Immuno-intervention for the induction of transplantation tolerance through mixed chimerism

Seminars in Immunology - Tập 23 - Trang 165-173 - 2011
David H. Sachs1, Megan Sykes2, Tatsuo Kawai3, A. Benedict Cosimi3
1Transplantation Biology Research Center, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, United States
2Columbia Center for Translational Immunology, Columbia University, New York, United States
3Transplantation Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States

Tài liệu tham khảo

Billingham, 1953, Actively acquired tolerance to foreign cells, Nature, 172, 603, 10.1038/172603a0 Ildstad, 1984, Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts, Nature, 307, 168, 10.1038/307168a0 Sachs, 1989, Mixed chimerism and transplantation tolerance, vol. VII, 1171 Sharabi, 1989, Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen, J Exp Med, 169, 493, 10.1084/jem.169.2.493 Sykes, 1988, Achieving alloengraftment without graft-versus-host disease: approaches using mixed allogeneic bone marrow transplantation, Bone Marrow Transplant, 3, 379 Weiden, 1981, Antileukemic effect of chronic graft-versus-host disease, New Engl J Med, 304, 1529, 10.1056/NEJM198106183042507 Tomita, 1994, Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen, J Immunol, 153, 1087, 10.4049/jimmunol.153.3.1087 Tomita, 1996, Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3Gy whole body irradiation, Transplantation, 61, 469, 10.1097/00007890-199602150-00027 Tomita, 1996, Mechanism by which additional monoclonal antibody injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3Gy whole body irradiation, Transplantation, 61, 477, 10.1097/00007890-199602150-00028 Khan, 1996, Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance, Transplantation, 62, 380, 10.1097/00007890-199608150-00014 Manilay, 1998, Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen, Transplantation, 66, 96, 10.1097/00007890-199807150-00015 Cobbold, 1990, Reprogramming the immune system for tolerance with monoclonal antibodies, Semin Immunol, 2, 377 Nikolic, 2001, Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance, Biol Blood Marrow Transplant, 7, 144, 10.1053/bbmt.2001.v7.pm11302548 Wekerle, 1998, Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance, J Exp Med, 187, 2037, 10.1084/jem.187.12.2037 Haynes, 2000, The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection, Ann Rev Immunol, 18, 529, 10.1146/annurev.immunol.18.1.529 Wekerle, 2000, Allogeneic bone marrow transplantation with costimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment, Nat Med, 6, 464, 10.1038/74731 Ito, 2001, CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40L interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway, J Immunol, 166, 2970, 10.4049/jimmunol.166.5.2970 Kurtz, 2004, Mechanisms of early peripheral CD4 T cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion, but not regulatory cells, Blood, 103, 4336, 10.1182/blood-2003-08-2642 Fehr, 2005, Early regulation of CD8 T cell alloreactivity by CD4+CD25− T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation, Eur J Immunol, 35, 2679, 10.1002/eji.200526190 Fehr, 2008, Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells and MHC class II, J Immunol, 181, 165, 10.4049/jimmunol.181.1.165 Haspot, 2008, Peripheral deletional tolerance of alloreactive CD8 but not CD4 cells is dependent on the PD-1/PD-L1 pathway, Blood, 112, 2149, 10.1182/blood-2007-12-127449 Kurtz, 2001, Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells, Am J Transplant, 1, 339, 10.1034/j.1600-6143.2001.10409.x Wekerle, 1999, Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade, Transplant Proc, 31, 680, 10.1016/S0041-1345(98)01605-4 Bigenzahn, 2005, The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade, Am J Transplant, 5, 1237, 10.1111/j.1600-6143.2005.00862.x Domenig, 2005, Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol, J Immunol, 175, 51, 10.4049/jimmunol.175.1.51 Mapara, 2003, DLI-mediated GVL effects in mixed chimeras established with a non-myeloablative conditioning