 as regulators of cell metabolism in immunity, FEBS Lett., 591, 3089, 10.1002/1873-3468.12711
Liu, 2017, α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming, Nat. Immunol., 18, 985, 10.1038/ni.3796
Longo, 2019, Adipose tissue dysfunction as determinant of obesity-associated metabolic complications, Int. J. Mol. Sci., 20, 10.3390/ijms20092358
Lumeng, 2007, Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity, Diabetes, 56, 16, 10.2337/db06-1076
Luo, 2011, Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1, Cell, 145, 732, 10.1016/j.cell.2011.03.054
Lurier, 2017, Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing, Immunobiology, 222, 847, 10.1016/j.imbio.2017.02.006
Macdougall, 2018, Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets, Cell Metab., 27, 588, 10.1016/j.cmet.2018.02.007
Mah, 2017, Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control, JCI Insight, 2, 10.1172/jci.insight.95128
Makowski, 2020, Immunometabolism: from basic mechanisms to translation, Immunol. Rev., 295, 5, 10.1111/imr.12858
Mills, 1999, Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise, Eur. J. Appl. Physiol. Occup. Physiol., 79, 531, 10.1007/s004210050548
Minuzzi, 2017, Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes, Eur. J. Appl. Physiol., 117, 1131, 10.1007/s00421-017-3600-6
Minuzzi, 2018, Effects of lifelong training on senescence and mobilization of T lymphocytes in response to acute exercise, Exerc. Immunol. Rev., 24, 72
Minuzzi, 2019, Lifelong exercise practice and immunosenescence: master athletes cytokine response to acute exercise, Cytokine, 115, 1, 10.1016/j.cyto.2018.12.006
Minuzzi, 2021, Immunometabolism and covid-19: could lifelong exercise training have a protective effect?, Immunometabolism, 3, 10.20900/immunometab20210001
Moon, 2015, mTORC1-induced HK1-Dependent glycolysis regulates NLRP3 inflammasome activation, Cell Rep., 12, 102, 10.1016/j.celrep.2015.05.046
Müller-Durovic, 2016, Killer cell lectin-like receptor G1 inhibits NK cell function through activation of adenosine 5’-monophosphate-activated protein kinase, J. Immunol., 197, 2891, 10.4049/jimmunol.1600590
Murray, 1992, Sympathetic and immune interactions during dynamic exercise. Mediation via a beta 2-adrenergic-dependent mechanism, Circulation, 86, 203, 10.1161/01.CIR.86.1.203
NCD-RisC, 2017, Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults, Lancet, 390, 2627, 10.1016/S0140-6736(17)32129-3
Newsholme, 1985, The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells, Biosci. Rep., 5, 393, 10.1007/BF01116556
Newsholme, 1986, Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages, Biochem. J., 239, 121, 10.1042/bj2390121
Newsholme, 1987, Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages, Biochem. J., 242, 631, 10.1042/bj2420631
Nicholson, 2016, The immune system, Essays Biochem., 60, 275, 10.1042/EBC20160017
O’Neill, 2013, Metabolism of inflammation limited by AMPK and pseudo-starvation, Nature, 493, 346, 10.1038/nature11862
O’Neill, 2016, A guide to immunometabolism for immunologists, Nat. Rev. Immunol., 16, 553, 10.1038/nri.2016.70
O’Sullivan, 2015, Targeting T cell metabolism for therapy, Trends Immunol., 36, 71, 10.1016/j.it.2014.12.004
Nojima, 2003, The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif, Journal of Biology Chemistry, 278, 15461, 10.1074/jbc.C200665200
Oestreich, 2012, Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors, Nat. Rev. Immunol., 12, 799, 10.1038/nri3321
Oishi, 2016, Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue, Clin. Exp. Pharmacol. Physiol., 43, 294, 10.1111/1440-1681.12539
Ortega, 2016, The “bioregulatory effect of exercise” on the innate/inflammatory responses, J. Physiol. Biochem., 72, 361, 10.1007/s13105-016-0478-4
Pascual, 2005, A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma, Nature, 437, 759, 10.1038/nature03988
Pawelec, 2017, Does the human immune system ever really become "senescent"?, F1000Res, 4, 1323, 10.12688/f1000research.11297.1
Pawelec, 2018, Age and immunity: what is “immunosenescence”?, Exp. Gerontol., 105, 4, 10.1016/j.exger.2017.10.024
Pawelec, 2001, Altered T cell signalling in ageing, Mech. Ageing Dev., 122, 1613, 10.1016/S0047-6374(01)00290-1
Pearce, 2010, Metabolism in T cell activation and differentiation, Curr. Opin. Immunol., 22, 314, 10.1016/j.coi.2010.01.018
Pearce, 2013, Metabolic pathways in immune cell activation and quiescence, Immunity, 38, 633, 10.1016/j.immuni.2013.04.005
Pearce, 2003, Control of effector CD8+ T cell function by the transcription factor Eomesodermin, Science, 302, 1041, 10.1126/science.1090148
Pedersen, 2009, The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk, J. Physiol., 587, 5559, 10.1113/jphysiol.2009.179515
Pedersen, 2017, Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease, Eur. J. Clin. Invest., 47, 600, 10.1111/eci.12781
Pedersen, 2016, Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution, Cell Metab., 23, 554, 10.1016/j.cmet.2016.01.011
Perkins, 2020, Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle, J. Appl. Physiol. (1985), 10.1152/japplphysiol.00615.2020
