Immunoglobulin A and the microbiome

Turnbaugh, 2007, The human microbiome project, Nature, 449, 804, 10.1038/nature06244 Lee, 2010, Has the microbiota played a critical role in the evolution of the adaptive immune system?, Science, 330, 1768, 10.1126/science.1195568 Macpherson, 2008, The immune geography of IgA induction and function, Mucosal Immunol, 1, 11, 10.1038/mi.2007.6 Wijburg, 2006, Innate secretory antibodies protect against natural Salmonella typhimurium infection, J Exp Med, 203, 21, 10.1084/jem.20052093 van der Waaij, 1994, Direct flow cytometry of anaerobic bacteria in human feces, Cytometry, 16, 270, 10.1002/cyto.990160312 Chiba, 1987, IgA1 & IgA2 distribution in the intestine, Gastroenterol Jpn, 22, 18, 10.1007/BF02806330 Pakkanen, 2010, Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids, Clin Vaccine Immunol, 17, 393, 10.1128/CVI.00475-09 Woof, 2011, Structure and function relationships in IgA, Mucosal Immunol, 4, 590, 10.1038/mi.2011.39 Brandtzaeg, 2003, Role of secretory antibodies in the defence against infections, Int J Med Microbiol, 293, 3, 10.1078/1438-4221-00241 Plaut, 1974, Differential susceptibility of human IgA immunoglobulins to streptococcal IgA protease, J Clin Invest, 54, 1295, 10.1172/JCI107875 Lewis, 2012, Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis, J Biol Chem, 287, 2079, 10.1074/jbc.M111.278135 Lycke, 1999, Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection, J Immunol, 163, 913, 10.4049/jimmunol.163.2.913 Fagarasan, 2002, Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora, Science, 298, 1424, 10.1126/science.1077336 Sait, 2003, Secretory antibodies do not affect the composition of the bacterial microbiota in the terminal ileum of 10-week-old mice, Appl Environ Microbiol, 69, 2100, 10.1128/AEM.69.4.2100-2109.2003 Suzuki, 2004, Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut, Proc Natl Acad Sci U S A, 101, 1981, 10.1073/pnas.0307317101 Reikvam, 2012, Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice, Eur J Immunol, 42, 2959, 10.1002/eji.201242543 Kawamoto, 2014, Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis, Immunity, 41, 152, 10.1016/j.immuni.2014.05.016 Zhang, 2015, Host adaptive immunity alters gut microbiota, ISME J, 9, 770, 10.1038/ismej.2014.165 Jorgensen, 2016, Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation, Mucosal Immunol, 9, 1455, 10.1038/mi.2016.18 Fadlallah, 2018, Microbial ecology perturbation in human IgA deficiency, Sci Transl Med, 10, 10.1126/scitranslmed.aan1217 Catanzaro, 2019, IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM, Sci Rep, 9, 10.1038/s41598-019-49923-2 Proietti, 2014, ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism, Immunity, 41, 789, 10.1016/j.immuni.2014.10.010 Wei, 2011, Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense, Nat Immunol, 12, 264, 10.1038/ni.1991 Kawamoto, 2012, The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut, Science, 336, 485, 10.1126/science.1217718 Petersen, 2019, T cell-mediated regulation of the microbiota protects against obesity, Science, 365, 10.1126/science.aat9351 Perruzza, 2017, T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular ATP, Cell Rep, 18, 2566, 10.1016/j.celrep.2017.02.061 Rogier, 2014, Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression, Proc Natl Acad Sci U S A, 111, 3074, 10.1073/pnas.1315792111 Ramanan, 2020, An immunologic mode of multigenerational transmission governs a gut Treg setpoint, Cell, 10.1016/j.cell.2020.04.030 Chen, 2020, Autoreactivity in naive human fetal B cells is associated with commensal bacteria recognition, Science, 369, 320, 10.1126/science.aay9733 Mirpuri, 2014, Proteobacteria-specific IgA regulates maturation of the intestinal microbiota, Gut Microbes, 5, 28, 10.4161/gmic.26489 Gopalakrishna, 2019, Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants, Nat Med, 25, 1110, 10.1038/s41591-019-0480-9 Mathias, 2011, Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates, J Biol Chem, 286, 17239, 10.1074/jbc.M110.209015 Nakajima, 2018, IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria, J Exp Med, 215, 2019, 10.1084/jem.20180427 Sterlin, 2020, Human IgA binds a diverse array of commensal bacteria, J Exp Med, 217 Bunker, 2019, B cell superantigens in the human intestinal microbiota, Sci Transl Med, 11, 10.1126/scitranslmed.aau9356 Palm, 2014, Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease, Cell, 158, 