Immunohistochemical demonstration of FC receptors in rat tissues using immune complexes as ligand
Tóm tắt
To demonstrate the presence and localization of Fc receptors, rat liver cryostat sections were incubated with heterologous and autologous immune complexes (ICx) and immunoglobulin (Ig) aggregates. Binding was demonstrated using the immunoperoxidase technique. Autologous and heterologous ICx as well as aggregates from human and rat Ig appeared to bind to the sinusoidal wall. ICx bind in preference to aggregates. Monomeric Ig and aggregated Ig from swine and rabbit did not bind. The results demonstrated that ICx and rat and human Ig aggregates were bound via an Fc receptor. This Fc receptor was still intact in livers from carbontetra chloride and galactosamine treated rats. The receptor could also be demonstrated on spleen macrophages and on kidney interstitial cells. This method turned out to be an useful functional histochemical method to localize Fc receptors and to demonstrate their affinity and species specificity in tissues.
Tài liệu tham khảo
Anderson CL, Grey HM (1974) Receptor for aggregated IgG on mouse lymphocytes: Their presence on thymocytes, thymus derived and bone marrow derived lymphocytes. J Exp Med 139:1175–1183
Arend WP, Mannik M (1972) In vitro adherence of soluble immune complexes to macrophages. J Exp Med 136:514–529
Arend WP, Mannik M (1973) The macrophage receptor for IgG: number and affinity of binding sites. J Immunol 110:1455–1464
Askenase PW, Hayden BJ (1974) Cytophilic antibodies in mice contact sensitized with oxazolone. Immunochemical characterization and preferential binding to a trypsin-sensitive macrophage receptor. Immunology 27:563–571
Basten A, Miller JFAP, Sprent J, Pye J (1972) A receptor for antibody on B lymphocytes I. J Exp Med 135:610–626
Boltz-Nitulescu G, Bazin H, Spiegelberg H (1981) Specificity of Fc receptors for IgG2a, IgG1/IgG2b, and IgG3 on rat macrophages. J Exp Med 154:374–384
Decker K, Keppler D (1972) Galactosamine induced liver injury. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 4. Grune and Stratton, New York, pp 183–199
Dickler HB, Kunkel HG (1972) Interaction of aggregated gamma globulin with B lymphocytes. J Exp Med 136:191–195
Dower SK, DeLisi C, Titus JA, Segal DM (1981) Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding. Biochemistry 20:6326–6334
Elner VM, Hass AJ, Davis HR, Glagov S (1983) An avidin-biotinperoxidase method for Fc receptors on macrophages isolated from and in sections of rat lung. J Histochem Cytochem 31:1139–1141
Froese A, Paraskevas F (1983) (eds) Structure and function of Fc receptors. Marcel Dekker, New York
Frommel D, Rachman F (1979) Receptor for the Fc portion of IgG on the plasma membrane of the hepatocyte. Ann Immunol 130C:553–556
Gauldie J, Richards C, Lamontagne L (1983) Fc receptors for IgA and other immunoglobulins on resident and activated alveolar macrophages. Mol Immunol 20:1029–1037
Gelfland MC, Frank MM, Green I (1979) Binding sites for immune complexes containing IgG in the renal interstitium. Clin Immunol Immunopathol 13:19–28
Griffin FM (1980) Effects of soluble immune complexes on Fc receptor and C3b receptor-mediated phagocytosis by macrophages. J Exp Med 152:905–912
Groothuis GMM, Weitering JG, Hardonk MJ, Meijer DKF (1983a) Heterogeneity of rat hepatocytes in transport and hepatic binding of asialo-alkaline phosphatase studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbontetrachloride. Biochem Pharmacology 32:2721–2727
Groothuis GMM, Meijer DKF, Hardonk MJ (1983b) Morphological studies on selective acinar liver damage by N-hydroxy-2-acetylaminofluorene and carbontetrachloride. Arch Pharmacol 322:298–309
Hardonk MJ, Dijkhuis FWJ, Feringa A, Koudstaal J (1982) The development of granulomas in rat liver after i.v. injection of pig intestinal particulate alkaline phosphatase. In: Knook DL, Wisse E (eds) Sinusoidal liver cells. Elsevier Biomedical Press, Amsterdam, pp 185–192
Hardonk MJ, Haarsma TJ, Dijkhuis FWJ, Poel M, Koudstaal J (1977) Influence of fixation and buffer treatment on the release of enzymes from the plasma membrane. Histochemistry 54:57–66
