Immunogenicity of a Virus-Like-Particle Vaccine Containing Multiple Antigenic Epitopes of Toxoplasma gondii Against Acute and Chronic Toxoplasmosis in Mice

Jingjing Guo1, Aihua Zhou2, Xiahui Sun1, Wenchao Sha1, Kang Ai1, Pan Ge1, Chun-Xue Zhou1, Huaiyu Zhou1, Hua Cong1, Shenyi He1
1Department of Parasitology, School of Basic Medical Sciences, Shandong University, Jinan, China
2Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, School of Medicine, Shandong University, Jinan, China

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Frickel, 2008, Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes, J Infect Dis., 198, 1625, 10.1086/593019

El, 2014, Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice, Vaccine, 32, 3243, 10.1016/j.vaccine.2014.03.092

Innes, 2010, Vaccination against Toxoplasma gondii: an increasing priority for collaborative research, Expert Rev Vaccines, 9, 1117, 10.1586/erv.10.113

Smith, 2013, Applications of nanotechnology for immunology, Nat Rev Immunol., 13, 592, 10.1038/nri3488

Smith, 2015, Nanoparticles as synthetic vaccines, Curr Opin Biotechnol., 34, 217, 10.1016/j.copbio.2015.03.014

Rodríguez-Limas, 2013, Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development, Curr Opin Biotechnol., 24, 1089, 10.1016/j.copbio.2013.02.008

Kushnir, 2012, Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development, Vaccine, 31, 58, 10.1016/j.vaccine.2012.10.083

Bellier, 2013, Virus-like particle-based vaccines against hepatitis C virus infection, Expert Rev Vaccines, 12, 143, 10.1586/erv.13.10

Geldmacher, 2004, An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly cross-reactive antibody response in mice, Virology, 323, 108, 10.1016/j.virol.2004.02.022

Roose, 2013, Hepatitis B core-based virus-like particles to present heterologous epitopes, Expert Rev Vaccines, 12, 183, 10.1586/erv.12.150

Tan, 2010, Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans, Vaccine, 28, 3977, 10.1016/j.vaccine.2010.03.028

Brown, 1995, Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis, Immunology, 85, 419

Henriquez, 2010, Immunogenetics of Toxoplasma gondii informs vaccine design, Trends Parasitol., 26, 550, 10.1016/j.pt.2010.06.004

Blanchard, 2008, Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum, Nat Immunol., 9, 937, 10.1038/ni.1629

Velge-Roussel, 2001, Anti-SAG1 peptide antibodies inhibit the penetration of Toxoplasma gondii tachyzoites into enterocyte cell lines, Parasitology, 123, 225, 10.1017/S0031182001008460

Godard, 1994, Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis, Mol Immunol., 31, 1353, 10.1016/0161-5890(94)90054-X

Graille, 2005, Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response, J Mol Biol, 354, 447, 10.1016/j.jmb.2005.09.028

Siachoque, 2006, Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model, Exp Parasitol., 114, 62, 10.1016/j.exppara.2006.02.005

Cardona, 2009, Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis, Exp. Parasitol., 123, 199, 10.1016/j.exppara.2009.06.017

Grover, 2012, The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden, Infect Immun., 80, 3279, 10.1128/IAI.00425-12

Howe, 1995, Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease, J Infect Dis., 172, 1561, 10.1093/infdis/172.6.1561

Melo, 2011, Toxoplasma gondii effectors are master regulators of the inflammatory response, Trends Parasitol., 27, 487, 10.1016/j.pt.2011.08.001

Shen, 2014, Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion, Proc Natl Acad Sci U S A., 111, 3567, 10.1073/pnas.1315156111

Zhou, 2016, Metabolomic profiling of mice serum during toxoplasmosis progression using liquid chromatography-mass spectrometry, Sci Rep, 6, 19557, 10.1038/srep19557

Sockolosky, 2013, Periplasmic production via the pET expression system of soluble, bioactive human growth hormone, Protein Expr Purif., 87, 129, 10.1016/j.pep.2012.11.002

Lin, 2012, CεmX peptide-carrying HBcAg virus-like particles induced antibodies that down-regulate mIgE-B lymphocytes, Mol Immunol., 52, 190, 10.1016/j.molimm.2012.05.015

Bin, 2017, Yield optimisation of Hepatitis B virus core particles in E. coli expression system for drug delivery applications, Sci Rep, 7, 43160, 10.1038/srep43160

Qian, 2017, Immune complex negatively regulates toll-like receptor 3-triggered tumour necrosis factor α production in B cells, Cent Eur J Immunol, 42, 223, 10.5114/ceji.2017.70962

Newman, 2003, Stability and morphology comparisons of self-assembled virus-like particles from wild-type and mutant human hepatitis B virus capsid proteins, J Virol., 77, 12950, 10.1128/JVI.77.24.12950-12960.2003

Skrastina, 2008, High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers, Vaccine, 26, 1972, 10.1016/j.vaccine.2008.02.030

Dimier-Poisson, 2015, Porous nanoparticles as delivery system of complex antigens for an effective vaccine against acute and chronic Toxoplasma gondii infection, Biomaterials, 50, 164, 10.1016/j.biomaterials.2015.01.056

