Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance
Tài liệu tham khảo
Broxmeyer, 2003, High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years, Proc Natl Acad Sci U S A, 100, 645, 10.1073/pnas.0237086100
Komanduri, 2007, Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing, Blood, 110, 4543, 10.1182/blood-2007-05-092130
Szabolcs, 2010, Unrelated umbilical cord blood transplantation and immune reconstitution, Semin Hematol, 47, 22, 10.1053/j.seminhematol.2009.10.009
Szabolcs, 2007, Immune reconstitution after unrelated cord blood transplantation, Cytotherapy, 9, 111, 10.1080/14653240701231014
Parody, 2006, Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation, Biol Blood Marrow Transplant, 12, 734, 10.1016/j.bbmt.2006.03.007
Szabolcs, 2008, Immune reconstitution in children after unrelated cord blood transplantation, Biol Blood Marrow Transplant, 14, 66, 10.1016/j.bbmt.2007.10.016
Macmillan, 2009, Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors, Blood, 113, 2410, 10.1182/blood-2008-07-163238
Gluckman, 1990, Transplantation of umbilical cord blood in Fanconi's anemia, Nouv Rev Fr Hematol, 32, 423
Gluckman, 1989, Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling, N Engl J Med, 321, 1174, 10.1056/NEJM198910263211707
Broxmeyer, 1989, Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells, Proc Natl Acad Sci U S A, 86, 3828, 10.1073/pnas.86.10.3828
Broxmeyer, 2009, Cord blood hematopoietic cell transplantation
Matsuno, 2009, Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation, Blood, 114, 1689, 10.1182/blood-2008-12-194696
Barker, 2001, Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis, Blood, 97, 2957, 10.1182/blood.V97.10.2957
Rocha, 2000, Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling, N Engl J Med, 342, 1846, 10.1056/NEJM200006223422501
Rocha, 2004, Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia, N Engl J Med, 351, 2276, 10.1056/NEJMoa041469
Leung, 2009, Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies, Br Med Bull, ldp040
Canto, 2003, Distinctive response of naive lymphocytes from cord blood to primary activation via TCR, J Leukoc Biol, 74, 998, 10.1189/jlb.0303098
Chen, 2006, Impaired allogeneic activation and T-helper 1 differentiation of human cord blood naive CD4 T cells, Biol Blood Marrow Transplant, 12, 160, 10.1016/j.bbmt.2005.10.027
Risdon, 1994, Allogeneic responses of human umbilical cord blood, Blood Cells, 20, 566
Risdon, 1994, Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation, Cell Immunol, 154, 14, 10.1006/cimm.1994.1053
Trenado, 2003, Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia, J Clin Invest, 112, 1688, 10.1172/JCI17702
Reen, 1998, Activation and functional capacity of human neonatal CD4 T-cells, Vaccine, 16, 1401, 10.1016/S0264-410X(98)00099-1
Yi, 2009, Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease, Blood, 114, 3101, 10.1182/blood-2009-05-219402
Yi, 2008, Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease, Blood, 112, 2101, 10.1182/blood-2007-12-126987
Fowler, 1994, Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice, Blood, 84, 3540, 10.1182/blood.V84.10.3540.3540
Krenger, 1996, Graft-versus-host disease and the Th1/Th2 paradigm, Immunol Res, 15, 50, 10.1007/BF02918284
Nitsche, 2007, Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors, BMC Immunol, 8, 18, 10.1186/1471-2172-8-18
Szabo, 2003, Molecular mechanisms regulating Th1 immune responses, Annu Rev Immunol, 21, 713, 10.1146/annurev.immunol.21.120601.140942
Kaminski, 2003, Reduced expression of NFAT-associated genes in UCB versus adult CD4+ T lymphocytes during primary stimulation, Blood, 102, 4608, 10.1182/blood-2003-05-1732
