Immunohistochemical analysis of soft tissues in implants with healthy and peri‐implantitis condition, and aggressive periodontitis

Clinical Oral Implants Research - Tập 15 Số 5 - Trang 553-559 - 2004
Pedro Bullón1, Massimiliano Fioroni, Gaia Goteri, Corrado Rubini, Maurizio Battino
1Dental School, University of Sevilla, Spain. [email protected]

Tóm tắt

Abstract: Today, implant‐supported prostheses are widely accepted as a reliable treatment modality, but failures in longitudinal studies have been shown. In some cases, peri‐implantitis with a progressive periodontal bone loss takes place, and mechanical or load factors and biological or plaque‐induced lesions have been claimed as main etiologic factors. We compared five cases of peri‐implantitis, with five cases of healthy peri‐implant tissues and five cases of aggressive periodontitis in order to give new findings on the osseointegration loss process. Biopsy specimens from the peri‐implant tissues including oral (O), sulcular, and junctional epithelium and the underlying and supracrestal connective tissue, were taken in all cases for histological and immunohistochemical analysis. T lymphocytes were the most prominent cell in the peri‐implantitis (PG) and aggressive periodontitis (AG) groups, but not in the peri‐implant healthy group (HG). CD1a‐positive cells (Langerhans and immature dendritic cells) were observed more frequently in the O than in the sulcular–junctional (S–J) epithelium: they were located in the basal and parabasal layers, without any differences between the three groups. Vascular proliferation analysed by immunoreactivity for CD34, Factor VIII, and vascular endothelial growth factor was more prominent in the PG comparing with HG and AG in the S–J area. Apoptosis, analysed by bcl2 and p53 immunoreactivity, was similar in the three groups. In conclusion, we suggest that the osseointegration loss process is due to an inflammatory process similar to that observed in aggressive periodontitis according to the number of T lymphocytes, but not to the vascular proliferation.

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Tài liệu tham khảo

Albrektsson T., 1994, Proceedings of the 1st European Workshop on Periodontology, 365

10.1034/j.1600-0501.1996.070101.x

10.1038/32588

10.1111/j.1600-051X.1998.tb02418.x

10.1111/j.1600-0765.1998.tb02349.x

10.1034/j.1600-0501.1997.080302.x

Cornelini R., 2001, Vascular endothelial growth factor and microvessel density around healthy and failing dental implants, International Journal of Oral & Maxillofacial Implants, 16, 389

Crawfordt J.M., 1989, The distribution of Langerhans cells and CD1a antigen in healthy and diseased human gingival, Regional Immunology, 2, 91

De Smet E., 2001, The influence of plaque and/or excessive loading on marginal soft and hard tissue reactions around Branemark implants, International Journal of Periodontics and Restorative Dentistry, 21, 381

10.1046/j.0909-8836..t01-2-.x

10.1034/j.1600-0501.1997.080502.x

10.1902/jop.2001.72.4.517

10.1034/j.1399-302X.2002.170609.x

Hoshaw S.J., 1994, Mechanical loading of Branemark implants affects interfacial bone remodeling and remodeling, International Journal of Oral & Maxillofacial Implants, 9, 345

10.1111/j.1600-0501.1997.tb00001.x

10.1034/j.1600-051X.2002.291203.x

10.1902/jop.1999.70.8.848

10.4049/jimmunol.167.8.4693

10.1034/j.1600-0501.2000.011S1146.x

10.1034/j.1600-051X.1999.260309.x

10.1034/j.1600-0501.1996.070109.x

10.1111/j.1600-051X.1997.tb00477.x

10.1152/physrev.00023.2001

10.1902/jop.2002.73.5.555

10.1034/j.1600-0501.2001.120504.x

Mombelli A., 1999, Proceedings of the 3rd European Workshop on Periodontology, 281

10.1111/j.1399-302X.1987.tb00298.x

Okada H., 1983, Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis, Infection and Immunity, 41, 365, 10.1128/iai.41.1.365-374.1983

10.1902/jop.1972.43.1.38

10.1016/S0003-9969(00)00018-2

10.1111/j.1600-051X.1979.tb01930.x

10.1007/s007840050107

10.1111/j.1600-0765.1984.tb01320.x

10.1111/j.1600-051X.1995.tb00255.x

Weibrich G., 2001, Five‐year prospective follow‐up report of the Astra tech standard dental implant in clinical treatment, International Journal of Oral & Maxillofacial Implants, 16, 557

10.1034/j.1600-051x.2001.028006517.x

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Clinical Oral Implants Research

Tập 15 Số 5

553-559

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