Petersen, 2005, The anti-inflammatory effect of exercise, J. Appl. Physiol. (1985), 98, 1154, 10.1152/japplphysiol.00164.2004
Powell, 2012, Regulation of immune responses by mTOR, Annu. Rev. Immunol., 30, 39, 10.1146/annurev-immunol-020711-075024
Powers, 2010, Reactive oxygen species are signalling molecules for skeletal muscle adaptation, Exp. Physiol., 95, 1, 10.1113/expphysiol.2009.050526
Poznanski, 2018, Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function, Inflamm. Res., 67, 813, 10.1007/s00011-018-1174-3
Radak, 2019, Exercise effects on physiological function during aging, Free Radic. Biol. Med., 132, 33, 10.1016/j.freeradbiomed.2018.10.444
Rigsby, 1992, Effects of exercise training on men seropositive for the human immunodeficiency virus-1, Med. Sci. Sports Exerc., 24, 6, 10.1249/00005768-199201000-00003
Robinson, 2015, Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes, J. Appl. Physiol. (1985), 119, 508, 10.1152/japplphysiol.00334.2015
Rodriguez, 2021, Immunosenescence study of t cells: a systematic review, Front. Immunol., 15, 604591, 10.3389/fimmu.2020.604591
Ross, 2018, Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men, Am. J. Physiol. Heart Circ. Physiol., 314, H392, 10.1152/ajpheart.00592.2017
Ruffino, 2016, Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARgamma, Eur. J. Appl. Physiol., 116, 1671, 10.1007/s00421-016-3414-y
Saare, 2020, Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism, Aging Cell, 19, 10.1111/acel.13127
Santoro, 2020, Inflammaging, hormesis and the rationale for anti-aging strategies, Ageing Res. Rev., 10.1016/j.arr.2020.101142
Santos, 2020, Dynamics of anthropometric indices in a large paired cohort with 10 years of follow-up: paving the way to sarcopenic obesity, Front. Endocrinol. (Lausanne), 11, 209, 10.3389/fendo.2020.00209
Saunders, 2001, Rapamycin in transplantation: a review of the evidence, Kidney Int ., 59, 3, 10.1046/j.1523-1755.2001.00460.x
Schmelzle, 2000, TOR, a central controller of cell growth, Cell, 103, 253, 10.1016/S0092-8674(00)00117-3
Selak, 2005, Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase, Cancer Cell, 7, 77, 10.1016/j.ccr.2004.11.022
Serbina, 2003, TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection, Immunity, 19, 59, 10.1016/S1074-7613(03)00171-7
Shao, 2019, Alpha7 nicotinic acetylcholine receptor alleviates inflammatory bowel disease through induction of AMPK-mTOR-p70S6K-Mediated autophagy, Inflammation, 42, 1666, 10.1007/s10753-019-01027-9
Shaw, 2010, Aging of the innate immune system, Curr. Opin. Immunol., 22, 507, 10.1016/j.coi.2010.05.003
Shi, 2011, Monocyte recruitment during infection and inflammation, Nat. Rev. Immunol., 11, 762, 10.1038/nri3070
Silveira, 2016, Macrophage polarization: implications on metabolic diseases and the role of exercise, Crit. Rev. Eukaryot. Gene Expr., 26, 115, 10.1615/CritRevEukaryotGeneExpr.2016015920
Simoes, 2017, Longer telomere length in elite master sprinters: relationship to performance and body composition, Int. J. Sports Med., 38, 1111, 10.1055/s-0043-120345
Simpson, 2011, Aging, persistent viral infections, and immunosenescence: can exercise “make space”?, Exerc. Sport Sci. Rev., 39, 23, 10.1097/JES.0b013e318201f39d
Simpson, 2014, Special issue on exercise immunology: current perspectives on aging, health and extreme performance, Brain Behav. Immun., 39, 1, 10.1016/j.bbi.2014.03.006
Simpson, 2015, Exercise and the regulation of immune functions, Prog. Mol. Biol. Transl. Sci., 135, 355, 10.1016/bs.pmbts.2015.08.001
Simpson, 2016, Human cytomegalovirus infection and the immune response to exercise, Exerc Immunol Ver, 22, 8
Simpson, 2020, Can exercise affect immune function to increase susceptibility to infection?, Exerc. Immunol. Rev., 26, 8
Solana, 2012, Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans, Semin. Immunol., 24, 331, 10.1016/j.smim.2012.04.008
Sotak, 2020, Adipocytokines and thyreopathies, Vnitr. Lek., 66, 47, 10.36290/vnl.2020.035
Spielmann, 2011, Aerobic fitness is associated with lower proportions of senescent blood T-cells in man, Brain Behav. Immun., 25, 1521, 10.1016/j.bbi.2011.07.226
Suzuki, 2019, Chronic inflammation as an immunological abnormality and effectiveness of exercise, Biomolecules, 9, 223, 10.3390/biom9060223
Szabo, 2000, A novel transcription factor, T-bet, directs Th1 lineage commitment, Cell, 100, 655, 10.1016/S0092-8674(00)80702-3
Tanaka, 2008, Endurance exercise performance in masters athletes: age-associated changes and underlying physiological mechanisms, J. Physiol., 586, 55, 10.1113/jphysiol.2007.141879
Tannahill, 2013, Succinate is an inflammatory signal that induces IL-1β through HIF-1α, Nature, 496, 238, 10.1038/nature11986
Tarique, 2015, Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages, Am. J. Respir. Cell Mol. Biol., 53, 676, 10.1165/rcmb.2015-0012OC
Teixeira, 2021, Lifelong exercise improvement in effector-1 memory CD4+ response and anti-inflammatory profile are related to clock gene expression in master athletes, Exerc. Immunol. Rev.