Yang, 1998, Donor-derived interferon γ is required for inhibition of acute graft-versus-host disease by interleukin 12, J Clin Invest, 102, 2126, 10.1172/JCI4992
Murphy, 1998, Differential effects of the absence of interferon-γ and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice, J Clin Invest, 102, 1742, 10.1172/JCI3906
Burman, 2007, IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract, Blood, 110, 1064, 10.1182/blood-2006-12-063982
Keir, 2008, PD-1 and its ligands in tolerance and immunity, Annu Rev Immunol, 26, 677, 10.1146/annurev.immunol.26.021607.090331
Kappel, 2009, IL-17 contributes to CD4-mediated graft-versus-host disease, Blood, 113, 945, 10.1182/blood-2008-08-172155
Carlson, 2009, In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations, Blood, 113, 1365, 10.1182/blood-2008-06-162420
Blazar, 1998, Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease 1, Transplantation, 66, 1220, 10.1097/00007890-199811150-00018
Groux, 1997, A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature, 389, 737, 10.1038/39614
Rainsford, 2002, Interleukin 10, produced in abundance by human newborn T cells, may be the regulator of increased tolerance associated with cord blood stem cell transplantation, Br J Haematol, 116, 702, 10.1046/j.0007-1048.2001.03321.x
Chakraverty, 2007, The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia, Blood, 110, 9, 10.1182/blood-2006-12-022038
Chunduri, 2008, Cord blood nucleated cells induce delayed T cell alloreactivity, Biol Blood Marrow Transplant, 14, 872, 10.1016/j.bbmt.2008.05.009
Sorg, 1999, Identification of cord blood dendritic cells as an immature CD11c− population, Blood, 93, 2302, 10.1182/blood.V93.7.2302
Borràs, 2001, Identification of both myeloid CD11c+ and lymphoid CD11c− dendritic cell subsets in cord blood, Br J Haematol, 113, 925, 10.1046/j.1365-2141.2001.02840.x
Kollmann, 2009, Neonatal innate TLR-mediated responses are distinct from those of adults, J Immunol, 183, 7150, 10.4049/jimmunol.0901481
Sandeep, 2008, Cord blood nucleated cells induce delayed T cell alloreactivity. biology of blood and marrow transplantation, J Am Soc Blood Marrow Transplant, 14, 872, 10.1016/j.bbmt.2008.05.009
Liu, 2001, Decreased yield, phenotypic expression and function of immature monocyte-derived dendritic cells in cord blood, Br J Haematol, 113, 240, 10.1046/j.1365-2141.2001.02720.x
Rescigno, 1998, Dendritic cell survival and maturation are regulated by different signaling pathways, J Exp Med, 188, 2175, 10.1084/jem.188.11.2175
Banchereau, 2000, Immunobiology of dendritic cells, Annu Rev Immunol, 18, 767, 10.1146/annurev.immunol.18.1.767
Martin-Fontecha, 2008, CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming, J Exp Med, 205, 2561, 10.1084/jem.20081212
Drohan, 2004, Selective developmental defects of cord blood antigen-presenting cell subsets, Human Immunol, 65, 1356, 10.1016/j.humimm.2004.09.011
Goriely, 2001, Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes, J Immunol, 166, 2141, 10.4049/jimmunol.166.3.2141
Langrish, 2002, Neonatal dendritic cells are intrinsically biased against Th-1 immune responses, Clin Exp Immunol, 128, 118, 10.1046/j.1365-2249.2002.01817.x
Naderi, 2009, Cord blood dendritic cells prevent the differentiation of naive T-helper cells towards Th1 irrespective of their subtype, Clin Exp Med, 9, 29, 10.1007/s10238-008-0020-2
Arpinati, 2003, Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation, Transplant Immunol, 11, 345, 10.1016/S0966-3274(03)00055-8
Crespo, 2004, Immunophenotypic and functional characterization of cord blood dendritic cells, Stem Cells Dev, 13, 63, 10.1089/154732804773099263
Mahnke, 2002, Immature, but not inactive: the tolerogenic function of immature dendritic cells, Immunol Cell Biol, 80, 477, 10.1046/j.1440-1711.2002.01115.x