Heuser CH, Anderson CL, Grey HM (1977) Receptors for IgG: Subclass specificity of receptors on different mouse cell types and the definition of two distinct receptors on a macrophage cell line. J Exp Med 145:1316–1322
Itoh G, Miura S, Suzuki I (1977) Immunohistochemical detection of Fc receptors. I: Light microscopic demonstration of Fc receptor by using soluble immune complexes of peroxidase antiperoxidase immunglobulin G. J Histochem Cytochem 25:252–258
Jimenez RAH, Mannik M (1982) Evaluation of aggregated IgG in mice as an Fc receptor probe of the hepatic mononuclear phagocyte system. Clin Exp Immunol 49:200–209
Jimenez RM, Appay MD, Bellon B, Kuhn J, Bariety J, Druet P (1984) IgG Fc membrane receptor on normal human glomerular visceral epithelial cells. Virchows Arch (Pathol Anat) 404:139–158
Kijlstra A (1974) Fate of circulating immune complexes. Thesis, Krips Repro B. V. Meppel, The Netherlands
Leslie RGQ (1982) The characterization of cell receptors for IgG. Immunol Today 3, 10:265–267
Leslie RGQ, Coupland K (1985) The ingestion and degradation of soluble immune complexes by guinea-pig macrophages and neutrophils. Immunology 54:811–819
Leslie RGQ, Niemetz AH (1979) Species specificity in the binding of IgG to macrophages. Immunology 37:835–840
Mellman IS (1982) Membrane recycling. Evered D, Collins GM (eds) Ciba Foundation symposium 92. Pitman, London, pp 35–59
Mizoguchi Y, Horiuchi Y (1982) Localisation of IgG receptors in human renal glomeruli. Clin Immunol 24:320–329
Mizoguchi Y, Tanimoto K, Yue CL, Horiuchi Y (1979) Immune receptors (IgG-Fc and complement receptors) in normal human organs. Lab Invest 40:703–708
Mota G, Moraru I, Sjoquist J, Ghetie V (1981) Protein A as a molecular probe for the detection of antigen induced conformational change in Fc region of rabbit antibody. Mol Immunol 18:373–378
Petty HR, Hafeman DG, McConnel HM (1980) Specific antibody-dependent phagocytosis of lipid vesicles by RAW264 macrophages results in the loss of cell surface Fc but not C3b receptor activity. J Immunol 125:2391–2398
Rasmussen JM, Brandslund I, Leslie RGQ, Svehag SE (1983) Quantitative studies of Fc receptors on human monocytes: Characterisation by binding of homologous and heterologous monomeric IgG and soluble ICx of different composition. Immunology 49:537–544
Salmon JE, Kinberly RP, Gibofsky A, Fotino M (1984) Defective mononuclear phagocyte function in systemic lupus erythematosus: Dissociation of Fc receptor-ligand binding and internalization. J Immunol 133:2525–2531
Shingu M, Hashimoto Y, Johnson AR, Hurd ER (1981) The search for Fc receptors on human tissues and human endothelial cells in culture. Proc Soc Exp Biol Med 167:147
Straus W (1983) Cytochemical observations on mannose-specific binding sites for horse radish peroxidase in liver sinusoidal cells. Histochemistry 77:25–35
Thunold S, Schauwenstein K, Wolf H, Thunold KS, Wick G (1981) Localisation of IgG Fc and complement receptors in chicken lymphoid tissue. Scand J Immunol 14:145–153
Thunold S, Boyd R, Schauwenstein K, Wick G (1982) Tissue localisation of lymphocyte surface antigens and receptors for immunoglobulin G Fc and complement in the chicken. J Histochem Cytochem 30:201–206
Unkeless JC (1977) The presence of two Fc receptors on mouse macrophages: Evidence from a variant cell line and differential trypsin sensitivity. J Exp Med 145:931–947
Unkeless JC, Kaplan G, Plutner H, Cohn ZA (1979) Fc receptor variants of a macrophage cell line. Proc Natl Acad Sci USA 76:1400–1411
Van der Laan-Klamer SM, Atmosoerodjo-Briggs JE, Harms G, Hardonk MJ, Hoedemaeker PhJ (1985) A histochemical study about the involvement of rat liver cells in the uptake of heterologous immune complexes from the circulation. Histochemistry 82:477–483
Van der Laan-Klamer SM, Harms G, Atmosoerodjo-Briggs JE, Hardonk MJ, Hoedemaeker PhJ (1986a) Studies on the mechanism of ICx binding to rat liver cells. Scand J Immunol
Van der Laan-Klamer SM, Harms G, Atmosoerodjo-Briggs JE, Hoedemacker PhJ, Hardonk MJ (1986b) Hepatic uptake of autologous immune complexes. Scand J Immunol (in press)