Guo, 2018, Chitosan microsphere used as an effective system to deliver a linked antigenic peptides vaccine protect mice against acute and chronic toxoplasmosis, Front Cell Infect Microbiol, 8, 163, 10.3389/fcimb.2018.00163

Cui, 2012, Toxoplasma gondii immune mapped protein-1 (TgIMP1) is a novel vaccine candidate against toxoplasmosis, Vaccine, 30, 2282, 10.1016/j.vaccine.2012.01.073

Zheng, 2013, The virulence-related rhoptry protein 5 (ROP5) of Toxoplasma gondii is a novel vaccine candidate against toxoplasmosis in mice, Vaccine, 31, 4578, 10.1016/j.vaccine.2013.07.058

Zlotnick, 1996, Dimorphism of hepatitis B virus capsids is strongly influenced by the C-terminus of the capsid protein, Biochemistry, 35, 7412, 10.1021/bi9604800

Seeger, 2000, Hepatitis B virus biology, Microbiol Mol Biol Rev., 64, 51, 10.1128/mmbr.64.1.51-68.2000

Whitacre, 2009, Use of hepadnavirus core proteins as vaccine platforms, Expert Rev Vaccines, 8, 1565, 10.1586/erv.09.121

Dryden, 2006, Native hepatitis B virions and capsids visualized by electron cryomicroscopy, Mol Cell, 22, 843, 10.1016/j.molcel.2006.04.025

Ravin, 2015, Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant loop region of hepatitis B core antigen: Insertion of multiple copies of M2e increases immunogenicity and protective efficiency, Vaccine, 33, 3392, 10.1016/j.vaccine.2015.04.066

Peyret, 2015, Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins, PLoS ONE, 10, e0120751, 10.1371/journal.pone.0120751

Yin, 2014, Deletion modification enhances anthrax specific immunity and protective efficacy of a hepatitis B core particle-based anthrax epitope vaccine, Immunobiology, 219, 97, 10.1016/j.imbio.2013.08.008

Skwarczynski, 2016, Peptide-based synthetic vaccines, Chem Sci, 7, 842, 10.1039/c5sc03892h

Correa, 2007, Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host, Parasite Immunol., 29, 651, 10.1111/j.1365-3024.2007.00982.x

Sayles, 2000, B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii, Infect Immun., 68, 1026, 10.1128/IAI.68.3.1026-1033.2000

Zheng, 2017, Immuno-Efficacy of a T. gondii secreted protein with an altered thrombospondin repeat (TgSPATR) As a Novel DNA Vaccine Candidate against Acute Toxoplasmosis in BALB/c Mice, Front Microbiol, 8, 216, 10.3389/fmicb.2017.00216

Zhang, 2014, Prediction of conformational B-cell epitopes, Methods Mol Biol., 1184, 185, 10.1007/978-1-4939-1115-8

Denkers, 1998, Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection, Clin Microbiol Rev., 11, 569, 10.1128/CMR.11.4.569

Filisetti, 2004, Immune response to Toxoplasma gondii, Ann Ist Super Sanita, 40, 71, 10.1093/intimm/dxy004

Ching, 2016, Evaluation of immunoprotection conferred by the subunit vaccines of GRA2 and GRA5 against acute toxoplasmosis in BALB/c Mice, Front Microbiol, 7, 609, 10.3389/fmicb.2016.00609

Sonaimuthu, 2016, Induction of protective immunity against toxoplasmosis in BALB/c mice vaccinated with Toxoplasma gondii Rhoptry-1, Front Microbiol, 7, 808, 10.3389/fmicb.2016.00808

Lecordier, 1995, Characterization of a dense granule antigen of Toxoplasma gondii (GRA6) associated to the network of the parasitophorous vacuole, Mol Biochem Parasitol., 70, 85, 10.1016/0166-6851(95)00010-X

Hajj, 2006, Characterization, biosynthesis and fate of ROP7, a ROP2 related rhoptry protein of Toxoplasma gondii, Mol Biochem Parasitol., 146, 98, 10.1016/j.molbiopara.2005.10.011

Soête, 1994, Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro, Exp Parasitol., 78, 361, 10.1006/expr.1994.1039

Luo, 2017, Induction of Protective Immunity against Toxoplasma gondii in mice by nucleoside triphosphate hydrolase-II (NTPase-II) Self-amplifying RNA vaccine encapsulated in lipid nanoparticle (LNP), Front Microbiol, 8, 605, 10.3389/fmicb.2017.00605

Gazzinelli, 1996, In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha, J Immunol., 157, 798, 10.4049/jimmunol.157.2.798

Desolme, 2000, Induction of protective immunity against toxoplasmosis in mice by DNA immunization with a plasmid encoding Toxoplasma gondii GRA4 gene, Vaccine, 18, 2512, 10.1016/s0264-410x(00)00035-9

Chen, 2014, Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice, BMC Infect Dis., 14, 487, 10.1186/1471-2334-14-487

Wang, 2017, Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice, Front Immunol, 8, 730, 10.3389/fimmu.2017.00730

Wang, 2017, Major immunodominant region of Hepatitis B virus core antigen as a delivery vector to improve the immunogenicity of the fusion antigen ROP2-SAG1 multiepitope from Toxoplasma gondii in Mice, Viral Immunol., 30, 508, 10.1089/vim.2016.0135