Steinbrink, 2009, Myeloid dendritic cell: from sentinel of immunity to key player of peripheral tolerance?, Human Immunol, 70, 289, 10.1016/j.humimm.2009.02.003
Toubai, 2010, Immunization with host-type CD8α+ dendritic cells reduces experimental acute GVHD in an IL-10-dependent manner, Blood, 115, 724, 10.1182/blood-2009-06-229708
Kubach, 2005, Dendritic cells: sentinels of immunity and tolerance, Int J Hematol, 81, 197, 10.1532/IJH97.04165
Rutella, 2006, Tolerogenic dendritic cells: cytokine modulation comes of age, Blood, 108, 1435, 10.1182/blood-2006-03-006403
Chidgey, 2008, Tolerance strategies for stem-cell-based therapies, Nature, 453, 330, 10.1038/nature07041
Roncarolo, 2001, Differentiation of T regulatory cells by immature dendritic cells, J Exp Med, 193, F5, 10.1084/jem.193.2.F5
Jonuleit, 2000, Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells, J Exp Med, 192, 1213, 10.1084/jem.192.9.1213
Yamazaki, 2006, Dendritic cells expand antigen-specific Foxp3+CD25+CD4+ regulatory T cells including suppressors of alloreactivity, Immunol Rev, 212, 314, 10.1111/j.0105-2896.2006.00422.x
Dhodapkar, 2001, Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells, J Exp Med, 193, 233, 10.1084/jem.193.2.233
Jiang, 2005, Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells, Blood, 105, 4120, 10.1182/blood-2004-02-0586
Saito, 1992, High serum human macrophage colony-stimulating factor level during pregnancy, Int J Hematol, 55, 219
Mellor, 2000, Immunology at the maternal–fetal interface: lessons for T cell tolerance and suppression, Annu Rev Immunol, 18, 367, 10.1146/annurev.immunol.18.1.367
Li, 2005, Macrophage colony-stimulating factor drives cord blood monocyte differentiation into IL-10highIL-12absent dendritic cells with tolerogenic potential, J Immunol, 174, 4706, 10.4049/jimmunol.174.8.4706
Tolar, 2009, Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells, Br J Haematol, 147, 200, 10.1111/j.1365-2141.2009.07781.x
Sakaguchi, 1995, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J Immunol, 155, 1151, 10.4049/jimmunol.155.3.1151
Sakaguchi, 2004, Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses, Annu Rev Immunol, 22, 531, 10.1146/annurev.immunol.21.120601.141122
Fontenot, 2005, Regulatory T cell lineage specification by the forkhead transcription factor foxp3, Immunity, 22, 329, 10.1016/j.immuni.2005.01.016
Dieckmann, 2001, Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood, J Exp Med, 193, 1303, 10.1084/jem.193.11.1303
Shimizu, 2002, Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance, Nat Immunol, 3, 135, 10.1038/ni759
Mchugh, 2002, CD4+CD25+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor, Immunity, 16, 311, 10.1016/S1074-7613(02)00280-7
Valzasina, 2005, Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR, Blood, 105, 2845, 10.1182/blood-2004-07-2959
Taylor, 2004, L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection, Blood, 104, 3804, 10.1182/blood-2004-05-1850
Ermann, 2005, Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD, Blood, 105, 2220, 10.1182/blood-2004-05-2044
Wei, 2006, Regulatory T-cell compartmentalization and trafficking, Blood, 108, 426, 10.1182/blood-2006-01-0177
Iellem, 2001, Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T Cells, J Exp Med, 194, 847, 10.1084/jem.194.6.847
Nakamura, 2004, TGF-β 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice, J Immunol, 172, 834, 10.4049/jimmunol.172.2.834
Oida, 2006, TGF-β-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling, J Immunol, 177, 2331, 10.4049/jimmunol.177.4.2331
Zheng, 2007, IL-2 is essential for TGF-β to convert naive CD4+CD25− cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells, J Immunol, 178, 2018, 10.4049/jimmunol.178.4.2018
