Immune receptor mimicking hormone receptors: a new guarding strategy
Tóm tắt
Plant intracellular nucleotide-binding domain leucine-rich repeat (NLR) receptors play crucial roles in immune responses against pathogens. How diverse NLRs recognize different pathogen effectors remains a significant question. A recent study published in Nature uncovered how pepper NLR Tsw detects phytohormone receptors’ interference caused by tomato spotted wilt virus (TSWV) effector, triggering a robust immune response, showcasing a new manner of NLR guarding.
Tài liệu tham khảo
Berens ML, Berry HM, Mine A, Argueso CT, Tsuda K (2017) Evolution of Hormone Signaling Networks in Plant Defense. Annu Rev Phytopathol 55:401–425. https://doi.org/10.1146/annurev-phyto-080516-035544
Chen J, Zhao Y, Luo X, Hong H, Yang T, Huang S, Wang C, Chen H, Qian X, Feng M, Chen Z, Dong Y, Ma Z, Li J, Zhu M, He SY, Dinesh-Kumar SP, Tao X (2023) NLR surveillance of pathogen interference with hormone receptors induces immunity. Nature 613(7942):145–152. https://doi.org/10.1038/s41586-022-05529-9
de Ronde D, Butterbach P, Lohuis D, Hedil M, van Lent JW, Kormelink R (2013) Tsw gene-based resistance is triggered by a functional RNA silencing suppressor protein of the Tomato spotted wilt virus. Mol Plant Pathol 14(4):405–415. https://doi.org/10.1111/mpp.12016
Han X, Kahmann R (2019) Manipulation of Phytohormone Pathways by Effectors of Filamentous Plant Pathogens. Front Plant Sci 10:822. https://doi.org/10.3389/fpls.2019.00822
Jones JD, Vance RE, Dangl JL (2016) Intracellular innate immune surveillance devices in plants and animals. Science 354(6316):aaf6395. https://doi.org/10.1126/science.aaf6395
Jumper J, Evans R, Pritzel A et al (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596(7873):583–589. https://doi.org/10.1038/s41586-021-03819-2
Le Roux C, Huet G, Jauneau A et al (2015) A receptor pair with an integrated decoy converts pathogen disabling of transcription factors to immunity. Cell 161(5):1074–1088. https://doi.org/10.1016/j.cell.2015.04.025
Mackey D, Holt BF 3rd, Wiig A, Dangl JL (2002) RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell 108(6):743–754. https://doi.org/10.1016/s0092-8674(02)00661-x
Mackey D, Belkhadir Y, Alonso JM, Ecker JR, Dangl JL (2003) Arabidopsis RIN4 is a target of the type III virulence effector AvrRpt2 and modulates RPS2-mediated resistance. Cell 112(3):379–389. https://doi.org/10.1016/s0092-8674(03)00040-0
Maruta N, Burdett H, Lim BYJ et al (2022) Structural basis of NLR activation and innate immune signalling in plants. Immunogenetics 74(1):5–26. https://doi.org/10.1007/s00251-021-01242-5
Sarris PF, Duxbury Z, Huh SU et al (2015) A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors. Cell 161(5):1089–1100. https://doi.org/10.1016/j.cell.2015.04.024
Takeuchi J, Fukui K, Seto Y, Takaoka Y, Okamoto M (2021) Ligand-receptor interactions in plant hormone signaling. Plant J 105(2):290–306. https://doi.org/10.1111/tpj.15115
van Wersch S, Tian L, Hoy R, Li X (2019) Plant NLRs: The Whistleblowers of Plant Immunity. Plant Commun 1(1):100016. https://doi.org/10.1016/j.xplc.2019.100016