regimen: extinction of GVL effects coincides with loss of alloreactive cells following conversion to full donor chimerism, Transplantation, 76, 297, 10.1097/01.TP.0000072014.83469.2D Mapara, 2002, Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells, Blood, 100, 1903, 10.1182/blood-2002-01-0023 Boyd, 1991, Towards an integrated view of thymopoiesis, Immunol Today, 12, 71, 10.1016/0167-5699(91)90161-L Chakraverty, 2006, Host MHC Class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions, Blood, 108, 2106, 10.1182/blood-2006-03-007427 Spitzer, 2000, The intentional induction of mixed chimerism and achievement of anti-tumor responses following non-myeloablative conditioning therapy and HLA-matched and mismatched donor bone marrow transplantation for refractory hematologic malignancies, Biol Blood Marrow Transplant, 6, 309, 10.1016/S1083-8791(00)70056-5 Dey, 2003, Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-vs-host disease and anti-tumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation, Biol Blood Marrow Transplant, 9, 320, 10.1016/S1083-8791(03)00077-6 Fudaba, 2006, Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses, Am J Transplant, 6, 2121, 10.1111/j.1600-6143.2006.01434.x Spitzer, 2003, Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies, Transplantation, 75, 1748, 10.1097/01.TP.0000064211.23536.AD Kawai, 2008, HLA-mismatched renal transplantation without maintenance immunosuppression, N Engl J Med, 358, 353, 10.1056/NEJMoa071074 Gress, 1987, Biparental bone marrow transplantation as a means of tolerance induction, Transplant Proc, 19, 95 Pennington, 1988, Bone marrow transplantation in miniature swine. I. Development of the model, Transplantation, 45, 21, 10.1097/00007890-198801000-00006 Pennington, 1986, Bone marrow transplantation in miniature swine. I. Autologous and SLA matched allografts, 377 Popitz-Bergez, 1988, Bone marrow transplantation in miniature swine. II. Effect of selective genetic differences on marrow engraftment and recipient survival, Transplantation, 45, 27, 10.1097/00007890-198801000-00007 Sakamoto, 1988, Bone marrow transplantation in miniature swine. III. Graft-versus-host disease and the effect of T cell depletion of marrow, Transplantation, 45, 869, 10.1097/00007890-198805000-00006 Huang, 2000, Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model, J Clin Invest, 105, 173, 10.1172/JCI7913 Lima, 2003, Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine, Biol Blood Marrow Transplant, 9, 571, 10.1016/S1083-8791(03)00227-1 Colby, 2000, Cytokine-mobilized peripheral blood progenitor cells for allogeneic reconstitution of miniature swine, Transplantation, 69, 135, 10.1097/00007890-200001150-00023 Fuchimoto, 2000, Mixed chimerism and tolerance without whole body irradiation in a large animal model, J Clin Invest, 105, 1779, 10.1172/JCI8721 Gleit, 2002, Variable relationship between chimerism and tolerance after hematopoietic cell transplantation without myelosuppressive conditioning, Transplantation, 74, 1535, 10.1097/00007890-200212150-00010 Schwarze, 2000, Mixed hematopoietic chimerism induces long term tolerance to cardiac allografts in miniature swine, Ann Thorac Surg, 70, 131, 10.1016/S0003-4975(00)01564-2 Horner, 2006, Predictors of organ allograft tolerance following hematopoietic cell transplantation, Am J Transplant, 6, 2894, 10.1111/j.1600-6143.2006.01563.x Wu, 2004, Homeostatic proliferation is a barrier to transplantation tolerance, Nat Med, 10, 87, 10.1038/nm965 Kawai, 1995, Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys, Transplantation, 59, 256, 10.1097/00007890-199501000-00018 Kawai, 1999, Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance, Transplantation, 68, 1767, 10.1097/00007890-199912150-00022 Kawai, 2000, Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand [letter], Nat Med, 6, 114, 10.1038/72162 Koyama, 2004, Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates, Transplantation, 77, 460, 10.1097/01.TP.0000110291.29370.C0 Pitcher, 2002, Development and homeostasis of T cell memory in