Bettelli, 2006, Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, 441, 235, 10.1038/nature04753
Korn, 2007, IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells, Nature, 448, 484, 10.1038/nature05970
Gao, 2007, Contrasting Effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells, Am J Transplant, 7, 1722, 10.1111/j.1600-6143.2007.01842.x
Sauer, 2008, T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR, Proc Natl Acad Sci U S A, 105, 7797, 10.1073/pnas.0800928105
Raimondi, 2010, Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients, J Immunol, 184, 624, 10.4049/jimmunol.0900936
Asano, 1996, Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation, J Exp Med, 184, 387, 10.1084/jem.184.2.387
Suri-Payer, 1998, CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells, J Immunol, 160, 1212, 10.4049/jimmunol.160.3.1212
Thornton, 1998, CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production, J Exp Med, 188, 287, 10.1084/jem.188.2.287
Thornton, 2000, Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific, J Immunol, 164, 183, 10.4049/jimmunol.164.1.183
Waldmann, 1991, The interleukin-2 receptor, J Biol Chem, 266, 2681, 10.1016/S0021-9258(18)49895-X
Zola, 1995, Expression of cytokine receptors by human cord blood lymphocytes: comparison with adult blood lymphocytes, Pediatr Res, 38, 397, 10.1203/00006450-199509000-00021
Taga, 1991, Preferential expression of IL-2 receptor subunits on memory populations within CD4+ and CD8+ T cells, Immunology, 72, 15
Baecher-Allan, 2001, CD4+CD25high regulatory cells in human peripheral blood, J Immunol, 167, 1245, 10.4049/jimmunol.167.3.1245
Wing, 2002, Characterization of human CD25+CD4+ T cells in thymus,cord and adult blood, Immunology, 106, 190, 10.1046/j.1365-2567.2002.01412.x
Fontenot, 2003, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat Immunol, 4, 330, 10.1038/ni904
Roncador, 2005, Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level, Eur J Immunol, 35, 1681, 10.1002/eji.200526189
Seddiki, 2006, Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells, J Exp Med, 203, 1693, 10.1084/jem.20060468
Hoffmann, 2006, Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion, Blood, 108, 4260, 10.1182/blood-2006-06-027409
Booth, 2010, Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO, J Immunol, 184, 4317, 10.4049/jimmunol.0903781
Godfrey, 2005, Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function, Blood, 105, 750, 10.1182/blood-2004-06-2467
Coenen, 2006, Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells, Blood, 107, 1018, 10.1182/blood-2005-07-3032
Ng, 2001, Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells, Blood, 98, 2736, 10.1182/blood.V98.9.2736
Lee, 2009, The regulatory function of umbilical cord blood CD4+CD25+ T cells stimulated with anti-CD3/anti-CD28 and exogenous interleukin (IL)-2 or IL-15, Pediatric Allergy and Immunology, 20, 624, 10.1111/j.1399-3038.2008.00843.x
Wing, 2003, CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells, Eur J Immunol, 33, 579, 10.1002/eji.200323701
Chang, 2005, Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naive and antigenic-specific cord blood Treg cells, Exp Hematol, 33, 1508, 10.1016/j.exphem.2005.09.002
Schaub, 2009, Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells, J Allergy Clin Immunol, 123, 774, 10.1016/j.jaci.2009.01.056
Wood, 2003, Regulatory T cells in transplantation tolerance, Nat Rev Immunol, 3, 199, 10.1038/nri1027
Anderson, 2004, Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease, Blood, 104, 1565, 10.1182/blood-2004-01-0328
Zhao, 2008, In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease, Blood, 112, 2129, 10.1182/blood-2008-02-140277