1000, 10.1016/j.cell.2014.08.006 Rengarajan, 2019, Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease, Gut Microbes, 1 Fransen, 2015, BALB/c and C57BL/6 mice differ in polyreactive IgA abundance, which impacts the generation of antigen-specific IgA and microbiota diversity, Immunity, 43, 527, 10.1016/j.immuni.2015.08.011 Bunker, 2015, Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A, Immunity, 43, 541, 10.1016/j.immuni.2015.08.007 Kau, 2015, Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy, Sci Transl Med, 7, 10.1126/scitranslmed.aaa4877 Huus, 2020, Commensal bacteria modulate immunoglobulin A binding in response to host nutrition, Cell Host Microbe, 10.1016/j.chom.2020.03.012 Viladomiu, 2017, IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation, Sci Transl Med, 9, 10.1126/scitranslmed.aaf9655 Yang, 2020, Fecal IgA levels are determined by strain-level differences in Bacteroides ovatus and are modifiable by gut microbiota manipulation, Cell Host Microbe, 27, 467, 10.1016/j.chom.2020.01.016 Stepankova, 2007, Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells, Inflamm Bowel Dis, 13, 1202, 10.1002/ibd.20221 Cullender, 2013, Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut, Cell Host Microbe, 14, 571, 10.1016/j.chom.2013.10.009 Okai, 2016, High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice, Nat Microbiol, 1, 16103, 10.1038/nmicrobiol.2016.103 Joglekar, 2019, Intestinal IgA regulates expression of a Fructan polysaccharide utilization locus in colonizing gut commensal Bacteroides thetaiotaomicron, mBio, 10, 10.1128/mBio.02324-19 Hendrickx, 2015, Antibiotic-driven dysbiosis mediates intraluminal agglutination and alternative segregation of Enterococcus faecium from the intestinal epithelium, mBio, 6, e01346, 10.1128/mBio.01346-15 Moor, 2017, High-avidity IgA protects the intestine by enchaining growing bacteria, Nature, 544, 498, 10.1038/nature22058 Bansept, 2019, Enchained growth and cluster dislocation: a possible mechanism for microbiota homeostasis, PLoS Comput Biol, 15, 10.1371/journal.pcbi.1006986 McLoughlin, 2016, Host selection of microbiota via differential adhesion, Cell Host Microbe, 19, 550, 10.1016/j.chom.2016.02.021 Donaldson, 2018, Gut microbiota utilize immunoglobulin A for mucosal colonization, Science, 360, 795, 10.1126/science.aaq0926 Hughes, 1999, Carbohydrate moieties in human secretory component, Biochim Biophys Acta, 1434, 86, 10.1016/S0167-4838(99)00168-5 Briliute, 2019, Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci, Nat Microbiol, 4, 1571, 10.1038/s41564-019-0466-x Round, 2018, Causal effects of the microbiota on immune-mediated diseases, Sci Immunol, 3, 10.1126/sciimmunol.aao1603 Pabst, 2012, New concepts in the generation and functions of IgA, Nat Rev Immunol, 12, 821, 10.1038/nri3322 Fagarasan, 2001, In situ class switching and differentiation to IgA-producing cells in the gut lamina propria, Nature, 413, 639, 10.1038/35098100 He, 2007, Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL, Immunity, 26, 812, 10.1016/j.immuni.2007.04.014 Tsuji, 2008, Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut, Immunity, 29, 261, 10.1016/j.immuni.2008.05.014 Grootjans, 2019, Epithelial endoplasmic reticulum stress orchestrates a protective IgA response, Science, 363, 993, 10.1126/science.aat7186 Pabst, 2020, IgA and the intestinal microbiota: the importance of being specific, Mucosal Immunol, 13, 12, 10.1038/s41385-019-0227-4 Lindner, 2012, Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine, J Exp Med, 209, 365, 10.1084/jem.20111980 Lindner, 2015, Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota, Nat Immunol, 16, 880, 10.1038/ni.3213 Barone, 2011, IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans, Gastroenterology, 140, 947, 10.1053/j.gastro.2010.12.005 Weller, 2001, CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans, Proc Natl Acad Sci U S A, 98, 1166, 10.1073/pnas.98.3.1166 Scheeren, 2008, T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells, J Exp Med, 205, 2033, 10.1084/jem.20070447 Bunker, 2017, Natural polyreactive IgA antibodies coat the intestinal microbiota, Science, 358, 10.1126/science.aan6619 Rollenske, 2018, Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen, Nat Immunol, 19, 617, 10.1038/s41590-018-0106-2 Beura, 2016, Normalizing the environment recapitulates adult human immune traits in laboratory mice, Nature, 532, 512, 10.1038/nature17655