Thompson, 2011, Rethinking the regulation of cellular metabolism, Cold Spring Harb. Symp. Quant. Biol., 76, 23, 10.1101/sqb.2012.76.010496
Tsai, 2016, Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males, Sci. Rep., 6, 10.1038/srep35170
Turner, 2016, Is immunosenescence influenced by our lifetime "dose" of exercise?, Biogerontology, 17, 581, 10.1007/s10522-016-9642-z
Vander Haar, 2007, Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40, Nat. Cell Biol., 9, 316, 10.1038/ncb1547
Varela, 2018, Mapping the historical development of physical activity and health research: a structured literature review and citation network analysis, Prev. Med., 111, 466, 10.1016/j.ypmed.2017.10.020
Vats, 2006, Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation, Cell Metab., 4, 13, 10.1016/j.cmet.2006.05.011
Voehringer, 2002, Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1), Blood, 100, 3698, 10.1182/blood-2002-02-0657
Von Ah Morano, 2020, The role of glucose homeostasis on immune function in response to exercise: the impact of low or higher energetic conditions, J. Cell. Physiol., 235, 3169, 10.1002/jcp.29228
Waickman, 2012, mTOR, metabolism, and the regulation of T-cell differentiation and function, Immunol. Rev., 249, 43, 10.1111/j.1600-065X.2012.01152.x
Walsh, 2018, Recommendations to maintain immune health in athletes, Eur. J. Sport Sci., 18, 820, 10.1080/17461391.2018.1449895
Wang, 2018, Glycolytic stimulation is not a requirement for M2 macrophage differentiation, Cell Metab., 28, 463, 10.1016/j.cmet.2018.08.012
Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309
Warren, 2012, Leptin and cognition, Dement. Geriatr. Cogn. Disord., 33, 410, 10.1159/000339956
WHO, 2010
WHO, 2018
Wolf, 2014, Interleukin-6 and its receptors: a highly regulated and dynamic system, Cytokine, 70, 11, 10.1016/j.cyto.2014.05.024
Wolf, 2019, The ontogeny of monocyte subsets, Front. Immunol., 10, 1642, 10.3389/fimmu.2019.01642
Wu, 2001, Sex differences of body fat distribution and cardiovascular dysmetabolic factors in old age, Age Ageing, 30, 331, 10.1093/ageing/30.4.331
Yang, 2012, mTOR and metabolic pathways in T cell quiescence and functional activation, Semin Immunol., 24, 421, 10.1016/j.smim.2012.12.004
Yarbro, 2020, Macrophage immunometabolism and inflammaging: roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD, Immunometabolism, 2, 10.20900/immunometab20200026
Yeung, 2004, Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase, EMBO J., 23, 2369, 10.1038/sj.emboj.7600244
Zeng, 2013, mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function, Nature, 499, 485, 10.1038/nature12297
Zhang, 2015, Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway, Eur. J. Pharmacol., 754, 41, 10.1016/j.ejphar.2015.02.004
Zhang, 2016, Mammalian target of rapamycin complex 2 controls CD8 t cell memory differentiation in a Foxo1-dependent manner, Cell Rep., 14, 1206, 10.1016/j.celrep.2015.12.095
Zhang, 2017, Astrocytic process plasticity and IKKbeta/NF-kappaB in central control of blood glucose, blood pressure, and body weight, Cell Metab., 25, 1091, 10.1016/j.cmet.2017.04.002
Zhang, 2020, Injection suppresses production of Interleukin-6 by activating autophagy through the AMPK-mTOR pathway in lipopolysaccharide-stimulated macrophages, Oxid. Med. Cell. Longev., 2020
Zheng, 2007, A role for mammalian target of rapamycin in regulating T cell activation versus anergy, J. Immunol., 178, 2163, 10.4049/jimmunol.178.4.2163
Ziegler-Heitbrock, 2010, Nomenclature of monocytes and dendritic cells in blood, Blood, 116, e74, 10.1182/blood-2010-02-258558