Sakaguchi, 2001, Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance, Immunol Rev, 182, 18, 10.1034/j.1600-065X.2001.1820102.x
Hanash, 2005, Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation, Blood, 105, 1828, 10.1182/blood-2004-08-3213
Cohen, 2002, CD4+CD25+ Immunoregulatory T cells: new therapeutics for graft-versus-host disease, J Exp Med, 196, 401, 10.1084/jem.20020090
Taylor, 2002, The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality, Blood, 99, 3493, 10.1182/blood.V99.10.3493
Chen, 2007, Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease, Blood, 110, 3804, 10.1182/blood-2007-05-091074
Oldenhove, 2009, Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection, Immunity, 31, 772, 10.1016/j.immuni.2009.10.001
Zeiser, 2006, Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production, Blood, 108, 390, 10.1182/blood-2006-01-0329
Hippen, 2008, Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells, Blood, 112, 2847, 10.1182/blood-2008-01-132951
Godfrey, 2004, In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures, Blood, 104, 453, 10.1182/blood-2004-01-0151
Junji, 2007, Expansion of natural killer cell receptor (CD94/NKG2A)-expressing cytolytic CD8 T cells and CD4+CD25+ regulatory T cells from the same cord blood unit, Exp Hematol, 35, 1562, 10.1016/j.exphem.2007.06.006
Bacchetta, 2002, Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines, Eur J Immunol, 32, 2237, 10.1002/1521-4141(200208)32:8<2237::AID-IMMU2237>3.0.CO;2-2
Koenen, 2003, IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression, J Immunol, 171, 6431, 10.4049/jimmunol.171.12.6431
Zeiser, 2008, Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells, Blood, 111, 453, 10.1182/blood-2007-06-094482
Hutton, 2009, Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells, J Leukoc Biol, 85, 445, 10.1189/jlb.1008620
Martin, 2008, Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells, Blood, 112, 2730, 10.1182/blood-2008-01-133801
Abdallah, 2007, Human mesenchymal stem cells: from basic biology to clinical applications, Gene Ther, 15, 109, 10.1038/sj.gt.3303067
Bianco, 2008, Mesenchymal stem cells: revisiting history, concepts, and assays, Cell Stem Cell, 2, 313, 10.1016/j.stem.2008.03.002
Kern, 2006, Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord Blood, or adipose tissue, Stem Cells, 24, 1294, 10.1634/stemcells.2005-0342
Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143
Cetrulo, 2006, Cord-blood mesenchymal stem cells and tissue engineering, Stem Cell Rev, 2, 163, 10.1007/s12015-006-0023-x
Caplan, 2009, Why are MSCs therapeutic? New data: new insight, J Pathol, 217, 318, 10.1002/path.2469
Phinney, 2007, Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair, Stem Cells, 25, 2896, 10.1634/stemcells.2007-0637
Schugar, 2009, High harvest yield, high expansion, and phenotype stability of CD146 mesenchymal stromal cells from whole primitive human umbilical cord tissue, J Biomed Biotechnol, 2009, 789526, 10.1155/2009/789526
Prockop, 2009, Repair of tissues by adult stem/progenitor cells (MSCs): Controversies, myths, and changing paradigms, Mol Ther, 17, 939, 10.1038/mt.2009.62
Wang, 2009, The immunomodulatory activity of human umbilical cord blood-derived mesenchymal stem cells in vitro, Immunology, 126, 220, 10.1111/j.1365-2567.2008.02891.x
Ren, 2008, Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide, Cell Stem Cell, 2, 141, 10.1016/j.stem.2007.11.014
Glennie, 2005, Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells, Blood, 105, 2821, 10.1182/blood-2004-09-3696
Maitra, 2004, Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation, Bone Marrow Transplant, 33, 597, 10.1038/sj.bmt.1704400
Keating, 2006, Mesenchymal stromal cells, Curr Opin Hematol, 13, 419, 10.1097/01.moh.0000245697.54887.6f