rhesus macaque, J Immunol, 168, 29, 10.4049/jimmunol.168.1.29 Nadazdin, 2010, Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys, Am J Transplant, 10, 1375, 10.1111/j.1600-6143.2010.03119.x Koyama, 2007, Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft, Am J Transplant, 7, 1055, 10.1111/j.1600-6143.2006.01703.x Kawai, 2001, Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor, Transplantation, 72, 351, 10.1097/00007890-200107270-00036 Sayegh, 1991, Immunologic tolerance to renal allografts after bone marrow transplants from the same donors, Ann Intern Med, 114, 954, 10.7326/0003-4819-114-11-954 Helg, 1994, Renal transplantation without immunosuppression in a host with tolerance induced by allogeneic bone marrow transplantation, Transplantation, 58, 1420 Jacobsen, 1994, Tolerance to an HLA-B,DR disparate kidney allograft after bone-marrow transplantation from same donor, Lancet, 343, 800, 10.1016/S0140-6736(94)91881-3 Dey, 1998, Outcomes of recipients of both bone marrow and solid organ transplants. A review, Medicine (Baltimore), 77, 355, 10.1097/00005792-199809000-00005 Dey, 2001, Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation, Biol Blood Marrow Transplant, 7, 604, 10.1053/bbmt.2001.v7.pm11760148 Spitzer, 1999, Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism, Transplantation, 68, 480, 10.1097/00007890-199908270-00006 Buhler, 2002, Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease, Transplantation, 74, 1405, 10.1097/00007890-200211270-00011 Newell, 2006, Toward transplantation tolerance: a large step on a long road, Am J Transplant, 6, 1989, 10.1111/j.1600-6143.2006.01481.x Sykes, 1999, Mixed lymphohematopoietic chimerism and graft-vs-lymphoma effects are achievable in adult humans following non-myeloablative therapy and HLA-mismatched donor bone marrow transplantation, Lancet, 353, 1755, 10.1016/S0140-6736(98)11135-2 Spitzer, 2001, Mixed lymphohematopoietic chimerism and delayed donor leukocyte infusions following non-myeloablative conditioning and HLA-matched and mismatched donor bone marrow transplantation, 321 Cahill, 1996, Marrow engraftment and clinical manifestations of capillary leak syndrome, Bone Marrow Transplant, 18, 177 Spitzer, 2001, Engraftment syndrome following hematopoietic stem cell transplantation, Bone Marrow Transplant, 27, 893, 10.1038/sj.bmt.1703015 Shaffer, 2007, Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine, Exp Hematol, 35, 1140, 10.1016/j.exphem.2007.03.018 Cobbold, 2004, Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants, J Immunol, 172, 6003, 10.4049/jimmunol.172.10.6003 Fehervari, 2004, Development and function of CD25+CD4+ regulatory T cells, Curr Opin Immunol, 16, 203, 10.1016/j.coi.2004.01.004 Graca, 2002, Identification of regulatory T cells in tolerated allografts, J Exp Med, 195, 1641, 10.1084/jem.20012097 Kurtz, 2004, Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells, Blood, 103, 4336, 10.1182/blood-2003-08-2642 Baron, 2001, Persistence of dominant T cell clones in accepted solid organ transplants, J Immunol, 167, 4154, 10.4049/jimmunol.167.8.4154 Griesemer, 2008, Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model, J Immunol, 181, 4027, 10.4049/jimmunol.181.6.4027 Ierino, 1997, Preliminary in vitro evidence for regulatory cells in a miniature swine renal allograft model, Transplant Proc, 29, 1165, 10.1016/S0041-1345(96)00515-5 Mezrich, 2003, The role of regulatory cells in miniature swine rendered tolerant to cardiac allografts by donor kidney cotransplantation, Am J Transplant, 3, 1107, 10.1046/j.1600-6143.2003.00202.x Wu, 2003, Regulatory mechanism of peripheral tolerance: in vitro evidence for dominant suppression of host responses during the maintenance phase of tolerance to renal allografts in miniature swine, Transplant Immunol, 11, 367, 10.1016/S0966-3274(03)00006-6 Adams, 2003, Heterologous immunity provides a potent barrier to transplantation tolerance, J Clin Invest, 111, 1887, 10.1172/JCI200317477 Sachs, 2003, Tolerance: of mice and men, J Clin Invest, 111, 1819, 10.1172/JCI18926