Rasmusson, 2005, Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms, Exp Cell Res, 305, 33, 10.1016/j.yexcr.2004.12.013
Augello, 2005, Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway, Eur J Immunol, 35, 1482, 10.1002/eji.200425405
Aggarwal, 2005, Human mesenchymal stem cells modulate allogeneic immune cell responses, Blood, 105, 1815, 10.1182/blood-2004-04-1559
Bartholomew, 2002, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo, Exp Hematol, 30, 42, 10.1016/S0301-472X(01)00769-X
Sato, 2007, Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells, Blood, 109, 228, 10.1182/blood-2006-02-002246
Beyth, 2005, Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness, Blood, 105, 2214, 10.1182/blood-2004-07-2921
Tisato, 2007, Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease, Leukemia, 21, 1992, 10.1038/sj.leu.2404847
Romieu-Mourez, 2007, Regulation of MHC class II expression and antigen processing in murine and human mesenchymal stromal cells by IFN-γ, TGF-β, and cell density, J Immunol, 179, 1549, 10.4049/jimmunol.179.3.1549
Batten, 2006, Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves, Tissue Eng, 12, 2263, 10.1089/ten.2006.12.2263
Groh, 2005, Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells, Exp Hematol, 33, 928, 10.1016/j.exphem.2005.05.002
Meisel, 2004, Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation, Blood, 103, 4619, 10.1182/blood-2003-11-3909
Chen, 2010, Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism, Clin Immunol, 10.1016/j.clim.2010.01.015
Djouad, 2005, Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis, Arthritis Rheum, 52, 1595, 10.1002/art.21012
Gonzalez, 2009, Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells, Arthritis Rheum, 60, 1006, 10.1002/art.24405
Erices, 2000, Mesenchymal progenitor cells in human umbilical cord blood, Br J Haematol, 109, 235, 10.1046/j.1365-2141.2000.01986.x
Lee Ok, 2004, Isolation of multipotent mesenchymal stem cells from umbilical cord blood, Blood, 103, 1669, 10.1182/blood-2003-05-1670
Goodwin, 2001, Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers, Biol Blood Marrow Transplant, 7, 581, 10.1053/bbmt.2001.v7.pm11760145
Bieback, 2004, Critical parameters for the isolation of mesenchymal stem cells from umbilical cord bood, Stem Cells, 22, 625, 10.1634/stemcells.22-4-625
Secco, 2008, Multipotent stem cells from umbilical cord: cord is richer than blood!, Stem Cells, 26, 146, 10.1634/stemcells.2007-0381
Wexler, 2003, Adult bone marrow is a rich source of human mesenchymal ‘stem’ cells but umbilical cord and mobilized adult blood are not, Br J Haematol, 121, 368, 10.1046/j.1365-2141.2003.04284.x
Mareschi, 2001, Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood, Haematologica, 86, 1099
Romanov, 2003, Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord, Stem Cells, 21, 105, 10.1634/stemcells.21-1-105
Wang, 2004, Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord, Stem Cells, 22, 1330, 10.1634/stemcells.2004-0013
Lu, 2006, Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials, Haematologica, 91, 1017
Boissel, 2008, Umbilical cord mesenchymal stem cells increase expansion of cord blood natural killer cells, Biol Blood Marrow Transplant, 14, 1031, 10.1016/j.bbmt.2008.06.016
Secco, 2009, Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood, Stem Cell Rev, 5, 387, 10.1007/s12015-009-9098-5
Crisan, 2008, A perivascular origin for mesenchymal stem cells in multiple human organs, Cell Stem Cell, 3, 301, 10.1016/j.stem.2008.07.003
Can, 2007, Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells, Stem Cells, 25, 2886, 10.1634/stemcells.2007-0417
Weiss, 2006, Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease, Stem Cells, 24, 781, 10.1634/stemcells.2005-0330
Weiss, 2006, Stem cells in the umbilical cord, Stem Cell Rev, 2, 155, 10.1007/s12015-006-0022-y
Covas, 2008, Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts, Exp Hematol, 36, 642, 10.1016/j.exphem.2007.12.015
Meirelles, 2008, In search of the in vivo identity of mesenchymal stem cells, Stem Cells, 26, 2287, 10.1634/stemcells.2007-1122
Sarugaser, 2005, Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors, Stem Cells, 23, 220, 10.1634/stemcells.2004-0166
Baksh, 2007, Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow, Stem Cells, 25, 1384, 10.1634/stemcells.2006-0709
Panepucci, 2004, Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells, Stem Cells, 22, 1263, 10.1634/stemcells.2004-0024
Friedman, 2007, Umbilical cord mesenchymal stem cells: adjuvants for human cell transplantation, Biol Blood Marrow Transplant, 13, 1477, 10.1016/j.bbmt.2007.08.048
Park, 2008, Disease-specific induced pluripotent stem cells, Cell, 134, 877, 10.1016/j.cell.2008.07.041
Broxmeyer, 2010, Will iPS cells enhance therapeutic applicability of cord blood cells and banking?, Cell Stem Cell, 6, 21, 10.1016/j.stem.2009.12.008
Feldmann, 2005, Stem cell proteomes: a profile of human mesenchymal stem cells derived from umbilical cord blood, Electrophoresis, 26, 2749, 10.1002/elps.200410406
Liu, 2005, Cytokine interactions in mesenchymal stem cells from cord blood, Cytokine, 32, 270, 10.1016/j.cyto.2005.11.003
Yoo, 2009, Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues, Cell Immunol, 259, 150, 10.1016/j.cellimm.2009.06.010
Bieback, 2007, Mesenchymal stromal cells from umbilical cord blood, Curr Stem Cell Res Ther, 2, 310, 10.2174/157488807782793763
Bieback, 2008, Comparing mesenchymal stromal cells from different human tissues: bone marrow, adipose tissue and umbilical cord blood, Biomed Mater Eng, 18, S71
Rebelatto, 2008, Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue, Exp Biol Med, 233, 901, 10.3181/0712-RM-356
Kakinuma, 2003, Human umbilical cord blood as a source of transplantable hepatic progenitor cells, Stem Cells, 21, 217, 10.1634/stemcells.21-2-217
Kögler, 2004, A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential, J Exp Med, 200, 123, 10.1084/jem.20040440
Kogler, 2006, Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood, Exp Hematol, 34, 1589, 10.1016/j.exphem.2006.07.011
Mcguckin, 2005, Production of stem cells with embryonic characteristics from human umbilical cord blood, Cell Proliferation, 38, 245, 10.1111/j.1365-2184.2005.00346.x
Kucia, 2006, Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood—preliminary report, Leukemia, 21, 297, 10.1038/sj.leu.2404470
Mueller, 2001, Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges, J Cell Biochem, 82, 583, 10.1002/jcb.1174
Stenderup, 2003, Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells, Bone, 33, 919, 10.1016/j.bone.2003.07.005
Rao, 2001, Stem cells and aging: expanding the possibilities, Mech Ageing Dev, 122, 713, 10.1016/S0047-6374(01)00224-X
Zappia, 2005, Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy, Blood, 106, 1755, 10.1182/blood-2005-04-1496
Lazarus, 2005, Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients, Biol Blood Marrow Transplant, 11, 389, 10.1016/j.bbmt.2005.02.001
Ringden, 2006, Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease, Transplantation, 81, 1390, 10.1097/01.tp.0000214462.63943.14
Sandhu, 1995, A human model of xenogeneic graft-versus-host disease in SCID mice engrafted with human peripheral blood lymphocytes, Transplantation, 60, 179, 10.1097/00007890-199507270-00011
Sudres, 2006, Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice, J Immunol, 176, 7761, 10.4049/jimmunol.176.12.7761
Nauta, 2006, Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting, Blood, 108, 2114, 10.1182/blood-2005-11-011650
Eliopoulos, 2005, Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice, Blood, 106, 4057, 10.1182/blood-2005-03-1004
Chung, 2004, Cotransplantation of marrow stromal cells may prevent lethal graft-versus-host disease in major histocompatibility complex mismatched murine hematopoietic stem cell transplantation, Int J Hematol, 80, 370, 10.1532/IJH97.A30409
Von Bonin, 2008, Treatment of refractory acute GVHD with third-party MSC expanded in platelet lysate-containing medium, Bone Marrow Transplant, 43, 245, 10.1038/bmt.2008.316
Zhou, 2010, Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report, Biol Blood Marrow Transplant, 16, 403, 10.1016/j.bbmt.2009.11.006
Gonzalo-Daganzo, 2009, Results of a pilot study on the use of third-party donor mesenchymal stromal cells in cord blood transplantation in adults, Cytotherapy, 11, 278, 10.1080/14653240902807018
Le Blanc, 2006, Mesenchymal stem cells: properties and role in clinical bone marrow transplantation, Curr Opin Immunol, 18, 586, 10.1016/j.coi.2006.07.004
Olson, 2010, NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects, Blood, 10.1182/blood-2009-05-222190
Xu, 2005, Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis, J Neuroimmunol, 163, 24, 10.1016/j.jneuroim.2005.02.011
Rabinovich, 2003, Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells, J Immunol, 170, 3572, 10.4049/jimmunol.170.7.3572
Gaddy, 1997, Cord blood CD16+56− cells with low lytic activity are possible precursors of mature natural killer cells, Cell Immunol, 180, 132, 10.1006/cimm.1997.1175
Fan, 2008, Phenotypic and functional heterogeneity of natural killer cells from umbilical cord blood mononuclear cells, Immunol Invest, 37, 79, 10.1080/10826080701690714
Dalle, 2005, Characterization of cord blood natural killer cells: implications for transplantation and neonatal infections, Pediatric Res, 57, 649, 10.1203/01.PDR.0000156501.55431.20
Wang, 2007, High expression of NKG2A/CD94 and low expression of granzyme B are associated with reduced cord blood NK cell activity, Cell Mol Immunol, 4, 377
Lu, 2008, CD16+ CD56− NK cells in the peripheral blood of cord blood transplant recipients: a unique subset of NK cells possibly associated with graft-versus-leukemia effect, Eur J Haematol, 81, 18, 10.1111/j.1600-0609.2008.01073.x
Mavilio, 2005, Characterization of CD56−/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals, Proc Natl Acad Sci U S A, 102, 2886, 10.1073/pnas.0409872102
Gonzalez, 2008, Expansion of CD56− NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNα and ribavirin, Clin Immunol, 128, 46, 10.1016/j.clim.2008.03.521
Zarife, 2009, Increased frequency of CD56BrightNK−cells, CD3−CD16+CD56− NK−cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV, J Med Virol, 81, 49, 10.1002/jmv.21340
Barker, 2005, Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy, Blood, 105, 1343, 10.1182/blood-2004-07-2717
Majhail, 2006, Double umbilical cord blood transplantation, Curr Opin Immunol, 18, 571, 10.1016/j.coi.2006.07.015
Brunstein, 2007, Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease, Blood, 110, 3064, 10.1182/blood-2007-04-067215
Ballen, 2007, Double unrelated reduced-intensity umbilical cord blood transplantation in adults, Biol Blood Marrow Transplant, 13, 82, 10.1016/j.bbmt.2006.08.041
Christopherson, 2004, Modulation of hematopoietic stem cell homing and engraftment by CD26, Science, 305, 1000, 10.1126/science.1097071
Campbell, 2007, Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice, Stem Cells Dev, 16, 347, 10.1089/scd.2007.9995
Campbell, 2008, CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation, Front Biosci, 13, 1795, 10.2741/2800